Faculty Opinions recommendation of Chlamydia trachomatis enters a viable but non-cultivable (persistent) state within herpes simplex virus type 2 (HSV-2) co-infected host cells.

2006 ◽  
Author(s):  
Rino Rappuoli
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Chlamydia Trachomatis ◽  
Virus Type ◽  
Herpes Simplex Virus Type ◽  
Host Cells ◽  
Infected Host ◽  
Simplex Virus

Chlamydia trachomatis enters a viable but non-cultivable (persistent) state within herpes simplex virus type 2 (HSV-2) co-infected host cells

2006 ◽  
Vol 8 (1) ◽  
pp. 149-162 ◽  
Author(s):  
Srilekha Deka ◽  
Jennifer Vanover ◽  
Sophie Dessus-Babus ◽  
Judy Whittimore ◽  
Mary K. Howett ◽  
...  
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Chlamydia Trachomatis ◽  
Virus Type ◽  
Herpes Simplex Virus Type ◽  
Host Cells ◽  
Infected Host ◽  
Simplex Virus

Herpes simplex virus type 2 and Chlamydia trachomatis in adenocarcinoma of the uterine cervix

2007 ◽  
Vol 105 (1) ◽  
pp. 172-175 ◽  
Author(s):  
M ZEREU ◽  
C ZETTLER ◽  
E CAMBRUZZI ◽  
A ZELMANOWICZ
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Chlamydia Trachomatis ◽  
Virus Type ◽  
Herpes Simplex Virus Type ◽  
Uterine Cervix ◽  
Simplex Virus

Seroprevalences of herpes simplex virus type 2 and Chlamydia trachomatis in Turkey

2009 ◽  
Vol 280 (5) ◽  
pp. 739-743 ◽  
Author(s):  
Işıl Maral ◽  
Aydan Biri ◽  
Ümit Korucuoğlu ◽  
Coşkun Bakar ◽  
Meltem Çırak ◽  
...  
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Chlamydia Trachomatis ◽  
Virus Type ◽  
Herpes Simplex Virus Type ◽  
Simplex Virus

scholarly journals An early event in the herpes simplex virus type-2 replication cycle is sufficient to induce Chlamydia trachomatis persistence

2007 ◽  
Vol 9 (3) ◽  
pp. 725-737 ◽  
Author(s):  
Srilekha Deka ◽  
Jennifer Vanover ◽  
Jingru Sun ◽  
Jennifer Kintner ◽  
Judy Whittimore ◽  
...  
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Chlamydia Trachomatis ◽  
Virus Type ◽  
Herpes Simplex Virus Type ◽  
Replication Cycle ◽  
Early Event ◽  
Simplex Virus

scholarly journals Interaction of herpes simplex virus type 2 (HSV-2) glycoprotein D with the host cell surface is sufficient to induce Chlamydia trachomatis persistence

Microbiology ◽  
2010 ◽  
Vol 156 (5) ◽  
pp. 1294-1302 ◽  
Author(s):  
J. Vanover ◽  
J. Kintner ◽  
J. Whittimore ◽  
R. V. Schoborg
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Chlamydia Trachomatis ◽  
Cell Surface ◽  
Host Cell ◽  
Virus Type ◽  
Herpes Simplex Virus Type ◽  
Host Cell Surface ◽  
Simplex Virus

When presented with certain unfavourable environmental conditions, Chlamydia trachomatis reticulate bodies (RBs) enter into a viable, yet non-cultivable state called persistence. Previously, we established an in vitro C. trachomatis and herpes simplex virus type 2 (HSV-2) co-infection model. These data indicate that (i) viral co-infection stimulates chlamydial persistence, (ii) productive HSV replication is not required for persistence induction, and (iii) HSV-induced persistence is not mediated by any currently characterized anti-chlamydial pathway or persistence inducer. In this study we demonstrated that chlamydial infectivity, though initially suppressed, recovered within 44 h of co-infection with UV-inactivated HSV-2, demonstrating that HSV-induced persistence is reversible. Co-incubation of chemically fixed, HSV-2-infected inducer cells with viable, C. trachomatis-infected responder cells both suppressed production of infectious chlamydial progeny and stimulated formation of swollen, aberrantly shaped RBs. In addition, pre-incubation of viral particles with viral glycoprotein D (gD)-specific neutralizing antibody prevented co-infection-induced persistence. Finally, exposure of C. trachomatis-infected cells to a soluble, recombinant HSV-2 gD : Fc fusion protein decreased production of infectious EBs to a degree similar to that observed in co-infected cultures. Thus, we conclude that interaction of HSV gD with the host cell surface is sufficient to trigger a novel host anti-chlamydial response that restricts chlamydial development.

Vero Cells Co-Infected with Chlamydia trachomatis and Herpes Simplex Virus Type 2

1989 ◽  
Vol 16 (2) ◽  
pp. 74-78 ◽  
Author(s):  
RODERIC D. PONTEFRACT ◽  
CHEE-WAH NG ◽  
GILLES BERGERON
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Chlamydia Trachomatis ◽  
Virus Type ◽  
Herpes Simplex Virus Type ◽  
Vero Cells ◽  
Simplex Virus
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