Faculty Opinions recommendation of Seropositivity for human papillomavirus and incidence of subsequent squamous cell and basal cell carcinomas of the skin in patients with a previous nonmelanoma skin cancer.

2011 ◽  
Author(s):  
J Andrew Carlson
Keyword(s):  
Human Papillomavirus ◽  
Skin Cancer ◽  
Squamous Cell ◽  
Basal Cell ◽  
Nonmelanoma Skin Cancer ◽  
Basal Cell Carcinomas

Rarity of Human Papillomavirus in Nonmelanoma Skin Cancer among Immunocompetent Patients

1997 ◽  
Vol 2 (1) ◽  
pp. 16-19 ◽  
Author(s):  
M.R. Karagas ◽  
S.K. Spencer ◽  
Martin A. Weinstock ◽  
J. Kuypers ◽  
M. Koff ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
Skin Cancer ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Basal Cell ◽  
Dna Amplification ◽  
Nonmelanoma Skin Cancer ◽  
Hpv Dna ◽  
Two Samples ◽  
Immunocompetent Patients

Background: The role of human papillomavirus (HPV) in nonmelanoma skin cancer (NMSC) among immunocompentent individuals is not well understood. Objective: We tested for the presence of HPV DNA in NMSC of immunocompetent patients from New England. Methods: Biopsies taken from 59 patients were reviewed histopathologically. A segment of the biopsy and scrapings from a site remote from the skin lesion were analyzed for HPV using a standardized polymerase chain reaction (PCR) DNA amplification assay. Results: Of 55 evaluable samples, 21 were histologically confirmed squamous cell carcinomas (SCC), 25 were basal cell carcinomas (BCC), and nine had other diagnoses. Two samples were HPV-positive (3.6%): a basal cell carcinoma of the forehead and a squamous cell carcinoma of the thumbnail bed. Type analysis of these samples revealed HPV 16 from both lesions. Conclusion: The HPV DNA is not commonly detected in NMSCs of immunocompetent patients using standard laboratory techniques. It is possible, however, that a wider range of HPV types could be detected using more sensitive assays; this warrants further investigation.

scholarly journals Epidemiology of basal cell carcinomas and squamous cell carcinomas in a Department of Dermatology: a 5 year review

2012 ◽  
Vol 87 (2) ◽  
pp. 212-219 ◽  
Author(s):  
Pedro Andrade ◽  
Maria Manuel Brites ◽  
Ricardo Vieira ◽  
Angelina Mariano ◽  
José Pedro Reis ◽  
...  
Keyword(s):  
Skin Cancer ◽  
Squamous Cell ◽  
Basal Cell ◽  
Skin Neoplasms ◽  
Squamous Cell Carcinomas ◽  
Exposed Skin ◽  
Non Melanoma Skin Cancer ◽  
Basal Cell Carcinomas ◽  
Malignant Skin ◽  
Melanoma Skin

BACKGROUND: Non-melanoma skin cancer, a common designation for both basal cell carcinomas and squamous cell carcinomas, is the most frequent malignant skin neoplasm. OBJECTIVE: Epidemiologic characterization of the population with Non-melanoma skin cancer. METHODS: Retrospective analysis of all patients diagnosed with Non-melanoma skin cancer based on histopathologic analysis of all incisional or excisional skin biopsies performed between 2004 and 2008 in a Department of Dermatology. RESULTS: A total of 3075 Non-melanoma skin cancers were identified, representing 88% of all malignant skin neoplasms (n=3493) diagnosed in the same period. Of those, 68,3% were basal cell carcinomas. Most Non-melanoma skin cancer patients were female and over 60 years old. Of all Non-melanoma skin cancer, 81,7% (n=1443) were located in sun-exposed skin, and represented 95,1% of malignant skin neoplasms in sun-exposed skin. Non-melanoma skin cancer was the most frequent malignant skin neoplasm in most topographic locations, except for abdomen and pelvis - over 95% of all malignant skin neoplasms in the face, neck and scalp were Non-melanoma skin cancer. Basal cell carcinomas were clearly predominant in all locations, except in upper and lower limbs, lower lip and genitals, where squamous cell carcinomas represented respectively 77,7%, 77,4%, 94,7% and 95,3% of the Non-melanoma skin cancers. CONCLUSION: Being the most common skin cancer, Non-melanoma skin cancer should be under constant surveillance, in order to monitor its epidemiologic dynamics, the efficiency of preventive measures and the adaptation of the healthcare resources.

scholarly journals Human Papillomavirus Infection and Incidence of Squamous Cell and Basal Cell Carcinomas of the Skin

2006 ◽  
Vol 98 (6) ◽  
pp. 389-395 ◽  
Author(s):  
Margaret R. Karagas ◽  
Heather H. Nelson ◽  
Peter Sehr ◽  
Tim Waterboer ◽  
Therese A. Stukel ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
Squamous Cell ◽  
Basal Cell ◽  
Human Papillomavirus Infection ◽  
Papillomavirus Infection ◽  
Basal Cell Carcinomas

scholarly journals Nonmelanoma skin cancer in the population of the city of Belgrade in the period 1999-2011

2015 ◽  
Vol 143 (5-6) ◽  
pp. 290-295 ◽  
Author(s):  
Goran Videnovic ◽  
Dragan Miljus ◽  
Danijela Ilic ◽  
Dragan Krasic ◽  
Snezana Zivkovic
Keyword(s):  
Skin Cancer ◽  
Incidence Rate ◽  
Squamous Cell ◽  
Basal Cell ◽  
Nonmelanoma Skin Cancer ◽  
Skin Carcinoma ◽  
Skin Cancers ◽  
Nonmelanoma Skin Cancers ◽  
The City ◽  
Squamous Cell Skin Carcinoma

Introduction. Nonmelanoma skin cancers in the literature are mainly related to basal cell and squamous cell skin carcinoma. Objective. The aim of the study was to determine the trend in the incidence of histological types of nonmelanoma skin cancers in the population of the city of Belgrade from 1999 to 2011. Methods. From the Serbian National Cancer Registry we extracted all recorded cases of skin cancer in Belgrade from January 1st 1999 to December 31st 2011. Incidence rates were standardized by the method of direct standardization with the world population as the standard population. Trends and annual percentage change (APC) of incidence rate were calculated by performing joinpoint regression analyses. Results. Incidence rate of nonmelanoma skin cancer showed significantly increasing trend between 1999 and 2006 with APC of 8.6% (95% CI: 5.6-11.7), basal cell carcinoma increased with APC of 8.4% (95% CI: 5.2-11.6) and squamous cell skin carcinoma with APC of 9.33% (95% CI: 5.7-13.1). The incidence increased with age for both men and women, especially after the age of 60. Conclusion. Our results showed a continuously increasing incidence trend of both basal cell and squamous cell skin carcinomas in the population of the city of Belgrade between 1999 and 2011. Adequate primary and secondary prevention would certainly be successful in reducing this type of cancer in the future.

Somatic Mutations in TP53 Gene in Colombian Patients With Non-melanoma Skin Cancer

2022 ◽  
Vol 2 (1) ◽  
pp. 107-114
Author(s):  
LUZ DARY GUTIÉRREZ-CASTAÑEDA ◽  
JOHN NOVA ◽  
MARÍA IRENE CEREZO-CORTÉS
Keyword(s):  
Skin Cancer ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Basal Cell ◽  
Somatic Mutations ◽  
Tp53 Gene ◽  
Non Melanoma Skin Cancer ◽  
Basal Cell Carcinomas ◽  
Frequent Mutations ◽  
Melanoma Skin

Background/Aim: Non-melanoma skin cancer is the most common cancer in the world. Somatic mutations in the TP53 gene are associated with the development of this cancer. To describe mutations in exons 5-8 of the TP53 gene in a sample of Colombian patients with non-melanoma skin cancer. Materials and Methods: One hundred and fifteen patients with non-melanoma skin cancer were included. Exons 5-8 were amplified and analyzed by PCR-High Resolution Melting and Sanger sequencing. Results: Fifty-seven patients with basal cell carcinomas and 58 with squamous cell carcinomas were studied. 16% of patients with basal cell carcinoma and 26% of patients with squamous cell carcinoma had mutations in the TP53 gene. The most frequent mutations were substitutions, while three patients had deletions. The most frequent mutation was p.R158G. Conclusion: The analysis showed that Colombian individuals with non-melanoma skin cancer have genetic TP53 variants different from those reported as recurrent for this disease.

scholarly journals Margin Status in Shave Biopsies of Nonmelanoma Skin Cancers: Is It Worth Reporting?

2016 ◽  
Vol 140 (7) ◽  
pp. 678-681 ◽  
Author(s):  
Alicia M. Schnebelen ◽  
Jerad M. Gardner ◽  
Sara C. Shalin
Keyword(s):  
Skin Cancer ◽  
Squamous Cell ◽  
Basal Cell ◽  
Positive Margin ◽  
Margin Status ◽  
Positive Margins ◽  
Reporting Practices ◽  
Skin Cancers ◽  
Basal Cell Carcinomas ◽  
Nonmelanoma Skin Cancers

Context.—The practice of reporting margin status in biopsies is relatively unique to biopsies of the skin and highly variable among pathologists. Objective.—To address the accuracy of margin evaluation in shave biopsies of nonmelanoma skin cancers. Design.—We collected shave biopsies of squamous and basal cell carcinomas that appeared to have uninvolved margins on routine sign out. We obtained deeper levels on corresponding tissue blocks until blocks were exhausted and examined them for tumor at biopsy margins. Results.—Forty-seven consecutive cases were collected, including 20 squamous cell (43%) and 27 basal cell (57%) carcinomas. Eleven of 47 cases (23%) with negative margins at initial diagnosis demonstrated positive margins upon deeper-level examination. Margins of 8 of 27 basal cell carcinomas (30%) and 3 of 20 squamous cell carcinomas (15%) were erroneously classified as “negative” on routine examination. Conclusions.—No guidelines exist regarding the reporting of margins in nonmelanoma skin cancer biopsies, and reporting practices vary extensively among pathologists. We found that nearly one-quarter of positive margins in shave biopsies for cutaneous carcinomas are missed on standard histologic examination. Moreover, reporting of a positive margin may also be misleading if the clinician has definitively treated the skin cancer at the time of biopsy. For these reasons, and as routine exhaustion of all tissue blocks is impractical, the decision to include or exclude a comment regarding the margin status should be given conscious consideration, accounting for the clinical intent of the biopsy and any known information regarding postbiopsy treatment.

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