Synthesis, biological evaluation and molecular modeling studies of phthalazin-1(2H)-one derivatives as novel cholinesterase inhibitors

RSC Advances ◽  
2016 ◽  
Vol 6 (52) ◽  
pp. 46170-46185 ◽  
Author(s):  
Noemí Vila ◽  
Pedro Besada ◽  
Dolores Viña ◽  
Mattia Sturlese ◽  
Stefano Moro ◽  
...  
Keyword(s):  
Molecular Modeling ◽  
Cholinesterase Inhibitors ◽  
Biological Evaluation ◽  
Inhibitory Potency ◽  
Structural Modifications ◽  
Modeling Studies ◽  
Molecular Modeling Studies

A series of donepezil analogues based on phthalazin-1(2H)-one scaffold was studied as hChEIs. The biological results revealed that the structural modifications proposed significantly affected ChE inhibitory potency as well as selectivity AChE/BuChE.

scholarly journals Synthesis, biological evaluation and molecular modeling studies of substituted N-benzyl-2-phenylethanamines as cholinesterase inhibitors

2020 ◽  
Vol 44 (22) ◽  
pp. 9466-9476
Author(s):  
Florencia Carmona-Viglianco ◽  
Daniel Zaragoza-Puchol ◽  
Oscar Parravicini ◽  
Adriana Garro ◽  
Ricardo D. Enriz ◽  
...  
Keyword(s):  
Molecular Modeling ◽  
Cholinesterase Inhibitors ◽  
Reductive Amination ◽  
Biological Evaluation ◽  
Modeling Studies ◽  
Molecular Modeling Studies

4’-O-methylnorbelladine and other non-natural halogenated protoalkaloids were synthesized by reductive amination. They exerted moderate to good inhibition of cholinesterases which was adequately explained by molecular modeling studies.

Synthesis, Biological Evaluation and Molecular Modeling Studies of New 2,3-Diheteroaryl Thiazolidin-4-Ones as NNRTIs

2015 ◽  
Vol 86 (5) ◽  
pp. 1285-1291 ◽  
Author(s):  
Utsab Debnath ◽  
Saroj Verma ◽  
Pankaj Singh ◽  
Kavita Rawat ◽  
Satish K. Gupta ◽  
...  
Keyword(s):  
Molecular Modeling ◽  
Biological Evaluation ◽  
Modeling Studies ◽  
Molecular Modeling Studies
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