Faculty of 1000 evaluation for The United Kingdom Glaucoma Treatment Study: A Multicenter, Randomized, Double-masked, Placebo-controlled Trial: Baseline Characteristics.

Author(s):  
Elizabeth Hodapp
Author(s):  
Alan D. Penman ◽  
Kimberly W. Crowder ◽  
William M. Watkins

The United Kingdom Glaucoma Treatment Study (UKGTS) was a randomized, triple-masked, placebo-controlled trial comparing topical latanoprost, a prostaglandin analogue, with placebo in patients with newly diagnosed, previously untreated open-angle glaucoma (OAG). Compared to placebo, the latanoprost group showed a large, statistically significant reduction in the rate of glaucomatous visual field deterioration by 24 months. The UKGTS was the first placebo-controlled trial to show visual field preservation through lowering of intraocular pressure with topical drugs in patients with OAG, and the first to show the visual field–preserving effect of a topical prostaglandin analogue.


Ophthalmology ◽  
2013 ◽  
Vol 120 (12) ◽  
pp. 2540-2545 ◽  
Author(s):  
Gerassimos Lascaratos ◽  
David F. Garway-Heath ◽  
Robyn Burton ◽  
Catey Bunce ◽  
Wen Xing ◽  
...  

2003 ◽  
Vol 66 (5) ◽  
pp. 193-200 ◽  
Author(s):  
K H O Deane ◽  
C Ellis-Hill ◽  
K Dekker ◽  
P Davies ◽  
C E Clarke

Little is known about the current character of occupational therapy practice for Parkinson's disease in the United Kingdom. The study aimed to document this in order to inform plans for a future multicentre randomised controlled trial. Two hundred and forty-two occupational therapists that treated people with Parkinson's disease were sent a questionnaire regarding demographics, service organisation and therapy content. One hundred and sixty-nine occupational therapists (70%) responded. They had worked with people with Parkinson's disease for a median of 6 years and personally treated a median of 15 people with Parkinson's disease annually. Most (86%) were at senior grade or above; 87% worked in the National Health Service and 12% in social services. Forty per cent worked in specialist Parkinson's disease clinics. Most (79%) felt that they needed more specialist postgraduate training. Occupational therapists are employed in both health and social care settings. The character of the occupational therapy is often determined by the location in which it is provided. Current occupational therapy appears to focus on functional activities rather than on the wider social and psychological aspects of occupation. Many occupational therapists felt that they needed more specialist postgraduate training to treat people with Parkinson's disease effectively.


Ophthalmology ◽  
2013 ◽  
Vol 120 (1) ◽  
pp. 68-76 ◽  
Author(s):  
David F. Garway-Heath ◽  
Gerassimos Lascaratos ◽  
Catey Bunce ◽  
David P. Crabb ◽  
Richard A. Russell ◽  
...  

1973 ◽  
Vol 123 (575) ◽  
pp. 475-476 ◽  
Author(s):  
Alan J. Cooper ◽  
Ralph V. Magnus ◽  
Michael Rose ◽  
André Phanjoo ◽  
Neville P. Lancaster ◽  
...  

Dipotassium clorazepate is a new benzodiazepine derivative with pharmacological and clinical properties resembling diazepam. This report concerns a double-blind placebo-controlled crossover comparison of clorazepate and diazepam which was carried out simultaneously at four centres in the United Kingdom.


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