scholarly journals Preliminary Analysis of PON3 rs2375003 Polymorphism in Pakistani Patients with Coronary Artery Disease

2019 ◽  
Vol 67 (3) ◽  
pp. 141-148
Author(s):  
Maryam Sameem ◽  
Muhammad Arshad
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Serum Lipid ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Lipid Levels ◽  
Pakistani Population ◽  
Serum Lipid Levels ◽  
Genotype Frequencies ◽  
Artery Disease

Coronary artery disease (CAD) is an inflammatory heart disease characterized by the narrowing of coronary arteries. Paraoxonase 3 (PON3) is a candidate gene for protection against CAD development as it reduces oxidative stress and lipid peroxidation. The present study aimed to explore the association of PON3 rs2375003 polymorphism with CAD development and serum lipid levels in the Pakistani population. Study subjects included 300 CAD patients and 300 age and sex matched healthy individuals. The genotyping of rs2375003 polymorphism was done using an allele specific polymerase chain reaction and serum lipid levels were determined. In this study, the genotype frequencies of rs2375003 polymorphismin in CAD patients were TT (2%), CT (8%), CC (90%) as compared to TT (3%), CT (6%), CC (91%) in the healthy subjects. No association was observed between rs2375003 polymorphism and CAD risk (p>0.05). The CT genotype of rs2375003 polymorphism marginally increased the risk for CAD development (OR: 1.36; 95% CI 0.72-2.56) by causing a marginal rise in total cholesterol, low density lipoprotein cholesterol and triglyceride levels, and a marginal drop in high density lipoprotein cholesterol levels. The CT genotype of rs2375003 polymorphism and altered lipid levels might act as potential risk factors in the etiology of CAD in the Pakistani population.

Non-fasting samples for estimation of serum lipid levels in patients with coronary artery disease

2014 ◽  
Vol 3 (3) ◽  
pp. 206
Author(s):  
P Srilakshmi ◽  
MF Gopinath ◽  
MVijaya Bhaskar ◽  
K Rambabu ◽  
GSrinivasa Reddy
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Serum Lipid ◽  
Lipid Levels ◽  
Serum Lipid Levels ◽  
Artery Disease

scholarly journals USF1 Contributes to High Serum Lipid Levels in Dutch FCHL Families and U.S. Whites With Coronary Artery Disease

2007 ◽  
Vol 27 (10) ◽  
pp. 2222-2227 ◽  
Author(s):  
Jenny C. Lee ◽  
Daphna Weissglas-Volkov ◽  
Mira Kyttälä ◽  
Janet S. Sinsheimer ◽  
Anne Jokiaho ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Serum Lipid ◽  
High Serum ◽  
Lipid Levels ◽  
Serum Lipid Levels ◽  
Artery Disease

scholarly journals Association between SLC44A4-NOTCH4 SNPs and serum lipid levels in the Chinese Han and Maonan ethnic groups

2020 ◽  
Vol 17 (1) ◽  
Author(s):  
Peng-Fei Zheng ◽  
Rui-Xing Yin ◽  
Yao-Zong Guan ◽  
Bi-Liu Wei ◽  
Chun-Xiao Liu ◽  
...  
Keyword(s):  
Ethnic Groups ◽  
Serum Lipid ◽  
Density Lipoprotein ◽  
Notch Receptor ◽  
Lipoprotein Cholesterol ◽  
Lipid Levels ◽  
Serum Lipid Levels ◽  
Genotype Frequencies ◽  
The Relationship ◽  
Lipid Parameters

Abstract Background The current research was to assess the relationship of the solute carrier family 44 member 4 (SLC44A4) rs577272, notch receptor 4 (NOTCH4) rs3134931 SNPs and serum lipid levels in the Han and Maonan ethnic groups. Methods The genetic makeup of the SLC44A4 rs577272 and NOTCH4 rs3134931 SNPs in 2467 unrelated subjects (Han, 1254; Maonan,1213) was obtained by using polymerase chain reaction and restriction fragment length polymorphism technique, combined with gel electrophoresis, and confirmed by direct sequencing. Results The genotype frequencies of SLC44A4 rs577272 and NOTCH4 rs3134931 SNPs were different between Han and Maonan populations (P < 0.05); respectively. The SLC44A4 rs577272 SNP was associated with total cholesterol (TC) and high-density lipoprotein cholesterol (HDL-C) levels in Maonan group. The NOTCH4 rs3134931 SNP was associated with triglyceride (TG) in Han; and TG and low-density lipoprotein cholesterol (LDL-C) levels in Maonan groups (P < 0.025–0.001). Stratified analysis according to gender showed that the SLC44A4 rs577272 SNP was associated with TC and HDL-C in Han and Maonan females; TC in Maonan males, meanwhile, the NOTCH4 rs3134931 SNP was associated with TG and HDL-C in Han males; TG in Han females; TG and LDL-C in Maonan males; and TG, HDL-C and LDL-C in Maonan females. Linkage disequilibrium analysis showed that the most common haplotype was rs577272G-rs3134931A (> 50%) in both Han and Maonan groups. The haplotype of rs577272G-rs3134931A was associated with TG and HDL-C in Han; and TC, TG and HDL-C in Maonan ethnic groups. Conclusions These results suggest that the relationship among SLC44A4 rs577272, NOTCH4 rs3134931 SNPs and serum lipid parameters may vary depending on the gender and/or ethnicity/race in some populations. Haplotypes could explain more changes in serum lipid parameters than any single SNP alone particularly for TC, TG and HDL-C.

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