scholarly journals Origin and Spread of the Dengue Virus Type 1, Genotype V in Senegal, 2015–2019

Viruses ◽  
2021 ◽  
Vol 13 (1) ◽  
pp. 57
Author(s):  
Idrissa Dieng ◽  
Marielton dos Passos Cunha ◽  
Moussa Moïse Diagne ◽  
Pape Mbacké Sembène ◽  
Paolo Marinho de Andrade Zanotto ◽  
...  
Keyword(s):  
Maximum Likelihood ◽  
Dengue Virus ◽  
Southeast Asia ◽  
Bayesian Methods ◽  
Urban Environments ◽  
Present Evidence ◽  
Monophyletic Cluster ◽  
Western Africa ◽  
Genotype V

Dengue virus (DENV) is the most widespread arthropod-borne virus, with the number and severity of outbreaks increasing worldwide in recent decades. Dengue is caused by genetically distinct serotypes, DENV-1–4. Here, we present data on DENV-1, isolated from patients with dengue fever during an outbreak in Senegal and Mali (Western Africa) in 2015–2019, that were analyzed by sequencing the envelope (E) gene. The emergence and the dynamics of DENV-1 in Western Africa were inferred by using maximum likelihood and Bayesian methods. The DENV-1 grouped into a monophyletic cluster that was closely related to those from Southeast Asia. The virus appears to have been introduced directly into Medina Gounass (Suburb of Dakar), Senegal (location probability = 0.301, posterior = 0.76). The introduction of the virus in Senegal occurred around 2014 (95% HPD = 2012.88–2014.84), and subsequently, the virus moved to regions within Senegal (e.g., Louga and Fatick), causing intense outbreaks in the subsequent years. The virus appears to have been introduced in Mali (a neighboring country) after its introduction in Senegal. In conclusion, we present evidence that the outbreak caused by DENV-1 in urban environments in Senegal and Mali after 2015 was caused by a single viral introduction from Asia.

scholarly journals Adaptive Evolution of New Variants of Dengue Virus Serotype 1 Genotype V Circulating in the Brazilian Amazon

Viruses ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 689
Author(s):  
Geovani de Oliveira Ribeiro ◽  
Danielle Elise Gill ◽  
Edcelha Soares D’Athaide Ribeiro ◽  
Fred Julio Costa Monteiro ◽  
Vanessa S. Morais ◽  
...  
Keyword(s):  
Dengue Virus ◽  
Febrile Illness ◽  
Viral Pathogen ◽  
Virus Serotype ◽  
Serotype 1 ◽  
Invaluable Tool ◽  
Northern Brazil ◽  
Genotype V

Dengue virus (DENV) is a mosquito-borne viral pathogen that plagues many tropical-climate nations around the world, including Brazil. Molecular epidemiology is a growing and increasingly invaluable tool for understanding the dispersal, persistence, and diversity of this impactful virus. In this study, plasma samples (n = 824) from individuals with symptoms consistent with an arboviral febrile illness were analyzed to identity the molecular epidemiological dynamics of DENV circulating in the Brazilian state of Amapá. Twelve DENV type 1 (DENV-1) genomes were identified, which were phylogenetically related to the BR4 lineage of genotype V. Phylodynamics analysis suggested that DENV-1 BR-4 was introduced into Amapá around early 2010, possibly from other states in northern Brazil. We also found unique amino acids substitutions in the DENV-1 envelope and NS5 protein sequences in the Amapá isolates. Characterization of the DENV-1 BR-4 sequences highlights the potential of this new lineage to drive outbreaks of dengue in the Amazon region.

Molecular epidemiology of dengue in the Pacific: introduction of two distinct strains of dengue virus type-1 into Hawaii

2006 ◽  
Vol 100 (4) ◽  
pp. 327-336 ◽  
Author(s):  
A. Imrie ◽  
Z. Zhao ◽  
S. N. Bennett ◽  
P. Kitsutani ◽  
M. Laille ◽  
...  
Keyword(s):  
Dengue Virus ◽  
Molecular Epidemiology ◽  
Virus Type ◽  
The Pacific

scholarly journals Highly Selective Transmission Success of Dengue Virus Type 1 Lineages in a Dynamic Virus Population: An Evolutionary and Fitness Perspective

iScience ◽  
2018 ◽  
Vol 6 ◽  
pp. 38-51 ◽  
Author(s):  
Carmen Koo ◽  
Wei Ping Tien ◽  
Helen Xu ◽  
Janet Ong ◽  
Jayanthi Rajarethinam ◽  
...  
Keyword(s):  
Dengue Virus ◽  
Virus Type ◽  
Virus Population ◽  
Transmission Success

scholarly journals Large Dengue virus type 1 outbreak in Taiwan

2015 ◽  
Vol 4 (1) ◽  
pp. 1-3 ◽  
Author(s):  
Sheng-Fan Wang ◽  
Ko Chang ◽  
Ruo-Wei Lu ◽  
Wen-Hung Wang ◽  
Yen-Hsu Chen ◽  
...  
Keyword(s):  
Dengue Virus ◽  
Virus Type

scholarly journals Isolation of Ancestral Sylvatic Dengue Virus Type 1, Malaysia

2010 ◽  
Vol 16 (11) ◽  
pp. 1783-1785 ◽  
Author(s):  
Boon-Teong Teoh ◽  
Sing-Sin Sam ◽  
Juraina Abd-Jamil ◽  
Sazaly AbuBakar
Keyword(s):  
Dengue Virus ◽  
Virus Type

scholarly journals Novel Dengue Virus Type 1 from Travelers to Yap State, Micronesia

2006 ◽  
Vol 12 (2) ◽  
pp. 343-346 ◽  
Author(s):  
Yoko Nukui ◽  
Shigeru Tajima ◽  
Akira Kotaki ◽  
Mikako Ito ◽  
Tomohiko Takasaki ◽  
...  
Keyword(s):  
Dengue Virus ◽  
Virus Type ◽  
Yap State

scholarly journals High-throughput neutralization assay for multiple flaviviruses based on single-round infectious particles using dengue virus type 1 reporter replicon

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Mami Matsuda ◽  
Atsushi Yamanaka ◽  
Keigo Yato ◽  
Kentaro Yoshii ◽  
Koichi Watashi ◽  
...  
Keyword(s):  
Dengue Virus ◽  
Virus Type ◽  
High Throughput ◽  
Neutralization Assay

Analysis of Differentially Expressed Novel MicroRNAs as Potential Biomarkers in Dengue Virus Type 1 Infection

2021 ◽  
Vol 67 (02/2021) ◽  
Author(s):  
Juan Teng ◽  
Qingliang Wang ◽  
Xiaojie Li ◽  
Li Chen ◽  
Dayong Gu ◽  
...  
Keyword(s):  
Dengue Virus ◽  
Virus Type ◽  
Differentially Expressed ◽  
Potential Biomarkers

scholarly journals Dengue Virus Type 1 Nonstructural Glycoprotein NS1 Is Secreted from Mammalian Cells as a Soluble Hexamer in a Glycosylation-Dependent Fashion

1999 ◽  
Vol 73 (7) ◽  
pp. 6104-6110 ◽  
Author(s):  
Marie Flamand ◽  
Françoise Megret ◽  
Magali Mathieu ◽  
Jean Lepault ◽  
Félix A. Rey ◽  
...  
Keyword(s):  
Dengue Virus ◽  
Virus Type ◽  
Mammalian Cells ◽  
Culture Fluid ◽  
Vero Cells ◽  
Soluble Form ◽  
Complex Type ◽  
Infected Insect ◽  
Infected Cells

ABSTRACT Nonstructural glycoprotein NS1, specified by dengue virus type 1 (Den-1), is secreted from infected green monkey kidney (Vero) cells in a major soluble form characterized by biochemical and biophysical means as a unique hexameric species. This noncovalently bound oligomer is formed by three dimeric subunits and has a molecular mass of 310 kDa and a Stokes radius of 64.4 Å. During protein export, one of the two oligosaccharides of NS1 is processed into an endo-β-N-acetylglucosaminidase F-resistant complex-type sugar while the other remains of the polymannose type, protected in the dimeric subunit from the action of maturation enzymes. Complete processing of the complex-type sugar appears to be required for efficient release of soluble NS1 into the culture fluid of infected cells, as suggested by the repressive effects of the N-glycan processing inhibitors swainsonine and deoxymannojyrimicin. These results, together with observations related to the absence of secretion of NS1 from Den-infected insect cells, suggest that maturation and secretion of hexameric NS1 depend on the glycosylation status of the host cell.

Sign in / Sign up

Export Citation Format

Share Document