Faculty Opinions recommendation of Histone recognition and large-scale structural analysis of the human bromodomain family.

Author(s):  
Cheng-Ming Chiang
2007 ◽  
Vol 17 (6) ◽  
pp. 928-939 ◽  
Author(s):  
J. H. Dennis ◽  
H.-Y. Fan ◽  
S. M. Reynolds ◽  
G. Yuan ◽  
J. C. Meldrim ◽  
...  

Author(s):  
Shalene Manzi ◽  
Roger L. Gibson ◽  
Asinne Tshibubudze

ABSTRACT Structural analysis of overturned metasedimentary strata of the lower Witwatersrand Supergroup in the inner collar of the Vredefort Dome reveals the presence of tangential folds and faults associated with the 2.02 Ga impact. The folds are distinct from previously identified subradially oriented, vertical to plunging-inclined, gentle folds that are interpreted as the products of convergent flow (constriction) during the initial stages of central uplift formation. The tangential folds comprise disharmonic, open, asymmetric, horizontal to plunging-inclined anticline-syncline pairs with centripetally dipping axial planes and right-way-up intermediate limbs. They display centripetal-down vergence (anticline radially outward of the syncline) that is consistent with steep inward-directed shear of the overturned strata. We attribute this kinematic pattern to subvertical collapse of the Vredefort central uplift during the latter stages of crater modification. The folds are cut by pseudotachylite-bearing steep to vertical tangential faults that display center-down slip of <10 m up to ~150 m. Both the tangential folds and the faults suggest that the large-scale overturning of strata related to outward collapse of the Vredefort central uplift was accompanied by a component of inward-directed collapse via layer-parallel shearing and folding, followed by faulting. Subradially oriented faults with conjugate strike separations of 1–2 km in the NNE collar of the dome suggest penecontemporaneous tangential extension of the inner collar rocks. This evidence indicates that second-order structures in the metasedimentary collar of the Vredefort Dome preserve a complex, multistage record of evolving strain associated with both initial convergent and upward flow (constriction) related to central uplift rise and later divergent and downward flow (flattening) linked to its collapse, and that centripetally directed collapse features may be important components of the structural inventory of very large central uplifts.


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