Different shaped samples of soaked leather in dichloromethane solution was pretreated by ultrasound technology, then the grease content in solution was measured by soxhlet extraction method. Samples before and after extraction were respectively made into histology slices in order to visually observe the situation of grease content. Results showed that compared with conventional extraction methods, extraction time was reduced to1/6~1/7 times and 50% solvent was saved by ultrasonic technology. Histology photos exhibited a cleaner extraction situation, which indicated that ultrasound technology behaved more efficient than conventional method in grease extraction.