Faculty of 1000 evaluation for The role of different anesthetic techniques in altering the stress response during cardiac surgery in children: a prospective, double-blinded, and randomized study.

Increasing knowledge about the pathophysiology of the process leading to restenosis has given the rationale to investigate the potential role of radiation in the prevention of restenosis. Compared to the rapidly increasing experience in the coronary circulation, there is until now only a limited number of studies concerning the use of brachytherapy (BT) in the peripheral circulation. The-Vienna 2-Trial was the first randomized study to demonstrate the efficacy of endovascular BT for prophylaxis of restenosis after femoropopliteal percutaneous transluminal angioplasty. The cumulative patency rates at 12 months of follow-up were 63.6% in the PTA+BT-group and 35.3% in the PTA-group (p < 0.005), and the significant improvement in patency was also maintained after two years. The results of two ongoing randomized, double-blinded multicenter trials (PARIS; Vienna 3) have to be awaited before definitive recommendations can be given. The rather high incidence of late thrombotic occlusion after long-segment femoropopliteal stenting and endovascular BT requires optimization of the antithrombotic regimen.

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The Role of Adding Hyaluronidase to Fluoroscopically Guided Caudal Steroid and Hypertonic Saline Injection in Patients with Failed Back Surgery Syndrome: A Prospective, Double-Blinded, Randomized Study

Pain Practice ◽

10.1111/j.1533-2500.2009.00357.x ◽

2010 ◽

Vol 10 (6) ◽

pp. 548-553 ◽

Cited By ~ 26

Author(s):

Ayman Abd Al-Maksoud Yousef ◽

Ali Seif EL-deen ◽

Ali Ead Al-deeb

Keyword(s):

Hypertonic Saline ◽

Randomized Study ◽

Failed Back Surgery Syndrome ◽

Saline Injection ◽

Failed Back Surgery ◽

Back Surgery ◽

Hypertonic Saline Injection ◽

Double Blinded

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Gelatin Use Impairs Platelet Adhesion during Cardiac Surgery

Thrombosis and Haemostasis ◽

10.1055/s-0038-1649963 ◽

1995 ◽

Vol 74 (06) ◽

pp. 1447-1451 ◽

Cited By ~ 60

Author(s):

Norlyuki Tabuchi ◽

Jacob de Haan ◽

Rolf C G Gallandat Huet ◽

Plet W Boonstra ◽

Willem van Oeveren

Keyword(s):

Cardiac Surgery ◽

Platelet Adhesion ◽

Randomized Study ◽

High Dose ◽

Negative Effects ◽

Retrospective Clinical Study ◽

Heart Lung Machine ◽

Plug Formation

SummaryArtificial colloids based on gelatin are used as plasma expander to replace donor blood products. In laboratory experiments, gelatin reduced both the velocity and extend of platelet agglutination by ristocetin, and only the agglutination velocity by polybrene (p <0.05). Furthermore, gelatin delayed the in-vitro platelet plug formation under shear-stress in the absence of ADP (p <0.05), whereas gelatin induced no delay in the presence of ADP. Thus, after induction of vWF release from platelets by polybrene or ADP, platelet function was normal. These results indicate that gelatin affects in particular the functionality of plasma-vWF and partly inhibits platelet adhesion.These negative effects of gelatin on hemostasis were demonstrated in two clinical studies during cardiac surgery. In a randomized study of sixty patients undergoing cardiac surgery, gelatin as prime in the heart-lung machine appeared to result in diminished efficacy of aprotinin on hemostasis, whereas it did not affect hemostasis in non-aprotinin patients. An additional retrospective clinical study showed that only high dose of gelatin affected hemostasis. This suggests a limited role of plasma-vWF and a strong back-up mechanism of platelet-vWF in achieving hemostasis.

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