Faculty Opinions recommendation of Induction of suppressor of cytokine signaling-1 by Toxoplasma gondii contributes to immune evasion in macrophages by blocking IFN-gamma signaling.

2006 ◽  
Author(s):  
Eric Denkers
Keyword(s):  
Toxoplasma Gondii ◽  
Immune Evasion ◽  
Cytokine Signaling ◽  
Suppressor Of Cytokine Signaling ◽  
Ifn Gamma

scholarly journals PD-1 /PD-L1 Adoptive Checkpoint Biosynthesis Separately Are Regulated By Gamma Common Which Regulate PD-1, Globin, and IFN-Gamma

2021 ◽  
pp. 1-9
Author(s):  
Ashraf Marzouk El Tantawi ◽  
Keyword(s):  
T Cells ◽  
Tyrosine Kinases ◽  
Adaptor Protein ◽  
Cytokine Signaling ◽  
Immune Functions ◽  
Suppressor Of Cytokine Signaling ◽  
Ifn Gamma ◽  
Helical Proteins

PD-1 /PD-L1 is adoptive checkpoint mechanism, where PD-1 is an adopting its PD-L1 ligand activities by presence of specific helical kinase proteins in its compositions: _gamma common chains,_LNK” lymphocyte adaptor protein, _or SH2B adaptor _protein “tyrosine kinases, and _”SOCS” suppressor of cytokine signaling, that specified for controlling PD-1 and PD-L1 bindings activity through temporary resting the PD-L1 and consequently T-cells activities then transform incoming signals to exogenous processes in favor the of proper immune functions, But the permanent inhibition of PD-1 /PD-L1 binding is due to breaking down or inhibition in one or more of the adaptors helical proteins (lymphocyte adaptor protein, or SH2B) with the presence of SOCS” suppressor of cytokine signaling that will increase stability of binding without adopting and without activities, but cells survival can still exist through presence of tyrosine kinases , interferon stimulate kinases ,and gamma common.

scholarly journals Cell invasion and strain dependent induction of suppressor of cytokine signaling-1 by Toxoplasma gondii

Immunobiology ◽  
2012 ◽  
Vol 217 (1) ◽  
pp. 28-36 ◽  
Author(s):  
Andrea Stutz ◽  
Henning Kessler ◽  
Mariel-Esther Kaschel ◽  
Markus Meissner ◽  
Alexander H. Dalpke
Keyword(s):  
Toxoplasma Gondii ◽  
Cell Invasion ◽  
Cytokine Signaling ◽  
Suppressor Of Cytokine Signaling ◽  
Strain Dependent

Die Aktivierung der MKK6/p38 Kaskade ist essentiell für die Stabilisierung der Suppressor of Cytokine Signaling 3 mRNA durch TNF-alpha

2006 ◽  
Vol 44 (01) ◽  
Author(s):  
C Ehlting ◽  
F Schaper ◽  
ED Brenndörfer ◽  
PC Heinrich ◽  
D Häussinger ◽  
...  
Keyword(s):  
Tnf Alpha ◽  
Cytokine Signaling ◽  
Suppressor Of Cytokine Signaling
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