Plasma CXCL16 May Predict Renal Inflammation and the Progression of Immunoglobulin a Nephropathy

2019 ◽  
Author(s):  
Ran Luo ◽  
Yi-Chun Chen ◽  
Dan Chang ◽  
Ting-Ting Liu ◽  
Yue-Qiang Li ◽  
...  
Keyword(s):  
Immunoglobulin A ◽  
Immunoglobulin A Nephropathy ◽  
Renal Inflammation

Immunostaining of galactose-deficient IgA1 by KM55 is not specific for immunoglobulin A nephropathy

2020 ◽  
Vol 217 ◽  
pp. 108483 ◽  
Author(s):  
Lu Zhao ◽  
Liang Peng ◽  
Danyi Yang ◽  
Shi Chen ◽  
Zhixin Lan ◽  
...  
Keyword(s):  
Immunoglobulin A ◽  
Immunoglobulin A Nephropathy

Non-visible haematuria in a military setting

2018 ◽  
Vol 104 (3) ◽  
pp. 177-182
Author(s):  
D O’Brien ◽  
K Houlberg
Keyword(s):  
Basement Membrane ◽  
Immunoglobulin A ◽  
Armed Forces ◽  
Common Finding ◽  
Immunoglobulin A Nephropathy ◽  
Hereditary Nephritis ◽  
Military Recruits ◽  
Thin Basement Membrane Disease ◽  
Medical Examinations

AbstractAsymptomatic non-visible haematuria is a common finding at routine military medical examinations. This article briefly reviews the possible causes, which include malignancy, structural causes, exertion haematuria, hereditary nephritis, thin basement membrane disease (TBMD), immunoglobulin A nephropathy (IgAN), tuberculosis (TB) and schistosomiasis. This paper discusses how these conditions may affect potential military recruits as well as currently serving members of the Armed Forces, and offers a general approach to the management of a patient with non-visible haematuria.

Immunoglobulin A Nephropathy in Blacks and Homozygosity for the Genetic Marker A2m

1986 ◽  
Vol 104 (2) ◽  
pp. 287 ◽  
Author(s):  
KOTRESHA NEELAKANTAPPA
Keyword(s):  
Genetic Marker ◽  
Immunoglobulin A ◽  
Immunoglobulin A Nephropathy

Podocytopathy in the mesangial proliferative immunoglobulin A nephropathy: new insights into the mechanisms of damage and progression

2019 ◽  
Vol 34 (8) ◽  
pp. 1280-1285 ◽  
Author(s):  
Hernán Trimarchi ◽  
Rosanna Coppo
Keyword(s):  
Mesangial Cells ◽  
Immunosuppressive Treatment ◽  
Immunoglobulin A ◽  
Primary Site ◽  
New Drugs ◽  
Immunoglobulin A Nephropathy ◽  
Inflammatory Reactions ◽  
Persistent Proteinuria ◽  
Mesangial Area ◽  
Function Loss

Abstract Immunoglobulin A nephropathy (IgAN) was defined as a mesangiopathic disease, since the primary site of deposition of IgA immune material is the mesangium, and proliferation of mesangial cells and matrix excess deposition are the first histopathologic lesions. However, the relentless silent progression of IgAN is mostly due to the development of persistent proteinuria, and recent studies indicate that a major role is played by previous damage of function and anatomy of podocytes. In IgAN, the podocytopathic changes are the consequence of initial alterations in the mesangial area with accumulation of IgA containing immune material. Podocytes are therefore affected by interactions of messages originally driven from the mesangium. After continuous insult, podocytes detach from the glomerular basement membrane. This podocytopathy favours not only the development of glomerular focal and segmental sclerosis, but also the progressive renal function loss. It is still debated whether these lesions can be prevented or cured by corticosteroid/immunosuppressive treatment. We aimed to review recent data on the mechanisms implicated in the podocytopathy present in IgAN, showing new molecular risk factors for progression of this disease. Moreover, these observations may indicate that the target for new drugs is not only focused on decreasing the activity of mesangial cells and inflammatory reactions in IgAN, but also on improving podocyte function and survival.

Brief Communication: Immunoglobulin A1 protease: A new therapeutic candidate for immunoglobulin A nephropathy

Nephrology ◽  
2010 ◽  
Vol 15 (5) ◽  
pp. 584-586 ◽  
Author(s):  
LIN-SHEN XIE ◽  
JUN HUANG ◽  
WEI QIN ◽  
JUN-MING FAN
Keyword(s):  
Immunoglobulin A ◽  
Immunoglobulin A Nephropathy

Absence of Mesangial C1q Deposition Is Associated with Resolution of Proteinuria and Hematuria after Tonsillectomy Plus Steroid Pulse Therapy for Immunoglobulin A Nephropathy

Nephron ◽  
2015 ◽  
Vol 130 (1) ◽  
pp. 1-7 ◽  
Author(s):  
Hiroki Nishiwaki ◽  
Takeshi Hasegawa ◽  
Yoshikuni Nagayama ◽  
Nobuharu Kaneshima ◽  
Mamiko Takayasu ◽  
...  
Keyword(s):  
Immunoglobulin A ◽  
Pulse Therapy ◽  
Steroid Pulse Therapy ◽  
Immunoglobulin A Nephropathy ◽  
Steroid Pulse

Clinicopathological characteristics of primary immunoglobulin A nephropathy with immunoglobulin M deposition

2021 ◽  
Author(s):  
Han Ouyang ◽  
Jian Wen ◽  
Kai Song ◽  
Huaying Shen
Keyword(s):  
Immunoglobulin A ◽  
Clinicopathological Characteristics ◽  
Immunoglobulin M ◽  
Endothelial Cell Proliferation ◽  
Negative Group ◽  
Immunoglobulin A Nephropathy ◽  
Positive Group ◽  
Renal Tubular ◽  
The Relationship ◽  
Ig G

IntroductionImmunoglobulin (Ig) G deposition in patients with IgA nephro­pathy (IgAN) often indicates poor prognosis, but the relationship between IgM deposition and the clinicopathology of IgAN remains controversial. The purpose of this study is to further understand the relationship between IgM deposition and IgAN, so as to provide a basis for clinical evaluation and treatment.Material and methodsWe included a total of 839 IgAN patients from the nephropathy departments of 2 hospitals; there were 162 IgM-positive patients and 677 IgM-negative patients. Clinical and pathological data were retrospectively analysed. In addition, a multifaceted comparison was made between the IgM-positive group and the IgM-negative group.ResultsThe serum albumin and IgG levels of the IgM-positive group were lower than those of the IgM-negative group, and the levels of low-density lipo­protein, 24 h proteinuria, and IgM were higher than those of the IgM-nega­tive group. The proportion of endothelial cell proliferation (E1), segmental sclerosis or adhesion (S1), and renal tubular interstitial score in the IgM-posi­tive group were all higher than those in the IgM-negative group. Immunofluo­rescence results showed that the proportion of IgM-positive combination and IgG and C1q deposition was higher than that in the IgM-negative group.ConclusionsImmunoglobulin A nephropathy patients with IgM deposition have relatively poor clinical biochemical indicators, and the degree of renal pathological damage is also relatively serious.

Coagulation Potentials in Pediatric Patients with Immunoglobulin A Nephropathy

2021 ◽  
Author(s):  
Takashi Omae ◽  
Tomoaki Ishikawa ◽  
Yuto Nakajima ◽  
Keiji Nogami
Keyword(s):  
Pediatric Patients ◽  
Immunoglobulin A ◽  
Immunoglobulin A Nephropathy
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