Faculty Opinions recommendation of A role for CD103 in the retention of CD4+CD25+ Treg and control of Leishmania major infection.

2005 ◽  
Author(s):  
Phillip Scott
Keyword(s):  
Leishmania Major ◽  
Major Infection ◽  
And Control

scholarly journals Cutaneous Leishmaniasis (Leishmania major Infection) in Dutch Troops Deployed in Northern Afghanistan: Epidemiology, Clinical Aspects, and Treatment

2010 ◽  
Vol 83 (6) ◽  
pp. 1295-1300 ◽  
Author(s):  
Pieter-Paul van Thiel ◽  
Wendy F. van der Meide ◽  
Allard van der Sluis ◽  
Jimmy E. Zeegelaar ◽  
Aldert Bart ◽  
...  
Keyword(s):  
Cutaneous Leishmaniasis ◽  
Leishmania Major ◽  
Clinical Aspects ◽  
Major Infection

scholarly journals Role for CD4+ CD25+ Regulatory T Cells in Reactivation of Persistent Leishmaniasis and Control of Concomitant Immunity

2004 ◽  
Vol 200 (2) ◽  
pp. 201-210 ◽  
Author(s):  
Susana Mendez ◽  
Stacie K. Reckling ◽  
Ciriacco A. Piccirillo ◽  
David Sacks ◽  
Yasmine Belkaid
Keyword(s):  
Immune Responses ◽  
Leishmania Major ◽  
Parasite Clearance ◽  
Effector Memory ◽  
Memory Response ◽  
Secondary Challenge ◽  
Concomitant Immunity ◽  
Disease Reactivation ◽  
And Control ◽  
Parasite Leishmania

Reactivation of dormant infections causes an immense burden of morbidity and mortality in the world at large. Reactivation can occur as a result of immunosuppression, environmental insult, or aging; however, the cause of reactivation of such infections is often not clear. We have previously shown that persistence of the parasite Leishmania major is controlled by endogenous CD4+ CD25+ regulatory T (T reg) cells. In this report, we show that despite efficient parasite clearance at secondary sites of infection, Leishmania superinfection can cause disease reactivation at the primary site. Our results strongly suggest that T reg cells, whose numbers increase in sites of reactivation, are directly responsible for such reactivation. Depletion of CD25+ cells at the time of secondary challenge prevented disease reactivation at the site of persistent infection while strengthening the expression of immunity at the site of secondary challenge. Finally, transfer of T reg cells purified from infected mice into chronically infected mice was sufficient to trigger disease reactivation and prevent the expression of an effector memory response. Our results demonstrate that after persistence is achieved, an equilibrium between T reg cells and effector lymphocytes, which can be disturbed by superinfection, controls the efficiency of recall immune responses and disease reactivation.

scholarly journals Inhibition of caspase-8 activity promotes protective Th1- and Th2-mediated immunity to Leishmania major infection

2013 ◽  
Vol 95 (2) ◽  
pp. 347-355 ◽  
Author(s):  
Wânia F. Pereira-Manfro ◽  
Flávia L. Ribeiro-Gomes ◽  
Alessandra Almeida Filardy ◽  
Natália S. Vellozo ◽  
Landi V. C. Guillermo ◽  
...  
Keyword(s):  
Leishmania Major ◽  
Caspase 8 ◽  
Major Infection ◽  
Th1 And Th2

scholarly journals Deletion of the Aryl Hydrocarbon Receptor Enhances the Inflammatory Response to Leishmania major Infection

2011 ◽  
Vol 7 (9) ◽  
pp. 1220-1229 ◽  
Author(s):  
Guillermo Elizondo ◽  
Miriam Rodríguez-Sosa ◽  
Elizabet Estrada-Muñiz ◽  
Frank J. Gonzalez ◽  
Libia Vega
Keyword(s):  
Inflammatory Response ◽  
Aryl Hydrocarbon Receptor ◽  
Leishmania Major ◽  
Major Infection ◽  
Aryl Hydrocarbon

scholarly journals Histopathology of Leishmania major infection: revisiting L. major histopathology in the ear dermis infection model

2009 ◽  
Vol 104 (6) ◽  
pp. 918-922 ◽  
Author(s):  
Silvia Dantas Cangussú ◽  
Carolina Carvalho de Souza ◽  
Camila França Campos ◽  
Leda Quercia Vieira ◽  
Luís Carlos Crocco Afonso ◽  
...  
Keyword(s):  
Leishmania Major ◽  
Infection Model ◽  
Major Infection

scholarly journals Murine cathelicidin: as a host defensive response against Leishmania major infection

2020 ◽  
Vol 44 (3) ◽  
pp. 633-638 ◽  
Author(s):  
Arash Asadi ◽  
Amir Tavakoli Kareshk ◽  
Iraj Sharifi ◽  
Nima Firouzeh
Keyword(s):  
Leishmania Major ◽  
Defensive Response ◽  
Major Infection
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