scholarly journals Comparison of Intraocular Pressure, Blood Pressure, Ocular Perfusion Pressure and Blood Flow Fluctuations During Dorzolamide Versus Timolol Add-On Therapy in Prostaglandin Analogue Treated Glaucoma Subjects

2012 ◽  
Vol 5 (3) ◽  
pp. 325-338 ◽  
Author(s):  
Ingrida Januleviciene ◽  
Lina Siaudvytyte ◽  
Vaida Diliene ◽  
Ruta Barsauskaite ◽  
Daiva Paulaviciute-Baikstiene ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Blood Flow ◽  
Intraocular Pressure ◽  
Perfusion Pressure ◽  
Prostaglandin Analogue ◽  
Ocular Perfusion Pressure ◽  
Ocular Perfusion ◽  
Flow Fluctuations

Inter-relationship between ocular perfusion pressure, blood pressure, intraocular pressure profiles and primary open-angle glaucoma: the Singapore Epidemiology of Eye Diseases study

2018 ◽  
Vol 102 (10) ◽  
pp. 1402-1406 ◽  
Author(s):  
Yih-Chung Tham ◽  
Sing-Hui Lim ◽  
Preeti Gupta ◽  
Tin Aung ◽  
Tien Y Wong ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Intraocular Pressure ◽  
Primary Open Angle Glaucoma ◽  
Perfusion Pressure ◽  
Open Angle Glaucoma ◽  
Eye Diseases ◽  
Open Angle ◽  
Ocular Perfusion Pressure ◽  
Ocular Perfusion ◽  
Relevant Covariates

ObjectiveTo elucidate the inter-relationship between ocular perfusion pressure (OPP), blood pressure (BP), intraocular pressure (IOP) profiles and primary open-angle glaucoma (POAG) in a multiethnic Asian population.MethodsParticipants were recruited from the Singapore Epidemiology of Eye Diseases Study and underwent standardised ocular and systemic examinations. POAG was defined according to the International Society for Geographical and Epidemiological Ophthalmology criteria. Logistic regression analyses with generalised estimating equation models were performed and used to account for correlation between eyes.ResultsA total of 9877 participants (19 587 eyes), including 213 POAG cases (293 eyes) were included. Eyes with lowest quartile levels of systolic OPP (SOPP <110 mm Hg) were 1.85 times (95% CI 1.16 to 2.95) likely to have POAG, compared with eyes with mid-range SOPP levels (123–137 mm Hg; third quartile), after adjusting for relevant covariates and IOP. Consistently, we found that lowest quartile of systolic BP (SBP <124 mm Hg) was 1.69 times (95% CI 1.08 to 2.66) likely to have POAG, compared with mid-range SBP levels (138–153 mm Hg; third quartile). Furthermore, the effect of lower SBP on POAG was more pronounced in eyes with IOP ≥21 mm Hg (OR 3.90; 95% CI 1.24 to 12.30). Both the mean and diastolic profiles of OPP and BP were not significantly associated with POAG, after adjusting for relevant covariates and IOP.ConclusionsIn this population-based sample of nearly 10 000 Asian individuals, we showed that low SOPP was associated with POAG. This association was potentially in part secondary to low SBP and high IOP. Our findings provide further clarity on the roles of OPP surrogates and BP profiles in POAG.

The Circadian Variations in Systemic Blood Pressure, Ocular Perfusion Pressure, and Ocular Blood Flow: Risk Factors for Glaucoma?

2008 ◽  
Vol 53 (6) ◽  
pp. 559-567 ◽  
Author(s):  
Adam Werne ◽  
Alon Harris ◽  
Danny Moore ◽  
Itay BenZion ◽  
Brent Siesky
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Blood Flow ◽  
Perfusion Pressure ◽  
Systemic Blood Pressure ◽  
Ocular Blood Flow ◽  
Ocular Perfusion Pressure ◽  
Circadian Variations ◽  
Systemic Blood ◽  
Ocular Perfusion
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