scholarly journals Clinical Efficacy and Safety of Sodium Thiosulfate in the Treatment of Uremic Pruritus: A Meta-Analysis of Randomized Controlled Trials

Toxins ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 769
Author(s):  
Ping-Hsun Lu ◽  
Hui-En Chuo ◽  
Ko-Lin Kuo ◽  
Jian-Fu Liao ◽  
Po-Hsuan Lu

Uremic pruritus is a distressful complication of chronic kidney disease and results in impaired quality of life and higher mortality rates. Intravenous sodium thiosulfate has been reported to alleviate pruritus in hemodialysis patients. We performed a systematic review and meta-analysis to estimate the efficacy of intravenous sodium thiosulfate in patients with uremic pruritus. A systematic search of electronic databases up to June 2021 was conducted for randomized controlled trials that evaluated the clinical effects of sodium thiosulfate in the management of patients with uremic pruritus. Two reviewers selected eligible articles and evaluated the risk of bias; the results of pruritus assessment and uremic pruritus-related laboratory parameters in selected studies were analyzed. There are four trials published between 2018 and 2021, which include 222 participants. The sodium thiosulfate group displayed significant decrease in the pruritus score (standardized mean difference = −3.52, 95% confidence interval = −5.63 to −1.41, p = 0.001), without a significant increase in the adverse effects (risk ratio = 2.44, 95% confidence interval = 0.37 to 15.99, p = 0.35) compared to the control group. Administration of sodium thiosulfate is found to be a safe and efficacious complementary therapy in improving uremic pruritus in patients with chronic kidney disease.

Nephron ◽  
2018 ◽  
Vol 139 (3) ◽  
pp. 197-210 ◽  
Author(s):  
Primploy Greeviroj ◽  
Thidarat Kitrungphaiboon ◽  
Pisut Katavetin ◽  
Kearkiat Praditpornsilpa ◽  
Somchai Eiam-Ong ◽  
...  

2013 ◽  
Vol 29 (5) ◽  
pp. 435-451 ◽  
Author(s):  
Dragana Nikolic ◽  
Shekoufeh Nikfar ◽  
Pooneh Salari ◽  
Manfredi Rizzo ◽  
Kausik K. Ray ◽  
...  

PLoS ONE ◽  
2020 ◽  
Vol 15 (5) ◽  
pp. e0233869
Author(s):  
Stephanie Thompson ◽  
Natasha Wiebe ◽  
Raj S. Padwal ◽  
Gabor Gyenes ◽  
Samuel A. E. Headley ◽  
...  

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