Faculty Opinions recommendation of Oral calcitriol for the treatment of persistent proteinuria in immunoglobulin A nephropathy: an uncontrolled trial.

Abstract Immunoglobulin A nephropathy (IgAN) was defined as a mesangiopathic disease, since the primary site of deposition of IgA immune material is the mesangium, and proliferation of mesangial cells and matrix excess deposition are the first histopathologic lesions. However, the relentless silent progression of IgAN is mostly due to the development of persistent proteinuria, and recent studies indicate that a major role is played by previous damage of function and anatomy of podocytes. In IgAN, the podocytopathic changes are the consequence of initial alterations in the mesangial area with accumulation of IgA containing immune material. Podocytes are therefore affected by interactions of messages originally driven from the mesangium. After continuous insult, podocytes detach from the glomerular basement membrane. This podocytopathy favours not only the development of glomerular focal and segmental sclerosis, but also the progressive renal function loss. It is still debated whether these lesions can be prevented or cured by corticosteroid/immunosuppressive treatment. We aimed to review recent data on the mechanisms implicated in the podocytopathy present in IgAN, showing new molecular risk factors for progression of this disease. Moreover, these observations may indicate that the target for new drugs is not only focused on decreasing the activity of mesangial cells and inflammatory reactions in IgAN, but also on improving podocyte function and survival.

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Risk factor for persistent proteinuria in adulthood after clinical remission in Japanese children with immunoglobulin A nephropathy: impact of tonsillectomy combined with intravenous pulse methylprednisolone

Clinical and Experimental Nephrology ◽

10.1007/s10157-020-01877-w ◽

2020 ◽

Vol 24 (8) ◽

pp. 734-735

Author(s):

Shuichiro Fujinaga ◽

Chisato Umeda

Keyword(s):

Risk Factor ◽

Clinical Remission ◽

Immunoglobulin A ◽

Immunoglobulin A Nephropathy ◽

Japanese Children ◽

Pulse Methylprednisolone ◽

Persistent Proteinuria

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Immunoglobulin A nephropathy

Treatment of Primary Glomerulonephritis ◽

10.1093/med/9780199552887.003.0008 ◽

2009 ◽

pp. 313-374 ◽

Cited By ~ 5

Author(s):

Richard J. Glassock ◽

Grace Lee

Keyword(s):

Immunoglobulin A ◽

Senior Author ◽

Glomerular Disease ◽

Similar Distribution ◽

Variable Degree ◽

Immunoglobulin A Nephropathy ◽

Persistent Proteinuria ◽

Primary Glomerular Disease ◽

Stage Renal Disease ◽

End Stage

The term immunoglobulin A nephropathy (IgA nephropathy or IgA N) refers to a primary glomerular disease characterized by the dominant or co-dominant, diffuse, and generalized mesangial deposition of IgA, often accompanied by deposition of IgG and the C3 component of complement in a similar distribution (Donadio and Grande, 2004; Barratt and Feehally, 2005; Tomino, 2007; Glassock, 2008; Lai, 2008). In the past, it has also been referred to as Berger's disease, to signify the senior author of the original publication describing the disorder that first appeared more than 4 decades ago in September of 1968 (Berger and Hinglais, 1968). IgA N is most likely the commonest primary glomerular disease in the developed world (D’Amico, 1987). The disease is characterized principally by episodic glomerular hematuria often with persistent proteinuria of a variable degree. It usually runs an indolent course, but may lead to end-stage renal disease (ESRD) in about 30–50% of cases after 25 years or more of follow-up.

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Plasma CXCL16 May Predict Renal Inflammation and the Progression of Immunoglobulin a Nephropathy

SSRN Electronic Journal ◽

10.2139/ssrn.3424178 ◽

2019 ◽

Author(s):

Ran Luo ◽

Yi-Chun Chen ◽

Dan Chang ◽

Ting-Ting Liu ◽

Yue-Qiang Li ◽

...

Keyword(s):

Immunoglobulin A ◽

Immunoglobulin A Nephropathy ◽

Renal Inflammation

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Immunostaining of galactose-deficient IgA1 by KM55 is not specific for immunoglobulin A nephropathy

Clinical Immunology ◽

10.1016/j.clim.2020.108483 ◽

2020 ◽

Vol 217 ◽

pp. 108483 ◽

Cited By ~ 1

Author(s):

Lu Zhao ◽

Liang Peng ◽

Danyi Yang ◽

Shi Chen ◽

Zhixin Lan ◽

...

Keyword(s):

Immunoglobulin A ◽

Immunoglobulin A Nephropathy

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Non-visible haematuria in a military setting

Journal of The Royal Naval Medical Service ◽

10.1136/jrnms-104-177 ◽

2018 ◽

Vol 104 (3) ◽

pp. 177-182

Author(s):

D O’Brien ◽

K Houlberg

Keyword(s):

Basement Membrane ◽

Immunoglobulin A ◽

Armed Forces ◽

Common Finding ◽

Immunoglobulin A Nephropathy ◽

Hereditary Nephritis ◽

Military Recruits ◽

Thin Basement Membrane Disease ◽

Medical Examinations

AbstractAsymptomatic non-visible haematuria is a common finding at routine military medical examinations. This article briefly reviews the possible causes, which include malignancy, structural causes, exertion haematuria, hereditary nephritis, thin basement membrane disease (TBMD), immunoglobulin A nephropathy (IgAN), tuberculosis (TB) and schistosomiasis. This paper discusses how these conditions may affect potential military recruits as well as currently serving members of the Armed Forces, and offers a general approach to the management of a patient with non-visible haematuria.

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