Faculty of 1000 evaluation for Endoglin in African children with Plasmodium falciparum malaria: a novel player in severe malaria pathogenesis?

2010 ◽  
Author(s):  
Charles Newton ◽  
Samson Gwer
Keyword(s):  
Plasmodium Falciparum ◽  
Severe Malaria ◽  
Falciparum Malaria ◽  
Plasmodium Falciparum Malaria ◽  
African Children

scholarly journals Predictors of treatment failures of plasmodium falciparum malaria in Vietnam: a 4-year single‐centre retrospective study

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Minh Cuong Duong ◽  
Oanh Kieu Nguyet Pham ◽  
Phong Thanh Nguyen ◽  
Van Vinh Chau Nguyen ◽  
Phu Hoan Nguyen
Keyword(s):  
Plasmodium Falciparum ◽  
Treatment Failure ◽  
Severe Malaria ◽  
Falciparum Malaria ◽  
Control Strategies ◽  
Artemisinin Resistance ◽  
Plasmodium Falciparum Malaria ◽  
Molecular Technique ◽  
Drug Resistant ◽  
Public Health Burden

Abstract Background Drug-resistant falciparum malaria is an increasing public health burden. This study examined the magnitude of Plasmodium falciparum infection and the patterns and predictors of treatment failure in Vietnam. Methods Medical records of all 443 patients with malaria infection admitted to the Hospital for Tropical Diseases between January 2015 and December 2018 were used to extract information on demographics, risk factors, symptoms, laboratory tests, treatment, and outcome. Results More than half (59.8%, 265/443, CI 55.1–64.4%) of patients acquired Plasmodium falciparum infection of whom 21.9% (58/265, CI 17.1–27.4%) had severe malaria, while 7.2% (19/265, CI 4.6–10.9%) and 19.2% (51/265, CI 14.7–24.5%) developed early treatment failure (ETF) and late treatment failure (LTF) respectively. Among 58 patients with severe malaria, 14 (24.1%) acquired infection in regions where artemisinin resistance has been documented including Binh Phuoc (11 patients), Dak Nong (2 patients) and Gia Lai (1 patient). Under treatment with intravenous artesunate, the median (IQR) parasite half-life of 11 patients coming from Binh Phuoc was 3 h (2.3 to 8.3 h), two patients coming from Dak Nong was 2.8 and 5.7 h, and a patient coming from Gia Lai was 6.5 h. Most patients (98.5%, 261/265) recovered completely. Four patients with severe malaria died. Severe malaria was statistically associated with receiving treatment at previous hospitals (P < 0.001), hepatomegaly (P < 0.001) and number of inpatient days (P < 0.001). Having severe malaria was a predictor of ETF (AOR 6.96, CI 2.55–19.02, P < 0.001). No predictor of LTF was identified. Conclusions Plasmodium falciparum remains the prevalent malaria parasite. Despite low mortality rate, severe malaria is not rare and is a significant predictor of ETF. To reduce the risk for ETF, studies are needed to examine the effectiveness of combination therapy including parenteral artesunate and a parenteral partner drug for severe malaria. The study alerts the possibility of drug-resistant malaria in Africa and other areas in Vietnam, which are known as non-endemic areas of anti-malarial drug resistance. A more comprehensive study using molecular technique in these regions is required to completely understand the magnitude of drug-resistant malaria and to design appropriate control strategies.

scholarly journals Plasmodium falciparum malaria and invasive bacterial co-infection in young African children: the dysfunctional spleen hypothesis

2014 ◽  
Vol 13 (1) ◽  
Author(s):  
Gloria P Gómez-Pérez ◽  
Robin van Bruggen ◽  
Martin P Grobusch ◽  
Carlota Dobaño
Keyword(s):  
Plasmodium Falciparum ◽  
Falciparum Malaria ◽  
Plasmodium Falciparum Malaria ◽  
African Children

Efficacy, safety and acceptability of halofantrine in the treatment of acute Plasmodium falciparum Malaria in African Children (Gabon)

1989 ◽  
Vol 5 ◽  
pp. 59-63 ◽  
Author(s):  
D. Richard-Lenoble ◽  
M. Kombila ◽  
M. Martz ◽  
D. Gendrel ◽  
C. Gendrel ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Falciparum Malaria ◽  
Plasmodium Falciparum Malaria ◽  
African Children

scholarly journals The effect of blood transfusion on outcomes among African children admitted to hospital with Plasmodium falciparum malaria: a prospective, multicentre observational study

2020 ◽  
Vol 7 (11) ◽  
pp. e789-e797 ◽  
Author(s):  
Hans Ackerman ◽  
Aintzane Ayestaran ◽  
Christopher H O Olola ◽  
Muminatou Jallow ◽  
Tsiri Agbenyega ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Blood Transfusion ◽  
Observational Study ◽  
Falciparum Malaria ◽  
Plasmodium Falciparum Malaria ◽  
African Children

scholarly journals Anaemia following Artemisinin-Based Combination Treatments of Uncomplicated Plasmodium falciparum Malaria in Children: Temporal Patterns of Haematocrit and the Use of Uncomplicated Hyperparasitaemia as a Model for Evaluating Late-Appearing Anaemia

Chemotherapy ◽  
2017 ◽  
Vol 62 (4) ◽  
pp. 231-238 ◽  
Author(s):  
Akin Sowunmi ◽  
Kazeem Akano ◽  
Godwin Ntadom ◽  
Adejumoke Ayede ◽  
Stephen Oguche ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Severe Malaria ◽  
Falciparum Malaria ◽  
Haemolytic Anaemia ◽  
Peripheral Blood ◽  
Temporal Patterns ◽  
Plasmodium Falciparum Malaria ◽  
Combination Treatments ◽  
High Parasitaemias ◽  
Uncomplicated Plasmodium Falciparum Malaria

Background: In severe malaria, intravenous artesunate may cause delayed haemolytic anaemia but there has been little evaluation of the propensity of oral artemisinin-based combination treatments (ACTs) to cause late-appearing anaemia. Methods: The frequency of anaemia (haematocrit <30%), and temporal changes in haematocrit were evaluated in 1,191 malarious children following ACTs. “Haematocrit conservation” was evaluated by using the fall in haematocrit/1,000 asexual parasites cleared from the peripheral blood (FIH/1,000 asexual parasites cpb), and the ratio of the average haematocrit (on the first 3 days of starting treatment):total parasitaemia cleared. Results: The frequency of anaemia decreased significantly following treatment. FIH/1,000 asexual parasites cpb, average haematocrit:total parasitaemia cleared, and mean haematocrit 5 weeks after treatment began were significantly lower in hyperparasitaemic children than in children without hyperparasitaemia, suggesting haematocrit conservation during treatment followed later by a loss of haematocrit. Asymptomatic late-appearing anaemia occurred in 6% of the children. Conclusion: Artesunate-amodiaquine and artemether-lumefantrine contribute to haematocrit conservation at high parasitaemias but may cause late-appearing anaemia.

Sign in / Sign up

Export Citation Format

Share Document