Faculty Opinions recommendation of Glycemic Control in Type 1 Diabetes and Long-Term Risk of Cardiovascular Events or Death After Coronary Artery Bypass Grafting.

Author(s):  
Wilbert Aronow
Circulation ◽  
2015 ◽  
Vol 132 (suppl_3) ◽  
Author(s):  
Martin Holzmann ◽  
Thomas Nyström ◽  
Ulrik Sartipy

Background: We performed a nationwide population-based cohort study to investigate the long-term risk of stroke after coronary artery bypass grafting (CABG) in patients with type 1 and type 2 diabetes. Hypothesis: Type 1 and type 2 diabetes is associated with an increased longterm risk of stroke after CABG. Methods and Results: All patients who underwent primary CABG in Sweden from 2000 through 2011 were included from the SWEDEHEART register. We excluded patients with prior stroke, and patients who had a stroke or died within 30 days of surgery. The National Diabetes Register was used to identify patients with type 1 and type 2 diabetes. Incident stroke (ischemic and hemorrhagic), and all-cause mortality was obtained by record linkage with the National Patient Register and the Cause of Death register. A total of 53 820 patients (type 1 diabetes (n=714), type 2 diabetes (n=10 054), no diabetes (n=43 052)) were included. During a mean follow-up of 7.4 years (398 337 person-years), in total, 8.0% (n=4 296) of the patients had a stroke: 7.3% (n=52) in patients with type 1 diabetes, 9.1% (n=915) in patients with type 2 diabetes, and 7.7% (n=3 329) in patients with no diabetes. The multivariable adjusted hazard ratio (95% confidence interval) for all stroke was 1.59 (1.20-2.11) in type 1 diabetes, and 1.32 (1.23-1.43) in type 2 diabetes compared to patients without diabetes. Figure 1 shows the age-adjusted cumulative incidence of stroke in relation to type 1 diabetes, type 2 diabetes and no diabetes. Conclusions: The long-term risk for stroke after CABG was higher in both patients with type 1 diabetes, and type 2 diabetes, compared to patients without diabetes.


Circulation ◽  
2015 ◽  
Vol 131 (20) ◽  
pp. 1748-1754 ◽  
Author(s):  
Magnus Dalén ◽  
Torbjörn Ivert ◽  
Martin J. Holzmann ◽  
Ulrik Sartipy

Background— There are limited data regarding long-term results after coronary artery bypass grafting (CABG) in young adults. We performed a nationwide population-based cohort study to analyze long-term survival, major adverse cardiovascular events, and factors associated with elevated risk in young adults undergoing CABG. Methods and Results— We included all adult patients ≤50 years of age who underwent primary isolated CABG in Sweden between 1997 and 2013 from the Swedish Web System for Enhancement and Development of Evidence-Based Care in Heart Disease Evaluated According to Recommended Therapies (SWEDEHEART) register. Patient data were linked from national Swedish health data registers to create a study database. We identified 4086 young adults with a mean age of 46 years and 18% women. During a median follow-up time of 10.9 years (interquartile range, 6.4–14.1) 490 (12%) patients died. Survival at 5, 10, and 15 years was 96% (95% CI, 95–96), 90% (95% CI, 89–91), and 82% (95%CI, 80–83), respectively, which was significantly better in comparison with patients aged 51 to 70 years and >70 years who underwent CABG during the same period. The cumulative incidence of death or a major adverse cardiovascular event during 17 years after CABG was mainly driven by myocardial infarction or the need for repeat revascularization. The most important risk factors for all-cause mortality were chronic kidney disease, reduced left ventricular ejection fraction, peripheral vascular disease, or chronic obstructive pulmonary disease. Conclusions— Long-term survival and freedom from major cardiovascular events after CABG was better in young adults than in older patients. Factors significantly associated with an elevated long-term risk of death or adverse outcome were similar to well-known risk factors for older age groups following CABG. Clinical Trial Registration— URL: http://www.clinicaltrials.gov . Unique identifier: NCT02276950.


2015 ◽  
Vol 65 (16) ◽  
pp. 1644-1652 ◽  
Author(s):  
Martin J. Holzmann ◽  
Björn Rathsman ◽  
Björn Eliasson ◽  
Jeanette Kuhl ◽  
Ann-Marie Svensson ◽  
...  

2021 ◽  
Vol 25 (1) ◽  
pp. 74
Author(s):  
A. N. Semchenko ◽  
I. V. Zaicev ◽  
A. M. Schevchenko ◽  
A. V. Semchenko

<p><strong>Background.</strong> At the present time there is no agreement regarding effect of revascularisation volume on long-term results of coronary artery bypass grafting. According to some reports, incomplete revascularisation, compared with complete revascularisation, affects survival and increases the frequency of adverse cardiovascular events. Other researchers do not find such differences.</p><p><strong>Aim.</strong> This study aimed to assess the influence of incomplete revascularisation on the long-term results of coronary bypass surgery and to determine its predictors.</p><p><strong>Methods.</strong> A total of 243 patients with coronary artery disease who underwent microscope-assisted coronary artery bypass surgery were categorised into two groups. Group I included those with complete revascularisation (n = 152), while group II included those with incomplete revascularisation (n = 91). When assigning patients to groups, the volume of achieved myocardial revascularisation was determined according to the patency of grafts. The groups were compared by the late survival and by the frequency of major cardiovascular events. Logistic regression was used to analyse predictors of incomplete revascularisation.</p><p><strong>Results.</strong> The median of follow-up (interquartile range) was 802 days (426–1487 days). Survival in group 1 at 1, 3 and 5 years after surgery was 98%, 98% and 89%, respectively, while in group 2, it was 90%, 86%, and 86%, respectively (p = 0.024). Freedom from major cardiovascular events (death, myocardial infarction, repeated revascularisation, stroke) in group 1 after 1, 3 and 5 years was 91%, 89% and 77%, respectively, and in group 2, it was 78%, 68% and 68%, respectively (p = 0.005). It was revealed that diabetes mellitus (odds ratio [OR] = 1.45, 95% confidence interval [CI] = 1.01–2.09), arteriosclerosis of arteries of two or more localisations (OR = 1.63, CI = 1.15–2.31), number of lesions in circumflex artery system (OR = 2.48, CI = 1.86–3.31), number of lesions in anterior descending artery system (OR = 1.61, CI = 1.14–2.28) and the diameter of the target coronary artery is less than 1.5 mm (OR = 1.3, CI = 1.22–2.38) are independent predictors of incomplete myocardial revascularisation during coronary artery bypass grafting. Male gender (OR = 0.61, CI = 0.41–0.91) and increased body mass index were associated with a reduced risk of incomplete revascularisation (OR = 0.96, CI = 0.93–0.99).</p><p><strong>Conclusion.</strong> Incomplete revascularisation worsens the prognosis after coronary bypass surgery, and is accompanied by an increase in the frequency of adverse cardiovascular events and a decrease in long-term survival. The risk of incomplete revascularisation increases in patients with diabetes mellitus, common manifestations of atherosclerosis, number of lesions in the left coronary system, as well as with a small diameter of the target coronary arteries. Male gender and increased body mass index were associated with a reduced risk of incomplete revascularisation.</p><p>Received 15 June 2020. Revised 23 July 2020. Accepted 24 July 2020.</p><p><strong>Funding:</strong> The study did not have sponsorship.</p><p><strong>Conflict of interest:</strong> Authors declare no conflict of interest.</p>


2000 ◽  
Vol 70 (3) ◽  
pp. 813-818 ◽  
Author(s):  
Dion L Franga ◽  
John M Kratz ◽  
A.Jackson Crumbley ◽  
James L Zellner ◽  
Martha R Stroud ◽  
...  

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