Enantioselective Synthesis of Chromanones Bearing an α,α-Disubstituted α-Amino Acid Moiety via Decarboxylative Michael Reaction
Keyword(s):
In this manuscript, a novel, decarboxylative Michael reaction between α-substituted azlactones and chromone-3-carboxylic acids is described. The reaction proceeds in a sequence Michael addition followed by decarboxylative deprotonation, and it results in the formation of chromanones bearing an azlactone structural unit. The possibility of transforming an azlactone moiety into a protected α,α-disubstituted α-amino acid derivative is also demonstrated.
2016 ◽
Vol 22
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pp. 16429-16432
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2016 ◽
Vol 358
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pp. 195-200
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2021 ◽
Vol 98
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pp. 100004
2011 ◽
Vol 378
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pp. 531-540
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2013 ◽
Vol 54
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pp. 1444-1448
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Vol 74
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pp. AB11