The Definition, Assessment, and Prevalence of (Human Assumed) Central Sensitisation in Patients with Chronic Low Back Pain: A Systematic Review

Central sensitisation is assumed to be one of the underlying mechanisms for chronic low back pain. Because central sensitisation is not directly assessable in humans, the term ‘human assumed central sensitisation’ (HACS) is suggested. The objectives were to investigate what definitions for HACS have been used, to evaluate the methods to assess HACS, to assess the validity of those methods, and to estimate the prevalence of HACS. Database search resulted in 34 included studies. Forty different definition references were used to define HACS. This review uncovered twenty quantitative methods to assess HACS, including four questionnaires and sixteen quantitative sensory testing measures. The prevalence of HACS in patients with chronic low back pain was estimated in three studies. The current systematic review highlights that multiple definitions, assessment methods, and prevalence estimates are stated in the literature regarding HACS in patients with chronic low back pain. Most of the assessment methods of HACS are not validated but have been tested for reliability and repeatability. Given the lack of a gold standard to assess HACS, an initial grading system is proposed to standardize clinical and research assessments of HACS in patients with a chronic low back.

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The Influence of Cognitive Behavioral Therapy on Pain, Quality of Life, and Depression in Patients Receiving Physical Therapy for Chronic Low Back Pain: A Systematic Review

PM&R ◽

10.1016/j.pmrj.2018.09.029 ◽

2019 ◽

Vol 11 (2) ◽

pp. 167-176 ◽

Cited By ~ 12

Author(s):

Abdolhamid Hajihasani ◽

Mitra Rouhani ◽

Mahyar Salavati ◽

Rosita Hedayati ◽

Amir H. Kahlaee

Keyword(s):

Quality Of Life ◽

Systematic Review ◽

Low Back Pain ◽

Back Pain ◽

Physical Therapy ◽

Cognitive Behavioral Therapy ◽

Chronic Low Back Pain ◽

Behavioral Therapy ◽

Low Back

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Is yoga an effective treatment in the management of patients with chronic low back pain compared with other care modalities – a systematic review

Journal of Complementary and Integrative Medicine ◽

10.1515/jcim-2012-0007 ◽

2013 ◽

Vol 10 (1) ◽

Cited By ~ 6

Author(s):

Christopher Hill

Keyword(s):

Systematic Review ◽

Low Back Pain ◽

Back Pain ◽

Effective Treatment ◽

Chronic Low Back Pain ◽

Low Back

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A systematic review of pain and disability outcomes of pain neuroscience education (PNE) in the management of chronic low back pain

The Spine Journal ◽

10.1016/j.spinee.2016.01.042 ◽

2016 ◽

Vol 16 (4) ◽

pp. S51 ◽

Cited By ~ 2

Author(s):

Lianne Wood ◽

Paul Hendrick ◽

Nasir Quraishi

Keyword(s):

Systematic Review ◽

Low Back Pain ◽

Back Pain ◽

Chronic Low Back Pain ◽

Low Back ◽

Neuroscience Education

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Psychosocial factors influence participation in people with chronic low back pain: a systematic review

Physiotherapy ◽

10.1016/j.physio.2016.10.365 ◽

2016 ◽

Vol 102 ◽

pp. e46

Author(s):

M. Alotaibi ◽

R. Das Nair ◽

K. Radford

Keyword(s):

Systematic Review ◽

Low Back Pain ◽

Back Pain ◽

Psychosocial Factors ◽

Chronic Low Back Pain ◽

Low Back

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Intervertebral disc therapies for non-specific chronic low back pain: a systematic review and meta-analysis

Therapeutic Advances in Musculoskeletal Disease ◽

10.1177/1759720x211028001 ◽

2021 ◽

Vol 13 ◽

pp. 1759720X2110280

Author(s):

Camille Daste ◽

Stéphanie Laclau ◽

Margaux Boisson ◽

François Segretin ◽

Antoine Feydy ◽

...

Keyword(s):

Systematic Review ◽

Low Back Pain ◽

Back Pain ◽

Intervertebral Disc ◽

Chronic Low Back Pain ◽

Meta Analysis ◽

Activity Limitations ◽

Low Back ◽

Short Term

Objectives: We aim to evaluate the benefits and harms of intervertebral disc therapies (IDTs) in people with non-specific chronic low back pain (NScLBP). Methods: We conducted a systematic review and meta-analysis of randomized trials of IDTs versus placebo interventions, active comparators or usual care. EMBASE, MEDLINE, CENTRAL and CINHAL databases and conference abstracts were searched from inception to June 2020. Two independent investigators extracted data. The primary outcome was LBP intensity at short term (1 week–3 months), intermediate term (3–6 months) and long term (after 6 months). Results: Of 18 eligible trials (among 1396 citations), five assessed glucocorticoids (GCs) IDTs and were included in a quantitative synthesis; 13 assessed other products including etanercept ( n = 2), tocilizumab ( n = 1), methylene blue ( n = 2), ozone ( n = 2), chymopapaine ( n = 1), glycerol ( n = 1), stem cells ( n = 1), platelet-rich plasma ( n = 1) and recombinant human growth and differentiation factor-5 ( n = 2), and were included in a narrative synthesis. Standardized mean differences (95% CI) for GC IDTs for LBP intensity and activity limitations were −1.33 (−2.34; −0.32) and −0.76 (−1.85; 0.34) at short term, −2.22 (−5.34; 0.90) and −1.60 (−3.51; 0.32) at intermediate term and −1.11 (−2.91; 0.70) and −0.63 (−1.68; 0.42) at long term, respectively. Odds ratios (95% CI) for serious and minor adverse events with GC IDTs were 1.09 (0.25; 4.65) and 0.97 (0.49; 1.91). Conclusion: GC IDTs are associated with a reduction in LBP intensity at short term in people with NScLBP. Positive effects are not sustained. IDTs have no effect on activity limitations. Our conclusions are limited by high heterogeneity and a limited methodological quality across studies. Registration PROSPERO: CRD42019106336.

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The effectiveness of manual therapy on musculoskeletal and respiratory parameters in patients with chronic low back pain: A systematic review

Critical Reviews in Physical and Rehabilitation Medicine ◽

10.1615/critrevphysrehabilmed.2021038977 ◽

2021 ◽

Author(s):

Petros Tatsios ◽

George Koumantakis ◽

Palina Karakasidou ◽

Anastasios Philippou

Keyword(s):

Systematic Review ◽

Low Back Pain ◽

Back Pain ◽

Manual Therapy ◽

Chronic Low Back Pain ◽

Low Back ◽

Respiratory Parameters

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Structural and functional brain abnormalities in chronic low back pain: A systematic review☆

Seminars in Arthritis and Rheumatism ◽

10.1016/j.semarthrit.2015.05.002 ◽

2015 ◽

Vol 45 (2) ◽

pp. 229-237 ◽

Cited By ~ 93

Author(s):

Jeroen Kregel ◽

Mira Meeus ◽

Anneleen Malfliet ◽

Mieke Dolphens ◽

Lieven Danneels ◽

...

Keyword(s):

Systematic Review ◽

Low Back Pain ◽

Back Pain ◽

Chronic Low Back Pain ◽

Low Back ◽

Brain Abnormalities ◽

Functional Brain

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EXTRACORPOREAL SHOCK WAVE THERAPY (ESWT) IN CHRONIC LOW BACK PAIN: A SYSTEMATIC REVIEW OF RANDOMIZED CLINICAL TRIALS

HIGHER SCHOOL’S PULSE ◽

10.5604/01.3001.0013.9718 ◽

2020 ◽

Vol 13 (4) ◽

pp. 1-16

Author(s):

Karolina Walewicz

Keyword(s):

Systematic Review ◽

Clinical Trials ◽

Low Back Pain ◽

Back Pain ◽

Chronic Low Back Pain ◽

Randomized Clinical Trials ◽

Extracorporeal Shock Wave Therapy ◽

Low Back ◽

Shock Wave Therapy ◽

Extracorporeal Shock Wave

Background: Extracorporeal Shock Wave Therapy (ESWT) has become a popular tool to treat musculoskeletal disorders and chronic low back pain. Aim of the study: To review the current scientific literature and assess the utility of ESWT in treating chronic low back pain. Methods: This systematic review was conducted from November 2019 to January 2020. Its purpose was to determine what the effectiveness is of the various forms of ESWT for the treatment of chronic low back pain. The critical review of the literature on the use of ESWT in chronic low back was made using the scientifically recognized medical databases PubMed, MEDLINE, Physiotherapy Evidence Database (PEDro) and Web of Science Core Collection. There was no restriction by date. Exclusion criteria were experimental, in vitro, animal, review, case reports, non-randomized clinical trials or studies with healthy participants. All articles written in languages other than English have also been excluded. Results: Six studies were included in the final analysis. According to the applied PEDro classification, the average scoring for the studies was 4.83, which indicates overall low quality of the presented reports. However, this result appeared closer to the moderate (acceptable) quality range (6-8 points) than to the unacceptable range (0-2 points). Conclusion: Based on the findings in the analyzed articles, ESWT promises to be an efficient and useful procedure in chronic low back pain treatment. Unfortunately, the level of evidence is relatively weak because there are a limited number of published studies related to ESWT and the final score in the PEDro classification was low. Together, these results indicate the need for further high quality randomized clinical trials.

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