Faculty Opinions recommendation of Genome-wide transcriptional profiling reveals connective tissue mast cell accumulation in bronchopulmonary dysplasia.

2012 ◽  
Author(s):  
Vineet Bhandari
Keyword(s):  
Mast Cell ◽  
Connective Tissue ◽  
Bronchopulmonary Dysplasia ◽  
Transcriptional Profiling ◽  
Tissue Mast Cell ◽  
Genome Wide ◽  
Cell Accumulation

scholarly journals Genome-Wide Transcriptional Profiling Reveals Connective Tissue Mast Cell Accumulation in Bronchopulmonary Dysplasia

2012 ◽  
Vol 186 (4) ◽  
pp. 349-358 ◽  
Author(s):  
Soumyaroop Bhattacharya ◽  
Diana Go ◽  
Daria L. Krenitsky ◽  
Heidi L. Huyck ◽  
Siva Kumar Solleti ◽  
...  
Keyword(s):  
Mast Cell ◽  
Connective Tissue ◽  
Bronchopulmonary Dysplasia ◽  
Transcriptional Profiling ◽  
Tissue Mast Cell ◽  
Genome Wide ◽  
Cell Accumulation

scholarly journals Studies of connective tissue mast cell-mediated cytotoxicity

1989 ◽  
Vol 93 (3) ◽  
pp. 423-428 ◽  
Author(s):  
Michael D. Tharp ◽  
Candace Kasper ◽  
Dwain Thiele ◽  
Michael R. Charley ◽  
Donald A. Kennerly ◽  
...  
Keyword(s):  
Mast Cell ◽  
Connective Tissue ◽  
Tissue Mast Cell

Extracellular Localization of Human Connective Tissue Mast Cell Granule Contents

1990 ◽  
Vol 96 (6) ◽  
pp. 857-863 ◽  
Author(s):  
Michael S. Kaminer ◽  
Robert M. Lavker ◽  
Laurence J. Walsh ◽  
Diana. Whitaker ◽  
Burton. Zweiman
Keyword(s):  
Mast Cell ◽  
Connective Tissue ◽  
Cell Granule ◽  
Tissue Mast Cell ◽  
Mast Cell Granule

scholarly journals Mast Cells and Basophils in the Defense against Ectoparasites: Efficient Degradation of Parasite Anticoagulants by the Connective Tissue Mast Cell Chymases

2021 ◽  
Vol 22 (23) ◽  
pp. 12627
Author(s):  
Zhirong Fu ◽  
Srinivas Akula ◽  
Anna-Karin Olsson ◽  
Jukka Kervinen ◽  
Lars Hellman
Keyword(s):  
Mast Cell ◽  
Mast Cells ◽  
Connective Tissue ◽  
Blood Feeding ◽  
Cathepsin G ◽  
Human Mast Cell ◽  
Mucosal Mast Cell ◽  
Tissue Mast Cell ◽  
Tick Feeding

Ticks, lice, flees, mosquitos, leeches and vampire bats need to prevent the host’s blood coagulation during their feeding process. This is primarily achieved by injecting potent anticoagulant proteins. Basophils frequently accumulate at the site of tick feeding. However, this occurs only after the second encounter with the parasite involving an adaptive immune response and IgE. To study the potential role of basophils and mast cells in the defense against ticks and other ectoparasites, we produced anticoagulant proteins from three blood-feeding animals; tick, mosquito, and leech. We tested these anticoagulant proteins for their sensitivity to inactivation by a panel of hematopoietic serine proteases. The majority of the connective tissue mast cell proteases tested, originating from humans, dogs, rats, hamsters, and opossums, efficiently cleaved these anticoagulant proteins. Interestingly, the mucosal mast cell proteases that contain closely similar cleavage specificity, had little effect on these anticoagulant proteins. Ticks have been shown to produce serpins, serine protease inhibitors, upon a blood meal that efficiently inhibit the human mast cell chymase and cathepsin G, indicating that ticks have developed a strategy to inactivate these proteases. We show here that one of these tick serpins (IRS-2) shows broad activity against the majority of the mast cell chymotryptic enzymes and the neutrophil proteases from human to opossum. However, it had no effect on the mast cell tryptases or the basophil specific protease mMCP-8. The production of anticoagulants, proteases and anti-proteases by the parasite and the host presents a fascinating example of an arms race between the blood-feeding animals and the mammalian immune system with an apparent and potent role of the connective tissue mast cell chymases in the host defense.

scholarly journals A Connective Tissue Mast-Cell-Specific Receptor Detects Bacterial Quorum-Sensing Molecules and Mediates Antibacterial Immunity

2019 ◽  
Vol 26 (1) ◽  
pp. 114-122.e8 ◽  
Author(s):  
Priyanka Pundir ◽  
Rui Liu ◽  
Chirag Vasavda ◽  
Nadine Serhan ◽  
Nathachit Limjunyawong ◽  
...  
Keyword(s):  
Mast Cell ◽  
Quorum Sensing ◽  
Connective Tissue ◽  
Specific Receptor ◽  
Tissue Mast Cell ◽  
Bacterial Quorum Sensing ◽  
Bacterial Quorum

Catabolism of IgE by rat mucosal and connective tissue mast cell chymases

1990 ◽  
pp. 420-423 ◽  
Author(s):  
A McGuigan ◽  
G F J Newlands ◽  
R G Woodbury ◽  
H R P Miller
Keyword(s):  
Mast Cell ◽  
Connective Tissue ◽  
Tissue Mast Cell

scholarly journals TH9 cells are required for tissue mast cell accumulation during allergic inflammation

2015 ◽  
Vol 136 (2) ◽  
pp. 433-440.e1 ◽  
Author(s):  
Sarita Sehra ◽  
Weiguo Yao ◽  
Evelyn T. Nguyen ◽  
Nicole L. Glosson-Byers ◽  
Nahid Akhtar ◽  
...  
Keyword(s):  
Mast Cell ◽  
Allergic Inflammation ◽  
Tissue Mast Cell ◽  
Cell Accumulation ◽  
Th9 Cells
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