TXI (Texture and Color Enhancement Imaging) for Serrated Colorectal Lesions

Background and aim: Olympus Corporation released the texture and color enhancement imaging (TXI) technology as a novel image-enhancing endoscopic technique. We investigated the effectiveness of TXI in the imaging of serrated colorectal polyps, including sessile serrated lesions (SSLs). Methods: Serrated colorectal polyps were observed using white light imaging (WLI), TXI, narrow-band imaging (NBI), and chromoendoscopy with and without magnification. Serrated polyps were histologically confirmed. TXI was compared with WLI, NBI, and chromoendoscopy for the visibility of the lesions without magnification and for that of the vessel and surface patterns with magnification. Three expert endoscopists evaluated the visibility scores, which were classified from 1 to 4. Results: Twenty-nine consecutive serrated polyps were evaluated. In the visibility score without magnification, TXI was significantly superior to WLI but inferior to chromoendoscopy in the imaging of serrated polyps and the sub-analysis of SSLs. In the visibility score for vessel patterns with magnification, TXI was significantly superior to WLI and chromoendoscopy in the imaging of serrated polyps and the sub-analysis of SSLs. In the visibility score for surface patterns with magnification, TXI was significantly superior to WLI but inferior to NBI in serrated polyps and in the sub-analysis of SSLs and hyperplastic polyps. Conclusions: TXI provided higher visibility than did WLI for serrated, colorectal polyps, including SSLs.

Wrinkling on Stimuli-Responsive Functional Polymer Surfaces as a Promising Strategy for the Preparation of Effective Antibacterial/Antibiofouling Surfaces

Biocompatible smart interfaces play a crucial role in biomedical or tissue engineering applications, where their ability to actively change their conformation or physico-chemical properties permits finely tuning their surface attributes. Polyelectrolytes, such as acrylic acid, are a particular type of smart polymers that present pH responsiveness. This work aims to fabricate stable hydrogel films with reversible pH responsiveness that could spontaneously form wrinkled surface patterns. For this purpose, the photosensitive reaction mixtures were deposited via spin-coating over functionalized glasses. Following vacuum, UV, or either plasma treatments, it is possible to spontaneously form wrinkles, which could increase cell adherence. The pH responsiveness of the material was evaluated, observing an abrupt variation in the film thickness as a function of the environmental pH. Moreover, the presence of the carboxylic acid functional groups at the interface was evidenced by analyzing the adsorption/desorption capacity using methylene blue as a cationic dye model. The results demonstrated that increasing the acrylic acid in the microwrinkled hydrogel effectively improved the adsorption and release capacity and the ability of the carboxylic groups to establish ionic interactions with methylene blue. Finally, the role of the acrylic acid groups and the surface topography (smooth or wrinkled) on the final antibacterial properties were investigated, demonstrating their efficacy against both gram-positive and gram-negative bacteria model strains (E. coli and S. Aureus). According to our findings, microwrinkled hydrogels presented excellent antibacterial properties improving the results obtained for planar (smooth) hydrogels.

Cladribine Alters Immune Cell Surface Molecules for Adhesion and Costimulation: Further Insights to the Mode of Action in Multiple Sclerosis

Cladribine (CLAD) is a deoxyadenosine analogue prodrug which is given in multiple sclerosis (MS) as two short oral treatment courses 12 months apart. Reconstitution of adaptive immune function following selective immune cell depletion is the presumed mode of action. In this exploratory study, we investigated the impact of CLAD tablets on immune cell surface molecules for adhesion (CAMs) and costimulation (CoSs) in people with MS (pwMS). We studied 18 pwMS who started treatment with CLAD and 10 healthy controls (HCs). Peripheral blood mononuclear cells were collected at baseline and every 3 months throughout a 24-month period. We analysed ICAM-1, LFA-1, CD28, HLADR, CD154, CD44, VLA-4 (CD49d/CD29), PSGL-1 and PD-1 with regard to their expression on B and T cells (T helper (Th) and cytotoxic T cells (cT)) and surface density (mean fluorescence intensity, MFI) by flow cytometry. The targeted analysis of CAM and CoS on the surface of immune cells in pwMS revealed a higher percentage of ICAM-1 (B cells, Th, cT), LFA-1 (B cells, cT), HLADR (B cells, cT), CD28 (cT) and CD154 (Th). In pwMS, we found lower frequencies of Th and cT cells expressing PSGL-1 and B cells for the inhibitory signal PD-1, whereas the surface expression of LFA-1 on cT and of HLADR on B cells was denser. Twenty-four months after the first CLAD cycle, the frequencies of B cells expressing CD44, CD29 and CD49d were lower compared with the baseline, together with decreased densities of ICAM-1, CD44 and HLADR. The rate of CD154 expressing Th cells dropped at 12 months. For cT, no changes were seen for frequency or density. Immune reconstitution by oral CLAD was associated with modification of the pro-migratory and -inflammatory surface patterns of CAMs and CoSs in immune cell subsets. This observation pertains primarily to B cells, which are key cells underlying MS pathogenesis.

Surface plastic flow of 3D printed PLA in tribological study of surface patterned polymer

The potential of three-dimensional (3D) printing in polymer tribology is poorly explored. Material alignment and composition plays a vital role in altering the friction and wear characteristics of 3D printed materials. In the current study 3D patterns using fused deposition modeling are used to print advanced tribo-composites. Two different surface patterns (line and circular) are provided through 3D printing using white and silver Poly Lactic Acid (PLA). The deformation and the distribution of white and silver PLA over the samples surface are observed after the wear test. Results showed that the coefficient of friction is not being influenced by changing in the surface pattern. However, the wear rate increased for samples with line patterns on the contact surface, since the plastic flow was more significant in this case. Moreover, the filling factor exhibited an influence on increasing the plastic flow of the contact surface in case of the samples with line pattern.

Heat Exchange in Staggered Threaded Pipe Banks with Similar Developed Surface Patterns under Natural Draft Conditions

Helical pipes with similar developed surface patterns efficiently operate under forced convection conditions. The available literature describes their essential advantages over the tubes of a round-ribbed profile and the possibility of their application as a heat-exchanging section for the air-cooling unit. However, the peculiarities of the operation of such units require checking an opportunity for the use of helical pipes with similar developed surface patterns under natural draft conditions. The purpose of the research is to get new data on the flow structure in the intertube space of the staggered banks of such pipes under natural draft conditions. These data are required for the in-depth analysis of the appropriateness of the use of such pipes for “dry” air cooling systems. The methods of investigation included the use of the academic licensed software package ANSYS Student for numerical computations. It was established that the heat exchange in ribbed pipes under natural draft conditions is specified first of all by the parameters of the staggered bank (longitudinal and transversal pitches of the arrangement of pipes in the bank) and the geometric parameters of the pipes, in particular the pitch between the humps and the dents on the tube surface that form its helical surface. Design ratios were suggested for the determination of the averaged heat exchange in the staggered banks of the single-thread helical pipes with similar developed surface patterns. It was shown that the pitch characteristics of the banks have the greatest effect on the similarity equation. A preliminary validation was carried out for the methods adopted for the design of helical pipes and the known methods used for the computation of the staggered banks of smooth cylindrical pipes. The obtained research data can be used for the evaluation of the intensification of the heat exchange and for the flow analysis in order to increase the efficiency of the heat-exchange equipment.

ADVANCES IN TECHNIQUES AND APPLICATIONS OF RUBBER SURFACE GRAFTING MODIFICATION

ABSTRACT To meet the requirement in the application of medical devices, composites, biomaterials, corrosion resistance, and selective adsorptions, rubber surface modification is usually indispensable. Grafting treatment is one of most significate treatment methods. In this paper, we focus on rubber surface grafting modification, including grafting techniques and applications. Different grafting methods—including monomer grafting polymerization and coupling reaction—are covered and compared briefly. The related applications of surface grafting modification techniques, such as improving compatibility of waste rubber as fillers, hydrophobicity and lipophilicity of sponge rubber for oil–water separation, biocompatibility of rubber in the medical field, and forming surface patterns, are demonstrated in detail. The new research directions of surface grafting techniques as well as main challenges in application are also discussed.

Wear of 17-4 PH Stainless Steel Patterned Surfaces Fabricated Using Selective Laser Melting

The recent developments in additive manufacturing (AM) are providing unprecedented opportunities in various fields, including the fabrication of advanced materials for tribological applications. The present work describes the results of an exploratory study focused on the analysis of 17-4 PH steel surfaces obtained using selective laser melting (SLM). In particular, the study includes the analysis of baseline (as-produced) and textured steel surfaces. Surface texturing comprises hexagonal prism structures (with or without dimples) arranged in a honeycomb pattern with 50 µm or 100 µm gap spacing. Starting from the minimum printing size enabled by the 3D printing platform, various textures are prepared by scaling up the characteristic dimensions of the prisms up to 500%. The obtained surface patterns are characterized (qualitatively and quantitatively) using a non-contact computerized numerical control (CNC) measuring system. The coefficient of friction (COF) was investigated using a Ball-on-Disk configuration using bearing steel balls as counterparts. For a fixed sliding speed, different contact loads and sliding radii were considered, while the tests were carried out in either dry or lubricant-impregnated conditions. The results of wear tests in both dry and lubricated conditions indicated that the baseline samples are provided with lower COF compared to the textured ones. For the latter, neither the gap spacing nor the presence of dimples led to significant variations in the COF. However, in lubricated conditions, the values of the COF for baseline and textured surfaces were closer and much smaller. In particular, the results provide clear indications regarding reducing the gap between prisms, which had a beneficial effect on the COF in lubricated conditions. Similarly, sensitivity to dimples was quite remarkable, with a reduction in the COF of about 30% when the larger gap spacing between the prisms was used.

Undergraduate creative arts students’ perceptions and attitudes toward disability: Advancing a critical disability studies informed curriculum

This study reports on the unanticipated findings of a small-scale, evaluative research project. Further to a pilot iteration, a cohort of undergraduate art students engaged with an immersive, inclusive arts curriculum informed by critical disability studies. Students’ perceptions and attitudes about disability were recorded at the outset and conclusion of the pedagogical project, through a qualitative questionnaire. Thematic analysis was employed to surface patterns in the cohort’s responses at both points in their learning journey. While the findings evidenced the anticipated shift from individualized perspectives about disability to an increasingly social, interactional perspective, the full extent of the medicalized gaze and internalized ableism at the outset of the study was unanticipated. This realization has been influential in developing the pedagogical approach and the framing of the content taught, and has exemplified both the potential and the need to learn about disability, disablement and diversity through art education.