scholarly journals 7-Methoxytacrine-Adamantylamine Heterodimers as Cholinesterase Inhibitors in Alzheimer’s Disease Treatment — Synthesis, Biological Evaluation and Molecular Modeling Studies

Molecules ◽  
2013 ◽  
Vol 18 (2) ◽  
pp. 2397-2418 ◽  
Author(s):  
Katarina Spilovska ◽  
Jan Korabecny ◽  
Jan Kral ◽  
Anna Horova ◽  
Kamil Musilek ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Molecular Modeling ◽  
Cholinesterase Inhibitors ◽  
Biological Evaluation ◽  
Disease Treatment ◽  
Modeling Studies ◽  
Molecular Modeling Studies

Multifunctional Analogs of Kynurenic Acid for the Treatment of Alzheimer’s Disease: Synthesis, Pharmacology, and Molecular Modeling Studies

2017 ◽  
Vol 8 (12) ◽  
pp. 2667-2675 ◽  
Author(s):  
Girdhar Singh Deora ◽  
Srinivas Kantham ◽  
Stephen Chan ◽  
Satish N. Dighe ◽  
Suresh K. Veliyath ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Molecular Modeling ◽  
Kynurenic Acid ◽  
Modeling Studies ◽  
Molecular Modeling Studies

Synthesis, biological evaluation and molecular modeling studies of phthalazin-1(2H)-one derivatives as novel cholinesterase inhibitors

RSC Advances ◽  
2016 ◽  
Vol 6 (52) ◽  
pp. 46170-46185 ◽  
Author(s):  
Noemí Vila ◽  
Pedro Besada ◽  
Dolores Viña ◽  
Mattia Sturlese ◽  
Stefano Moro ◽  
...  
Keyword(s):  
Molecular Modeling ◽  
Cholinesterase Inhibitors ◽  
Biological Evaluation ◽  
Inhibitory Potency ◽  
Structural Modifications ◽  
Modeling Studies ◽  
Molecular Modeling Studies

A series of donepezil analogues based on phthalazin-1(2H)-one scaffold was studied as hChEIs. The biological results revealed that the structural modifications proposed significantly affected ChE inhibitory potency as well as selectivity AChE/BuChE.

scholarly journals Synthesis, biological evaluation and molecular modeling studies of substituted N-benzyl-2-phenylethanamines as cholinesterase inhibitors

2020 ◽  
Vol 44 (22) ◽  
pp. 9466-9476
Author(s):  
Florencia Carmona-Viglianco ◽  
Daniel Zaragoza-Puchol ◽  
Oscar Parravicini ◽  
Adriana Garro ◽  
Ricardo D. Enriz ◽  
...  
Keyword(s):  
Molecular Modeling ◽  
Cholinesterase Inhibitors ◽  
Reductive Amination ◽  
Biological Evaluation ◽  
Modeling Studies ◽  
Molecular Modeling Studies

4’-O-methylnorbelladine and other non-natural halogenated protoalkaloids were synthesized by reductive amination. They exerted moderate to good inhibition of cholinesterases which was adequately explained by molecular modeling studies.

New semicarbazones as gorge-spanning ligands of acetylcholinesterase and potential new drugs against Alzheimer’s disease: Synthesis, molecular modeling, NMR, and biological evaluation

2017 ◽  
Vol 36 (15) ◽  
pp. 4099-4113 ◽  
Author(s):  
Denise Cristian Ferreira Neto ◽  
Josélia Alencar Lima ◽  
Joyce Sobreiro Francisco Diz de Almeida ◽  
Tanos Celmar Costa França ◽  
Claudia Jorge do Nascimento ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Molecular Modeling ◽  
Biological Evaluation ◽  
New Drugs
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