Faculty Opinions recommendation of Persistent effects of maternal smoking during pregnancy on lung function and asthma in adolescents.

2014 ◽  
Author(s):  
Harold Nelson
Keyword(s):  
Lung Function ◽  
Maternal Smoking ◽  
Smoking During Pregnancy ◽  
Maternal Smoking During Pregnancy

scholarly journals Genetic susceptibility to asthma increases the vulnerability to indoor air pollution

2020 ◽  
Vol 55 (3) ◽  
pp. 1901831 ◽  
Author(s):  
Anke Hüls ◽  
Aneesa Vanker ◽  
Diane Gray ◽  
Nastassja Koen ◽  
Julia L. MacIsaac ◽  
...  
Keyword(s):  
Air Pollution ◽  
Lung Function ◽  
Tract Infection ◽  
Indoor Air ◽  
Genetic Risk ◽  
Maternal Smoking ◽  
Lower Respiratory Tract ◽  
Indoor Air Pollution ◽  
Smoking During Pregnancy ◽  
Maternal Smoking During Pregnancy

IntroductionIndoor air pollution and maternal smoking during pregnancy are associated with respiratory symptoms in infants, but little is known about the direct association with lung function or interactions with genetic risk factors. We examined associations of exposure to indoor particulate matter with a 50% cut-off aerodynamic diameter of 10 µm (PM10) and maternal smoking with infant lung function and the role of gene–environment interactions.MethodsData from the Drakenstein Child Health Study, a South African birth cohort, were analysed (n=270). Lung function was measured at 6 weeks and 1 year of age, and lower respiratory tract infection episodes were documented. We measured pre- and postnatal PM10 exposures using devices placed in homes, and prenatal tobacco smoke exposure using maternal urine cotinine levels. Genetic risk scores determined from associations with childhood-onset asthma in the UK Biobank were used to investigate effect modifications.ResultsPre- and postnatal exposure to PM10 as well as maternal smoking during pregnancy were associated with reduced lung function at 6 weeks and 1 year as well as with lower respiratory tract infection in the first year. Due to a significant interaction between the genetic risk score and prenatal exposure to PM10, infants carrying more asthma-related risk alleles were more susceptible to PM10-associated reduced lung function (pinteraction=0.007). This interaction was stronger in infants with Black African ancestry (pinteraction=0.001) and nonexistent in children with mixed ancestry (pinteraction=0.876).ConclusionsPM10 and maternal smoking exposures were associated with reduced lung function, with a higher susceptibility for infants with an adverse genetic predisposition for asthma that also depended on the infant's ancestry.

The Effect of Maternal Smoking during Pregnancy on Early Infant Lung Function

1992 ◽  
Vol 145 (5) ◽  
pp. 1129-1135 ◽  
Author(s):  
John P. Hanrahan ◽  
Ira B. Tager ◽  
Mark R. Segal ◽  
Tor D. Tosteson ◽  
Robert G. Castile ◽  
...  
Keyword(s):  
Lung Function ◽  
Maternal Smoking ◽  
Smoking During Pregnancy ◽  
Early Infant ◽  
Maternal Smoking During Pregnancy

scholarly journals Tobacco smoke exposure in early life and adolescence in relation to lung function

2018 ◽  
Vol 51 (6) ◽  
pp. 1702111 ◽  
Author(s):  
Jesse D. Thacher ◽  
Erica S. Schultz ◽  
Jenny Hallberg ◽  
Ulrika Hellberg ◽  
Inger Kull ◽  
...  
Keyword(s):  
Lung Function ◽  
Tobacco Smoke ◽  
Maternal Smoking ◽  
Airway Resistance ◽  
Adolescent Smoking ◽  
Smoke Exposure ◽  
Tobacco Smoke Exposure ◽  
Smoking During Pregnancy ◽  
Maternal Smoking During Pregnancy ◽  
The Impact

Maternal smoking during pregnancy is associated with impaired lung function among young children, but less is known about long-term effects and the impact of adolescents' own smoking. We investigated the influence of maternal smoking during pregnancy, secondhand smoke exposure and adolescent smoking on lung function at age 16 years.The BAMSE (Barn/Child, Allergy, Milieu, Stockholm, Epidemiology) birth cohort collected information on participants' tobacco smoke exposure through repeated questionnaires, and measured saliva cotinine concentrations at age 16 years. Participants performed spirometry and impulse oscillometry (IOS) at age 16 years (n=2295).Exposure to maternal smoking during pregnancy was associated with reduced forced expiratory volume in 1 s (FEV1)/forced vital capacity (FVC) ratio of −1.1% (95% CI −2.0 to −0.2%). IOS demonstrated greater resistance at 5–20 Hz (R5–20) in participants exposed to maternal smoking during pregnancy. Adolescents who smoked had reduced FEV1/FVC ratios of −0.9% (95% CI −1.8 to −0.1%) and increased resistance of 6.5 Pa·L–1·s (95% CI 0.7 to 12.2 Pa·L–1·s) in R5–20. Comparable associations for FEV1/FVC ratio were observed for cotinine concentrations, using ≥12 ng·mL−1 as a cut-off for adolescent smoking.Maternal smoking during pregnancy was associated with lower FEV1/FVC ratios and increased airway resistance. In addition, adolescent smoking appears to be associated with reduced FEV1/FVC ratios and increased peripheral airway resistance.

Sign in / Sign up

Export Citation Format

Share Document