Differences in Gut Virome Related to Barrett Esophagus and Esophageal Adenocarcinoma

The relationship between viruses (dominated by bacteriophages or phages) and lower gastrointestinal (GI) tract diseases has been investigated, whereas the relationship between gut bacteriophages and upper GI tract diseases, such as esophageal diseases, which mainly include Barrett’s esophagus (BE) and esophageal adenocarcinoma (EAC), remains poorly described. This study aimed to reveal the gut bacteriophage community and their behavior in the progression of esophageal diseases. In total, we analyzed the gut phage community of sixteen samples from patients with esophageal diseases (six BE patients and four EAC patients) as well as six healthy controls. Differences were found in the community composition of abundant and rare bacteriophages among three groups. In addition, the auxiliary metabolic genes (AMGs) related to bacterial exotoxin and virulence factors such as lipopolysaccharides (LPS) biosynthesis proteins were found to be more abundant in the genome of rare phages from BE and EAC samples compared to the controls. These results suggest that the community composition of gut phages and functional traits encoded by them were different in two stages of esophageal diseases. However, the findings from this study need to be validated with larger sample sizes in the future.

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INTERVENTIONAL TRAINING MODEL FOR FLEXIBLE ENDOSCOPY IN POSTOPERATIVELY ALTERED ANATOMY OF THE UPPER GI TRACT

10.1055/s-0040-1704783 ◽

2020 ◽

Author(s):

K Koch ◽

U Schweizer ◽

B Mothes ◽

D Wichmann ◽

KE Grund

Keyword(s):

Training Model ◽

Flexible Endoscopy ◽

Gi Tract ◽

Upper Gi ◽

Upper Gi Tract

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Direct visualization of drug behaviors in the upper GI tract via magnetically controlled capsule endoscopy

VideoGIE ◽

10.1016/j.vgie.2021.04.004 ◽

2021 ◽

Author(s):

Yuan-Chen Wang ◽

Jun Pan ◽

Bin Jiang ◽

Yang-Yang Qian ◽

Xiao-Ou Qiu ◽

...

Keyword(s):

Capsule Endoscopy ◽

Direct Visualization ◽

Gi Tract ◽

Upper Gi ◽

Upper Gi Tract

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Artificial intelligence in the upper GI tract: the future is fast approaching

Gastrointestinal Endoscopy ◽

10.1016/j.gie.2021.01.012 ◽

2021 ◽

Author(s):

Alanna Ebigbo ◽

Helmut Messmann

Keyword(s):

Artificial Intelligence ◽

Gi Tract ◽

Upper Gi ◽

The Future ◽

Upper Gi Tract

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0570 Apnea-Hypopnea Index is Positively Correlated with Mood Disturbance

SLEEP ◽

10.1093/sleep/zsaa056.567 ◽

2020 ◽

Vol 43 (Supplement_1) ◽

pp. A218-A219

Author(s):

K M Stubbers ◽

S S Thosar ◽

M P Butler ◽

N P Bowles ◽

A W McHill ◽

...

Keyword(s):

Diagnostic Criteria ◽

Mood State ◽

Mood Disturbance ◽

Apnea Hypopnea Index ◽

Uncomplicated Hypertension ◽

Total Mood Disturbance ◽

Obstructive Sleep ◽

Sleep Schedule ◽

The Relationship ◽

Larger Sample

Abstract Introduction The prevalence of mood disorders such as depression is higher in individuals with obstructive sleep apnea (OSA). Previous studies have found no significant correlation between the apnea-hypopnea index (AHI) and measures of mood and have only included participants who met diagnostic criteria for OSA. The current analysis sought to determine whether mood correlated with AHI in individuals with any AHI values including those that did not meet diagnostic criteria for OSA. Methods 31 volunteers were studied (BMI=29.2±1.0 kg/m2, mean±SE), free from medication and without psychiatric illness or chronic medical conditions with the exception of untreated OSA, uncomplicated hypertension (BP<160/100), or obesity. Following 1-3 weeks of an 8h habitual at home sleep schedule, participants completed the POMS-Brief questionnaire (POMS-B) to assess mood after undergoing overnight polysomnography to determine AHI. Total mood disturbance (TMD) scores were calculated by adding the scores on the POMS-B for each mood state subscale and subtracting the score for vigor-activity. Results The average AHI was 15.3±3.1 (range of 1.1-74.1) events per hour. The average POMS-B TMD score was 21±1.5 (range of 4-46). There was a significant correlation between the POMS-B TMD score and AHI (p=0.037, r2=0.14). This result was also seen in only those individuals with AHI scores >5 (p=0.002, r2=0.4). Conclusion In this sample, individuals with higher AHI values displayed higher TMD scores. These results differ from previous data that showed no significant correlation between AHI and TMD. This is the first analysis to demonstrate a correlation between TMD and AHI while including individuals who didn’t meet diagnostic criteria for OSA. However, the relationship between AHI and TMD was also significant in those with AHI>5. More data on these measures with larger sample sizes and a more equal representation of AHI values should be gathered to provide additional evidence for this relationship. Support: Support NIH R01-HL125893; CTSA UL1TR000128, R21HL140377

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