Faculty Opinions recommendation of A replicated molecular genetic basis for subtyping antisocial behavior in children with attention-deficit/hyperactivity disorder.

2008 ◽  
Author(s):  
Luis Rohde
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Antisocial Behavior ◽  
Attention Deficit ◽  
Genetic Basis ◽  
Molecular Genetic ◽  
Hyperactivity Disorder ◽  
Molecular Genetic Basis

Identification of Attention-Deficit/Hyperactivity Disorder Pedigrees and Substance Use Disorder Pedigrees Through an ADHD Proband Sample

CNS Spectrums ◽  
1999 ◽  
Vol 4 (5) ◽  
pp. 55-58
Author(s):  
Amy Bauer ◽  
Ranga Ram ◽  
Kim M. Schindler ◽  
Michele T. Pato ◽  
Fabio Macciardi ◽  
...  
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Substance Use ◽  
Drug Use ◽  
Substance Use Disorder ◽  
Attention Deficit ◽  
Genetic Basis ◽  
Hyperactivity Disorder ◽  
Familial Cases ◽  
Genetic Risks ◽  
Drug And Alcohol

AbstractSubstance use disorder (SUD) pedigrees identified through an attention deficit/hyperactivity disorder (ADHD) proband may be helpful in teasing apart the genetic risks for both ADHD and SUD (ie, alcohol or drug use). Pedigrees segregating for both SUD and ADHD may represent a subset of both of these common disorders that share a related genetic basis. We determined the number of SUD and ADHD pedigrees in a sample of 175 ADHD probands. We found 52 ADHD pedigrees, indicating that at least 29.7% were familial cases. We also found 50 SUD pedigrees; 13 families contained both an alcohol and a drug pedigree, 35 families were alcohol-only pedigrees, and two families were drug-only pedigrees. The incidence of drug-only pedigrees is significantly higher (P<0.01) in families with familial ADHD. This was also true for families with both drug and alcohol pedigrees (P<0.01). The total number of SUD pedigrees and the families with alcohol-alone pedigrees were not significantly different in ADHD pedigrees compared with nonfamilial ADHD families.

Examining the Genetic Contribution to ADHD

2014 ◽  
Vol 16 (1) ◽  
pp. 20-28 ◽  
Author(s):  
Anthony Dillon ◽  
Rhonda G. Craven
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Effect Size ◽  
Attention Deficit ◽  
Genetic Basis ◽  
Treatment Options ◽  
Genetic Contribution ◽  
Hyperactivity Disorder ◽  
Biological Causation ◽  
Scientific Status

The scientific status of attention deficit hyperactivity disorder (ADHD) is highly controversial. Much of the controversy hinges on whether ADHD is a biological disorder. Advocates of biological causation often argue that it has a genetic basis. Etiology of ADHD has implications for treatment options, which is also a source of controversy. Given the ongoing interest in establishing the genetic basis of ADHD, this article critically examines the claims of a genetic basis to ADHD. We conclude that although genes may have a role to play in the expression of ADHD behaviors, available evidence suggests that the effect size of a genetic contribution is likely to be small.

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