Faculty Opinions recommendation of Bilateral oophorectomy before 50 years of age is significantly associated with the metabolic syndrome and Framingham risk score: a controlled, population-based study (HUNT-2).

2008 ◽  
Author(s):  
Matthew Allison
Keyword(s):  
Metabolic Syndrome ◽  
Risk Score ◽  
Framingham Risk Score ◽  
Population Based ◽  
Bilateral Oophorectomy ◽  
Population Based Study ◽  
The Metabolic Syndrome ◽  
Framingham Risk

The metabolic syndrome is amplified in hypothyroid rheumatoid arthritis patients: a cross-sectional study

2008 ◽  
Vol 69 (01) ◽  
pp. 39-42 ◽  
Author(s):  
H G Raterman ◽  
I C van Eijk ◽  
A E Voskuyl ◽  
M J L Peters ◽  
B A C Dijkmans ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Metabolic Syndrome ◽  
Cardiovascular Risk ◽  
Risk Score ◽  
Framingham Risk Score ◽  
Risk Profile ◽  
Cardiovascular Risk Profile ◽  
Prevalence Odds Ratio ◽  
The Metabolic Syndrome ◽  
Framingham Risk

Objectives:Rheumatoid arthritis (RA) patients are at increased risk of cardiovascular disease (CVD), which is even more pronounced in hypothyroid RA patients. An unfavourable cardiovascular risk profile conferred by a higher prevalence of the metabolic syndrome (MetS) and a higher Framingham risk score might explain this amplified cardiovascular morbidity. This study compared first, MetS (features) and second, the Framingham 10-year CVD risk in RA patients with hypothyroidism compared with euthyroid RA patients.Methods:RA patients participating in the CARRÉ investigation were divided into two groups: hypothyroid and euthyroid RA patients. MetS according to the National Cholesterol Education Program Third Adult Treatment Panel criteria and the Framingham risk score was compared between hypothyroid and non-hypothyroid CVD event-free RA patients.Results:In total, 257 RA patients were included: 236 with RA (91.8%) and 21 with hypothyroid RA (8.2%), respectively. The prevalence of the MetS was significantly higher in hypothyroid RA patients (43%) compared with RA patients (20%). Moreover, female hypothyroid RA patients had a higher Framingham risk score compared with euthyroid RA patients. With RA patients as the reference category, the age and gender-adjusted prevalence odds ratio for the MetS was 3.5 (95% CI 1.3 to 9.1) in hypothyroid RA.Conclusions:Hypothyroid RA patients, particularly female patients, have a more unfavourable cardiovascular risk profile, reflected by an increased prevalence of the MetS and higher Framingham score, than euthyroid RA patients, suggesting a greater need for cardiovascular risk management in these patients to prevent future CVD events.

scholarly journals Framingham Risk Score for Prediction of Cardiovascular Diseases: A Population-Based Study from Southern Europe

PLoS ONE ◽  
2013 ◽  
Vol 8 (9) ◽  
pp. e73529 ◽  
Author(s):  
Luis M. Artigao-Rodenas ◽  
Julio A. Carbayo-Herencia ◽  
Juan A. Divisón-Garrote ◽  
Vicente F. Gil-Guillén ◽  
Javier Massó-Orozco ◽  
...  
Keyword(s):  
Cardiovascular Diseases ◽  
Risk Score ◽  
Framingham Risk Score ◽  
Population Based ◽  
Southern Europe ◽  
Population Based Study ◽  
Framingham Risk

Abstract 3299: Association Of The Metabolic Syndrome, Diabetes And Framingham Risk Score With Coronary Artery Calcium

Circulation ◽  
2007 ◽  
Vol 116 (suppl_16) ◽  
Author(s):  
Uzoma N Ibebuogu ◽  
nathan D Wong ◽  
Jessica Ramirez ◽  
SongShou Mao ◽  
Fereshteh Hajsadeghi ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Risk Factor ◽  
Coronary Artery ◽  
Risk Score ◽  
Coronary Artery Calcium ◽  
Framingham Risk Score ◽  
Subclinical Atherosclerosis ◽  
The Metabolic Syndrome ◽  
Framingham Risk ◽  
Risk Factor Burden

INTRODUCTION: Coronary artery calcium (CAC) is a sensitive marker for the detection of subclinical coronary heart disease (CHD), and can be accurately quantified using cardiac computed tomography. Few studies have examined the relation between the metabolic syndrome (MetS), MetS risk factor burden, diabetes, and CAC. HYPOTHESIS: To examine the relation between MetS, as defined by the National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III), MetS risk factor burden, diabetes and CAC. METHODS: We studied 356 consecutive, asymptomatic men and women aged 58 ± 11 years who underwent CAC testing, 116 had MetS, 61 had diabetes, and the remainder had neither. MetS was defined according to the NCEP ATP III guidelines with ≥ 3 risk factors. The prevalence and odds of CAC among these groups were determined by multivariable logistic regression analysis. Receiver operating characteristic curves were used to determine if MetS or diabetes added to 10-year CHD estimated by the Framingham risk score (FRS) in predicting CAC. RESULTS: The prevalence of CAC >0 for those with diabetes, MetS and neither condition was 73%, 69% and 60% respectively, while the prevalence of CAC ≥ 100 for the 3 groups was 64%, 43% and 24% respectively. Risk factor-adjusted odds for the presence of CAC ≥ 100 were 2.26 (95% CI 1 to 4.4, p=0.0001) among those with MetS and 3.46 (95% CI 1.6 to 7.4, p=0.0001) among those with diabetes, versus neither condition. ROC analysis for CAC ≥ 100 showed an area under the curve of 0.61 (95% CI 0.54 – 0.68) for FRS, 0.72 (95% CI 0.61– 0.83) for diabetes, 0.67 (95% CI 0.56 – 0.77) for the metabolic syndrome, 0.78 (95% CI 0.7– 0.85) when the MetS is added to the FRS (p<0.0001 compared to FRS alone), and 0.90 (95% CI 0.85– 0.95) when diabetes is added to the FRS (p<0.0001 compared to FRS alone). The CAC score showed a trend towards a progressive increase across the metabolic score ranging from 0 to 5 (p=0.0001). CONCLUSIONS: Those with MetS or diabetes have an increased likelihood of subclinical atherosclerosis (measured by CAC) compared to those with neither condition, and they also add to prediction of CAC over FRS, suggesting the importance of these factors in clinical assessment of CHD risk.

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