Faculty Opinions recommendation of Peroxynitrite-induced neuronal apoptosis is mediated by intracellular zinc release and 12-lipoxygenase activation.

2005 ◽  
Author(s):  
Leah Keshet
Keyword(s):  
Neuronal Apoptosis ◽  
Intracellular Zinc ◽  
Zinc Release ◽  
12 Lipoxygenase

scholarly journals Intracellular Zinc Release, 12-Lipoxygenase Activation and MAPK Dependent Neuronal and Oligodendroglial Death

2007 ◽  
Vol 13 (7-8) ◽  
pp. 350-355 ◽  
Author(s):  
Yumin Zhang ◽  
Elias Aizenman ◽  
Donald B. DeFranco ◽  
Paul A. Rosenberg
Keyword(s):  
Intracellular Zinc ◽  
Zinc Release ◽  
12 Lipoxygenase

Silver ions induce oxidative stress and intracellular zinc release in human skin fibroblasts

2009 ◽  
Vol 47 (11) ◽  
pp. 1570-1577 ◽  
Author(s):  
Miriam M. Cortese-Krott ◽  
Meike Münchow ◽  
Elvis Pirev ◽  
Florian Heβner ◽  
Ahmed Bozkurt ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Human Skin ◽  
Silver Ions ◽  
Skin Fibroblasts ◽  
Human Skin Fibroblasts ◽  
Intracellular Zinc ◽  
Zinc Release

scholarly journals Involvement of IL-4-induced intracellular zinc release in microglial M2 phenotype

2018 ◽  
Vol WCP2018 (0) ◽  
pp. PO1-1-100
Author(s):  
Takaaki Aratake ◽  
Youichirou Higashi ◽  
Takahiro Shimizu ◽  
Shogo Shimizu ◽  
Yusuke Ueba ◽  
...  
Keyword(s):  
Intracellular Zinc ◽  
Zinc Release ◽  
M2 Phenotype

scholarly journals Kupyaphores are counter regulatory zinc homeostatic metallophores required for Mycobacterium tuberculosis colonization

2021 ◽  
Author(s):  
Kritee Mehdiratta ◽  
Shubham Singh ◽  
Sachin Sharma ◽  
Rashmi Bhosale ◽  
Rahul Choudhury ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Clinical Studies ◽  
Covalent Modification ◽  
Zinc Homeostasis ◽  
Macrophage Infection ◽  
Intracellular Zinc ◽  
Nutritional Deprivation ◽  
Zinc Release ◽  
Metabolic Imbalance ◽  
And Function

Abstract Tuberculosis (TB) patients suffer from progressive and debilitating loss of muscle mass and function, referred to as cachexia. Though a multifactorial condition, cachexia in cancer is promoted by systemic zinc redistribution and accumulation in muscles. Clinical studies with TB patients indeed show zinc dyshomeostasis. We therefore set out to understand mechanisms by which Mycobacterium tuberculosis (Mtb) govern zinc metallostasis at the host-pathogen interface. Here, we report a novel zinc metallophore from Mtb that restores zinc metabolic imbalance. These diisonitrile lipopeptides, named kupyaphores are transiently induced early-on during macrophage infection and also in infected mice lungs. Kupyaphores protects bacteria from host-mediated nutritional deprivation and intoxication. Kupyaphore Mtb mutant strain cannot mobilize zinc and shows reduced fitness in mice. Further, we characterize Mtb encoded isonitrile hydratase that could mediate intracellular zinc release through covalent modification of kupyaphores. Our studies could provide a molecular link between TB-induced altered zinc homeostasis and associated cachexia.

Depletion of Intracellular Zinc Induces Protein Synthesis-Dependent Neuronal Apoptosis in Mouse Cortical Culture

1998 ◽  
Vol 154 (1) ◽  
pp. 47-56 ◽  
Author(s):  
Young-Ho Ahn ◽  
Yang-Hee Kim ◽  
Seung-Hwan Hong ◽  
Jae-Young Koh
Keyword(s):  
Protein Synthesis ◽  
Neuronal Apoptosis ◽  
Intracellular Zinc ◽  
Cortical Culture
Sign in / Sign up

Export Citation Format

Share Document