Faculty Opinions recommendation of Transgenerational epigenetic inheritance of longevity in Caenorhabditis elegans.

2012 ◽  
Author(s):  
Ferdinando Boero
Keyword(s):  
Caenorhabditis Elegans ◽  
Epigenetic Inheritance ◽  
Transgenerational Epigenetic Inheritance

scholarly journals Multigenerational Regulation of the Caenorhabditis elegans Chromatin Landscape by Germline Small RNAs

2019 ◽  
Vol 53 (1) ◽  
pp. 289-311 ◽  
Author(s):  
Natasha E. Weiser ◽  
John K. Kim
Keyword(s):  
Gene Expression ◽  
Caenorhabditis Elegans ◽  
Small Rnas ◽  
Model Organism ◽  
Epigenetic Inheritance ◽  
Small Interfering Rnas ◽  
Transgenerational Epigenetic Inheritance ◽  
C Elegans ◽  
Small Noncoding Rnas ◽  
Rna Pathways

In animals, small noncoding RNAs that are expressed in the germline and transmitted to progeny control gene expression to promote fertility. Germline-expressed small RNAs, including endogenous small interfering RNAs (endo-siRNAs) and Piwi-interacting RNAs (piRNAs), drive the repression of deleterious transcripts such as transposons, repetitive elements, and pseudogenes. Recent studies have highlighted an important role for small RNAs in transgenerational epigenetic inheritance via regulation of heritable chromatin marks; therefore, small RNAs are thought to convey an epigenetic memory of genomic self and nonself elements. Small RNA pathways are highly conserved in metazoans and have been best described for the model organism Caenorhabditis elegans. In this review, we describe the biogenesis, regulation, and function of C. elegans endo-siRNAs and piRNAs, along with recent insights into how these distinct pathways are integrated to collectively regulate germline gene expression, transgenerational epigenetic inheritance, and ultimately, animal fertility.

scholarly journals Transgenerational epigenetic inheritance of longevity in Caenorhabditis elegans

Nature ◽  
2011 ◽  
Vol 479 (7373) ◽  
pp. 365-371 ◽  
Author(s):  
Eric L. Greer ◽  
Travis J. Maures ◽  
Duygu Ucar ◽  
Anna G. Hauswirth ◽  
Elena Mancini ◽  
...  
Keyword(s):  
Caenorhabditis Elegans ◽  
Epigenetic Inheritance ◽  
Transgenerational Epigenetic Inheritance

How do histone modifications contribute to transgenerational epigenetic inheritance in C. elegans?

2020 ◽  
Vol 48 (3) ◽  
pp. 1019-1034 ◽  
Author(s):  
Rachel M. Woodhouse ◽  
Alyson Ashe
Keyword(s):  
Histone Modifications ◽  
Molecular Mechanisms ◽  
Epigenetic Inheritance ◽  
Nematode Caenorhabditis Elegans ◽  
Histone Methyltransferases ◽  
Transgenerational Epigenetic Inheritance ◽  
C Elegans ◽  
Recent Developments ◽  
Gene Regulatory

Gene regulatory information can be inherited between generations in a phenomenon termed transgenerational epigenetic inheritance (TEI). While examples of TEI in many animals accumulate, the nematode Caenorhabditis elegans has proven particularly useful in investigating the underlying molecular mechanisms of this phenomenon. In C. elegans and other animals, the modification of histone proteins has emerged as a potential carrier and effector of transgenerational epigenetic information. In this review, we explore the contribution of histone modifications to TEI in C. elegans. We describe the role of repressive histone marks, histone methyltransferases, and associated chromatin factors in heritable gene silencing, and discuss recent developments and unanswered questions in how these factors integrate with other known TEI mechanisms. We also review the transgenerational effects of the manipulation of histone modifications on germline health and longevity.

scholarly journals Chromatin Modifiers SET-25 and SET-32 Are Required for Establishment but Not Long-Term Maintenance of Transgenerational Epigenetic Inheritance

Cell Reports ◽  
2018 ◽  
Vol 25 (8) ◽  
pp. 2259-2272.e5 ◽  
Author(s):  
Rachel M. Woodhouse ◽  
Gabriele Buchmann ◽  
Matthew Hoe ◽  
Dylan J. Harney ◽  
Jason K.K. Low ◽  
...  
Keyword(s):  
Epigenetic Inheritance ◽  
Transgenerational Epigenetic Inheritance ◽  
Term Maintenance ◽  
Chromatin Modifiers

scholarly journals Mutator Foci Are Regulated by Developmental Stage, RNA, and the Germline Cell Cycle in Caenorhabditis elegans

2020 ◽  
Vol 10 (10) ◽  
pp. 3719-3728 ◽  
Author(s):  
Celja J. Uebel ◽  
Dana Agbede ◽  
Dylan C. Wallis ◽  
Carolyn M. Phillips
Keyword(s):  
Cell Cycle ◽  
Caenorhabditis Elegans ◽  
Epigenetic Inheritance ◽  
Germline Cell ◽  
Late Pachytene ◽  
Larval Stages ◽  
Transcriptional Inhibition ◽  
Male Germline ◽  
Early Embryos ◽  
Adult Hermaphrodite

RNA interference is a crucial gene regulatory mechanism in Caenorhabditis elegans. Phase-separated perinuclear germline compartments called Mutator foci are a key element of RNAi, ensuring robust gene silencing and transgenerational epigenetic inheritance. Despite their importance, Mutator foci regulation is not well understood, and observations of Mutator foci have been largely limited to adult hermaphrodite germlines. Here we reveal that punctate Mutator foci arise in the progenitor germ cells of early embryos and persist throughout all larval stages. They are additionally present throughout the male germline and in the cytoplasm of post-meiotic spermatids, suggestive of a role in paternal epigenetic inheritance. In the adult germline, transcriptional inhibition results in a pachytene-specific loss of Mutator foci, indicating that Mutator foci are partially reliant on RNA for their stability. Finally, we demonstrate that Mutator foci intensity is modulated by the stage of the germline cell cycle and specifically, that Mutator foci are brightest and most robust in the mitotic cells, transition zone, and late pachytene of adult germlines. Thus, our data defines several new factors that modulate Mutator foci morphology which may ultimately have implications for efficacy of RNAi in certain cell stages or environments.

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