Atypical Kawasaki Disease after COVID-19 Vaccination: A New Form of Adverse Event Following Immunization

Kawasaki disease (KD) is a medium-vessel vasculitis that is typically presented during childhood; fewer than 100 cases of KD have been reported worldwide in adult patients who met the criteria according to the American College of Rheumatology. This study presents the case of an 18-year-old patient with no previous history of any disease, who presented atypical KD with liver and kidney dysfunction, with a good response to intravenous immunoglobulin therapy. The symptoms began 22 days after the application of the COVID-19 vaccine (nonreplicating viral vector Vaxzevria), and other conditions were ruled out. The term Adverse Events Following Immunization (AEFI)encompasses all the reactions that follow the application of any vaccine with no necessary causal relationship and can be due to the vaccine product, quality of the vaccine, immunization errors, or anxiety or just happen to be coincident events. These reactions should be reported so that clinicians can identify compatible cases and consider that the presentation of this disease, despite being atypical, can be manifested in adult patients. Likewise, case reports are an important basis for the pharmacovigilance of vaccines.

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Kawasaki Disease with Retropharyngeal Edema following a Blackfly Bite

Case Reports in Pediatrics ◽

10.1155/2014/296456 ◽

2014 ◽

Vol 2014 ◽

pp. 1-3 ◽

Cited By ~ 3

Author(s):

Toru Watanabe

Keyword(s):

Kawasaki Disease ◽

Subcutaneous Tissue ◽

Systemic Reaction ◽

Immunoglobulin Therapy ◽

Hypersensitive Reaction ◽

Retropharyngeal Abscess ◽

Cervical Lymph Nodes ◽

Intravenous Immunoglobulin Therapy ◽

Left Neck ◽

History Of

We describe a patient with Kawasaki disease (KD) and retropharyngeal edema following a blackfly bite. An 8-year-old boy was referred to our hospital because of a 3-day-history of fever and left neck swelling and redness after a blackfly bite. Computed tomography of the neck revealed left cervical lymph nodes swelling with edema, increased density of the adjacent subcutaneous tissue layer, and low density of the retropharyngeum. The patient was initially presumed to have cervical cellulitis, lymphadenitis, and retropharyngeal abscess. He was administered antibiotics intravenously, which did not improve his condition. The patient subsequently exhibited other signs of KD and was diagnosed with KD and retropharyngeal edema. Intravenous immunoglobulin therapy and oral flurbiprofen completely resolved the symptoms and signs. A blackfly bite sometimes incites a systemic reaction in humans due to a hypersensitive reaction to salivary secretions, which may have contributed to the development of KD in our patient.

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Crystalline-Like Keratopathy after Intravenous Immunoglobulin Therapy with Incomplete Kawasaki Disease: Case Report and Literature Review

Case Reports in Ophthalmological Medicine ◽

10.1155/2013/621952 ◽

2013 ◽

Vol 2013 ◽

pp. 1-4 ◽

Cited By ~ 1

Author(s):

Elif Erdem ◽

Emine Kocabas ◽

Hande Taylan Sekeroglu ◽

Özlem Özgür ◽

Meltem Yagmur ◽

...

Keyword(s):

Kawasaki Disease ◽

Intravenous Immunoglobulin ◽

Topical Steroid ◽

Immunoglobulin Therapy ◽

Incomplete Kawasaki Disease ◽

Intravenous Immunoglobulin Therapy ◽

Unexplained Fever ◽

Disease Case ◽

History Of ◽

Immunoglobulin Treatment

A 7-year-old girl had presented with high body temperature and joint pain which continued for 3 days. Because of the prolonged history of unexplained fever, rash, bilateral nonpurulent conjunctival injection, oropharyngeal erythema, strawberry tongue, and extreme of age, incomplete Kawasaki disease was considered and started on an intravenous immunoglobulin infusion. Six days after this treatment, patient was referred to eye clinic with decreased vision and photophobia. Visual acuity was reduced to 20/40 in both eyes. Slit-lamp examination revealed bilateral diffuse corneal punctate epitheliopathy and anterior stromal haze. Corneal epitheliopathy seemed like crystal deposits. One day after presentation, mild anterior uveitis was added to clinical picture. All ocular findings disappeared in one week with topical steroid and unpreserved artificial tear drops. We present a case who was diagnosed as incomplete Kawasaki disease along with bilateral diffuse crystalline-like keratopathy. We supposed that unusual ocular presentation may be associated with intravenous immunoglobulin treatment.

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Serum exosomal miR‑328, miR‑575, miR‑134 and miR‑671‑5p as potential biomarkers for the diagnosis of Kawasaki disease and the prediction of therapeutic outcomes of intravenous immunoglobulin therapy

Experimental and Therapeutic Medicine ◽

10.3892/etm.2018.6458 ◽

2018 ◽

Cited By ~ 4

Author(s):

Xiaofei Zhang ◽

Guangda Xin ◽

Dajun Sun

Keyword(s):

Kawasaki Disease ◽

Intravenous Immunoglobulin ◽

Immunoglobulin Therapy ◽

Intravenous Immunoglobulin Therapy ◽

Therapeutic Outcomes ◽

Potential Biomarkers

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Live attenuated vaccine efficacy six months after intravenous immunoglobulin therapy for Kawasaki disease

Vaccine ◽

10.1016/j.vaccine.2021.07.097 ◽

2021 ◽

Vol 39 (39) ◽

pp. 5680-5687

Author(s):

Yoshihiko Morikawa ◽

Hiroshi Sakakibara ◽

Takahisa Kimiya ◽

Toshimasa Obonai ◽

Masaru Miura

Keyword(s):

Kawasaki Disease ◽

Intravenous Immunoglobulin ◽

Vaccine Efficacy ◽

Immunoglobulin Therapy ◽

Intravenous Immunoglobulin Therapy ◽

Live Attenuated Vaccine ◽

Attenuated Vaccine

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Intravenous Immunoglobulin Therapy Induces Neutrophil Apoptosis in Kawasaki Disease

Clinical Immunology ◽

10.1006/clim.2002.5209 ◽

2002 ◽

Vol 103 (2) ◽

pp. 161-168 ◽

Cited By ~ 35

Author(s):

Hiroshi Tsujimoto ◽

Seiichiro Takeshita ◽

Keigo Nakatani ◽

Youichi Kawamura ◽

Tomoharu Tokutomi ◽

...

Keyword(s):

Kawasaki Disease ◽

Intravenous Immunoglobulin ◽

Immunoglobulin Therapy ◽

Neutrophil Apoptosis ◽

Intravenous Immunoglobulin Therapy

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Subsequent Development of Desmoid Tumor after a Resected Gastrointestinal Stromal Tumor

Case Reports in Pathology ◽

10.1155/2018/1082956 ◽

2018 ◽

Vol 2018 ◽

pp. 1-5

Author(s):

Areen Abdulelah Murshid ◽

Hatim Q. Al-Maghraby

Keyword(s):

Gastrointestinal Stromal Tumor ◽

Desmoid Tumor ◽

Case Reports ◽

Previous History ◽

Subsequent Development ◽

Stromal Tumor ◽

Desmoid Tumors ◽

Mesenchymal Tumors ◽

First Case ◽

History Of

Desmoid tumors (deep fibromatosis) of the mesentery are rare mesenchymal tumors. They are often misdiagnosed, especially with a previous history of resection for gastrointestinal stromal tumor (GIST). Immunohistochemistry can help differentiate between these two tumors. In this article, we present a case we had encountered: a Desmoid tumor developing in a patient with a history of GIST 3 years ago. It is the first case of GIST with subsequent development of Desmoid tumor to be reported in Saudi Arabia. We discuss the two entities of Desmoid tumor and GIST by comparing their definitions, clinical presentations, histological features, immunohistochemistry stains, molecular pathogenesis, prognosis, and treatment. We also discuss the relationship between GIST and the subsequent development of Desmoid tumors and compare our case with case reports in literature.

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