Dementia-Free Older Adults with Subjective Cognitive Impairment Show Lower Mood and No Deficits of Spontaneous Memory Retrieval

The aim of the present study was to investigate whether spontaneous retrieval deficits could be found in individuals with Subjective Cognitive Impairment (SCI). The sample consisted of 52 participants over 65 years of age (mean age = 76.00; SD = 7.48) with 11 males. We asked 26 individuals with SCI and 26 individuals without SCI to perform a prospective memory (PM) task that had previously demonstrated spontaneous retrieval deficits in individuals with Mild Cognitive Impairment. The results did not demonstrate the expected differences in a PM task based on spontaneous retrieval [ t(50) = −.05; p = .964, d = .01]. However, participants’ mood did predict their subjective memory complaints ( β = −.51; p < .001) and their subjective assessment of their future memory performance ( r = −.38; p < .01). The findings are in line with numerous studies which have shown that SCI is more related to mood disturbance than to objective cognitive functioning.

NCOG-43. RELATIONSHIPS BETWEEN MOOD DISTURBANCE, SYMPTOM INTERFERENCE, AND DISEASE PROGRESSION IN GLIOMA PATIENTS

Cross-sectional studies indicate that patients with gliomas report significant depressive/anxiety symptoms and symptom-related interference with daily activities at diagnosis and throughout the illness trajectory. Our study aimed to explore relationships between these mood disturbances and symptom interference with respect to progressive disease (PD) in glioma patients. Demographic, clinical characteristics, MDASI-Brain Tumor (interference items), and PROMIS Anxiety and Depression Short-Forms were collected at the time of imaging surveillance, before discussing imaging results. Comparisons between patients with/without PD and respective change scores were calculated at study entry and at subsequent assessments. Independent t-tests, Chi-square tests, and paired sample t-tests were used to report results. The sample included 438 glioma patients (62% male, 84% Caucasian, 82% high-grade) with median age of 51 years (range 18-82); 42% had PD with 60% reporting past recurrence(s); 45% had poor Karnofsky Performance Status (KPS); and median time from diagnosis was 2 years (range: 0-30). On average, patients with PD on imaging at time of assessment reported significantly greater anxiety (p = 0.008), depression (p &lt; 0.001), and symptom interference (p &lt; 0.001) than those with stable disease. Additionally, more patients with PD reported moderate-severe anxiety (25%) and depression (22%) than patients with stable disease (15% and 12%, respectively). When evaluating change scores, patients with PD reported worse symptom interference (p &lt; 0.001) but stable mood disturbance, while patients with stable disease reported improved depression (p = 0.018) and unchanged anxiety symptoms compared to baseline. Although mood disturbance is higher for patients with PD, some of these patients do not experience worsening, but rather a continuation of ongoing psychological symptoms, which may portend a worse illness trajectory. Identifying these patients early in this trajectory to evaluate potential biologic correlates between mood and prognosis is warranted to validate these findings.

QOLP-37. MOOD DISTURBANCE IN PATIENTS WITH CENTRAL NERVOUS SYSTEM (CNS) TUMORS DURING THE COVID-19 PANDEMIC

BACKGROUND Primary CNS tumors are associated with uncertainty likely contributing to mood disturbance that is common throughout the disease trajectory. The intersection of the COVID-19 pandemic with a CNS tumor diagnosis may further impact the anxiety/depression experienced in this population. This study assessed key anxiety/depression symptoms in patients with CNS tumors prior to and during the COVID year. METHODS Patient reported outcomes (PROs), including the PROMIS Anxiety and Depression Short Forms and EQ-5D-3L, were collected at the time of clinical or telehealth evaluation from the COVID year (March 2020-February 2021) and were compared to assessments through February 2020 (a NOB-normative sample), reflecting what we would typically see in our regular clinic evaluations. RESULTS The COVID sample (N = 178) was primarily White (82%), male (55%), median age of 45 (range 18–79), and KPS ³ 90 (50%). The majority had high grade (70%) brain (83%) tumors with ³ 1 prior recurrence (60%) and 25% were on active treatment. Visits were primarily conducted via telehealth (64%) and 20% had progression at assessment. Compared to the NOB-normative sample, patients reported significantly higher depression scores (moderate-severe, 17% vs. 12%, p &lt; 0.05), but not anxiety (18% vs. 16%). Eleven percent reported both moderate-severe anxiety and depressive symptoms (8% pre-COVID). Overall health assessed by the EQ-5D-3L was similar to the normative sample in all dimensions, apart from impact of moderate/extreme mood disturbance, which was more prevalent in the COVID year (53% vs. 43%, p &lt; 0.05%). CONCLUSION Patients with CNS tumors are at risk for significant symptoms of depression and anxiety; this risk was heightened during the COVID year. Further evaluation of clinical factors associated with risk are underway. These findings highlight the need for assessments and interventions that can be administered via telehealth to address the mental health needs of this vulnerable population. Radiobiology

Repercussion of Academic Stress on Vital Parameters among Medical Students of Ayub Medical College Abbottabad

OBJECTIVES: An increased stress is a common cause of mental fatigue and physical consumption among medical students. Therefore, the purpose of this study was to assess the effect of stress on vital parameters during students’ examination and to highlight the importance of personal well being among medical students. METHODOLOGY: The major aim of this study was to assess the effect of academic stress on vital parameters in medical students. This study was carried out in Ayub Medical College, Abbottabad in September to October 2018. The subjects selected for the study were final year MBBS students. Data was collected before and during the examinations. After taking their due consent, physical parameters such as blood pressure (both systolic and diastolic), heart rate were measured and psychological parameters like perceived stress and total mood disturbance were evaluated. Data was analyzed by using SPSS-22. RESULTS: Parameters like blood pressure (both systolic and diastolic) and total mood disturbance score with a p-value of <.01 showed significant difference during examination. However other variables like age, height, weight, BMI, heart rate, and perceived stress score showed no significant difference. CONCLUSION: The study concludes that students during examinations were under pressure which resulted in anxiety and stress. Total Mood Disturbance is considered a more reliable and prominent factor in interpretation of a student's stressed and disturbed state. It is more closely related to the stress state of students than any other.

Impact of 10-Min Daily Yoga Exercises on Physical and Mental Discomfort of Home-Office Workers During COVID-19

Objective Evaluate the effects of 10 min/day of yoga for 1 month on musculoskeletal discomfort and mood disturbance of home-office workers. Background The COVID-19 pandemic forced many people to switch to teleworking. The abrupt change from an office setting to an improvised home-office may negatively affect the musculoskeletal and emotional health of workers. By providing mental and physical exercises, yoga may be effective in reducing adverse effects. Method Fifty-four participants (42 women, 12 men) followed a 1-month yoga program, while 40 participants (26 women, 14 men) continued with their common work routine. The Cornell Musculoskeletal Discomfort Questionnaire was used to evaluate severity, interference with work and frequency of pain, and to obtain a total discomfort score for 25 body areas. Mood disturbance was evaluated with the Profile of Mood States questionnaire. Both groups completed both questionnaires, before and after the experimentation period. Results After 1 month, for the yoga group only, significant reductions were observed in the discomfort of eyes, head, neck, upper and lower back, right wrist, and hips/buttocks, as well as reductions in discomfort severity, frequency and interference for the neck, upper and lower back. Total mood disturbance was also significantly reduced for the yoga group only. No favorable changes occurred for the control group. Conclusion The yoga intervention program appears to reduce musculoskeletal discomfort and mood disturbance of home-office workers. Application Sedentary workers may benefit from 10 min/day of yoga during the workday to attenuate potential physical and emotional discomfort during the current pandemic and beyond.

Proof-of-Concept and Test-Retest Reliability Study of Psychological and Physiological Variables of the Mental Fatigue Paradigm

This study provided a proof-of-concept and test–retest reliability of measures frequently used to assess a mental fatigue paradigm. After familiarization, 28 healthy men performed (40-min) the Rapid Visual Information Processing (RVP) test in a test–retest design, having mental fatigue sensation, motivation, emotional arousal, total mood disturbance, and electroencephalography (EEG) in the prefrontal cortex measured before and after the test. EEG was recorded during a 3-min rest so that the power spectral density of theta (3–7 Hz) and alpha (8–13 Hz) bands was calculated. Pre-to-post RVP test changes in psychological and physiological domains were compared (paired-T tests), and absolute (standard error of measurement (SEM) and minimal difference (MD)) and relative reliability (intraclass correlation coefficient (ICC)) were calculated. The RVP test induced an increase (p < 0.05) in mental fatigue sensation (120.9% (109.4; 132.4)) and total mood disturbance (3.5% (−6.3; 13.3)), and a decrease in motivation (−7.1% (−9.2; −5.1)) and emotional arousal (−16.2% (−19.1; −13.2)). Likewise, EEG theta (59.1% (33.2; 85.0); p < 0.05), but not alpha band, increased due to RVP test. All psychophysiological responses showed poor-to-moderate relative reliability. Changes in mental fatigue sensation and motivation were higher than SEM and MD, but changes in EEG theta band were higher only than SEM. Mental fatigue sensation, motivation, and EEG theta band were sensitive to distinguish a mental fatigue paradigm despite true mental fatigue effects on theta activity may be trivial.

Variations in the Mood States during the Different Phases of COVID-19’s Lockdown in Young Athletes

The pandemic caused by SARS-CoV-2 led to a situation of home lockdown. Competitions, training, and sports activities were canceled for much of this period. This situation could have affected the physical and mental health and the mood states of young athletes. The aim of the study was to evaluate the variations in the mood states of young athletes of a highly competitive level during the different phases of lockdown in. The mood states of 45 Spanish youth athletes confined during the 10-week lockdown due to the COVID-19 pandemic -19 were assessed, using the Spanish-translated version of the POMS questionnaire, at the start of the home lockdown and at the start and at the end of the partial lockdown. The Total Mood Disturbance scores at week 10 were lower than those obtained in week 1 (pBonferroni = 0.031). The depression scores at week 6 (pBonferroni = 0.048) and at week 10 (pBonferroni < 0.001) were lower than those obtained in week 1. The confusion scores at week 10 were lower than those obtained in week 1 (pBonferroni = 0.002). These variations differed between team and individual sports. In conclusion, the lockdown produced changes in the young athletes’ mood states that should be considered when trying to optimize their physical and mental performance.

A-93 Comorbidity or Concussion: Can we Tell the Difference?

Objective To evaluate athletes with comorbid mood disturbances at baseline (without recent concussion) compared to those without mood symptoms tested post-concussion. This study is predicated upon previous findings showing that athletes with comorbidity at baseline demonstrate greater neurocognitive impairment, and report greater symptomatology, than healthy controls. It is currently unclear how athletes with comorbidity at baseline compare to athletes post-concussion. Method 119 college athletes completed objective neurocognitive testing, including measures of depression and anxiety. Athletes were separated into two groups: those with symptoms of comorbid anxiety/depression at baseline (n = 61,M = 35,F = 26) and those without such mood symptoms tested post-concussion (n = 58,M = 52,F = 6). All post-concussion athletes were tested within 14 days of injury. There were no overlapping athletes in these groups. Groups were compared on neurocognitive performance on mean z-score composites of Attention/Processing Speed (A/PS) and Memory. Results Regression results revealed that, on the A/PS composite, the Baseline Comorbid group (M = −0.15,SD = 0.64) did not differ significantly from the Post-Concussion Healthy Mood group (M = 0.05,SD = 0.62), t(117) = 1.75,p = 0.08, though there was a small effect size, d = 0.32. Additionally, on the Memory composite, the Baseline Comorbid Group (M = -0.12,SD = 0.69) did not differ from the Post-Concussion Healthy Mood group (M = -0.11,SD = 0.84), t(117) = 0.08,p = 0.94,d = 0.01. Conclusions These results suggest that athletes with comorbid anxiety/depression tested at baseline perform similarly to recently concussed athletes without mood disturbance, on objective neurocognitive measures. Thus, despite not experiencing recent injury, athletes with comorbidity present with similar neurocognitive profiles as athletes with recent concussions. These findings highlight the impact of comorbid mood disturbance on cognitive performance and demonstrate the importance of accounting for mood symptomatology when conducting neuropsychological assessments.

Consecutive Nights of Moderate Sleep Loss Does Not Affect Mood in Healthy Young Males

Sleep loss causes mood disturbance in non-clinical populations under severe conditions, i.e., two days/nights of sleep deprivation or a week of sleep restriction with 4–5 h in bed each night. However, the effects of more-common types of sleep loss on mood disturbance are not yet known. Therefore, the aim of this study was to examine mood disturbance in healthy adults over a week with nightly time in bed controlled at 5, 6, 7, 8 or 9 h. Participants (n = 115) spent nine nights in the laboratory and were given either 5, 6, 7, 8 or 9 h in bed over seven consecutive nights. Mood was assessed daily using the Profile of Mood States (POMS-2). Mixed-linear effects models examined the effect of time in bed on total mood disturbance and subscales of anger-hostility, confusion-bewilderment, depression-dejection, fatigue-inertia, tension-anxiety, vigour-activity and friendliness. There was no effect of time in bed on total mood disturbance (F(4, 110.42) = 1.31, p = 0.271) or any of the subscales except fatigue-inertia. Fatigue-inertia was higher in the 5 h compared with the 9 h time in bed condition (p = 0.012, d = 0.75). Consecutive nights of moderate sleep loss (i.e., 5–7 h) does not affect mood but does increase fatigue in healthy males.