Faculty Opinions recommendation of Choroidal neovascularisation on optical coherence tomography angiography in punctate inner choroidopathy and multifocal choroiditis.

Purpose: To analyze the ability of optical coherence tomography angiography to identify choroidal neovascularization in multifocal choroiditis and to describe active and inactive choroidal neovascularization findings. Methods: Retrospective study of consecutive patients with multifocal choroiditis and choroidal neovascularization examined between January and November 2016. In addition to usual exams, optical coherence tomography angiography (AngioPlex™ CIRRUS™ HD-OCT model 5000; Carl Zeiss Meditec, Inc., Dublin, CA, USA) images were assessed for morphological analysis: choroidal neovascularization size, choroidal neovascularization margin (well or poorly circumscribed), choroidal neovascularization shape (tangled or interlacing), choroidal neovascularization core (feeder vessel) and dark ring around the choroidal neovascularization. Results: A total of 10 eyes were included. Optical coherence tomography angiography identified all choroidal neovascularization. Active choroidal neovascularization had well-circumscribed margins (67%), interlacing shape (83%), and a surrounding dark ring (83%). Inactive choroidal neovascularization had rather poorly circumscribed margins (75%), tangled shape, and “dead tree” appearance (50%) with less frequently a surrounding dark ring (50%). Conclusion: Optical coherence tomography angiography is adapted to confirm the diagnosis of choroidal neovascularization complicating multifocal choroiditis, but it is still insufficient to differentiate active and inactive lesions.

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Diagnostic algorithm utilising multimodal imaging including optical coherence tomography angiography for the detection of myopic choroidal neovascularisation

Eye ◽

10.1038/s41433-019-0378-2 ◽

2019 ◽

Vol 33 (7) ◽

pp. 1111-1118 ◽

Cited By ~ 2

Author(s):

Akanksha Bagchi ◽

Roy Schwartz ◽

Philip Hykin ◽

Sobha Sivaprasad

Keyword(s):

Optical Coherence Tomography ◽

Multimodal Imaging ◽

Optical Coherence Tomography Angiography ◽

Diagnostic Algorithm ◽

Choroidal Neovascularisation ◽

Optical Coherence

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Intravitreal ranibizumab for the management of serous maculopathy secondary to optic disc coloboma-associated choroidal neovascularisation

BMJ Case Reports ◽

10.1136/bcr-2020-235452 ◽

2021 ◽

Vol 14 (1) ◽

pp. e235452

Author(s):

Sarah Schimansky ◽

Xia Ni Wu ◽

Catherine Egan ◽

Quresh Mohamed

Keyword(s):

Optical Coherence Tomography ◽

Optic Nerve ◽

Optical Coherence Tomography Angiography ◽

Structural Response ◽

Choroidal Neovascularisation ◽

Fundus Examination ◽

Optical Coherence ◽

Intravitreal Ranibizumab ◽

Optic Disc Coloboma ◽

Optic Nerve Coloboma

We report the case of a 19-year-old patient with symptomatic unilateral serous maculopathy associated with an optic nerve coloboma. Fluorescein angiography detected a focal late leak at the temporal edge of the coloboma which was later found to correspond with an area of choroidal neovascularisation on optical coherence tomography angiography. A course of intravitreal ranibizumab achieved good clinical and structural response. This report contributes to the evidence that maculopathies associated with cavitary optic nerve anomalies may in some instances result from choroidal neovascularisation. It also highlights the importance of angiography to identify potential choroidal neovascular membranes, particularly in the absence of haemorrhages and neovascular membranes on fundus examination and conventional optical coherence tomography.

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The “Sponge sign”: A novel feature of inflammatory choroidal neovascularization

European Journal of Ophthalmology ◽

10.1177/1120672120917621 ◽

2020 ◽

pp. 112067212091762

Author(s):

Chiara Giuffrè ◽

Alessandro Marchese ◽

Giovanni Fogliato ◽

Elisabetta Miserocchi ◽

Giulio Maria Modorati ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Choroidal Neovascularization ◽

Choroidal Thickness ◽

Enhanced Depth Imaging ◽

Clinical Activity ◽

Optical Coherence ◽

Punctate Inner Choroidopathy ◽

Myopic Choroidal Neovascularization ◽

Multifocal Choroiditis ◽

Imaging Optical Coherence Tomography

Introduction: To investigate choroidal thickness changes related to the clinical activity of inflammatory choroidal neovascularization in punctate inner choroidopathy/multifocal choroiditis as compared to myopic choroidal neovascularization. Materials and methods: Consecutive inflammatory choroidal neovascularization secondary to punctate inner choroidopathy/multifocal choroiditis, and myopic choroidal neovascularization were retrospectively reviewed. By means of enhanced-depth imaging optical coherence tomography, choroidal thickness was assessed at the same location before choroidal neovascularization development, at choroidal neovascularization onset (baseline), and after treatment. Results: Eleven eyes with inflammatory choroidal neovascularization and 11 eyes with myopic choroidal neovascularization were analyzed. Choroidal thickness beneath inflammatory choroidal neovascularization significantly increased at baseline and decreased after therapy (“Sponge sign”), reaching preclinical values. In particular, mean choroidal thickness under inflammatory choroidal neovascularization was 145 ± 85 µm at the preclinical stage, increased to 210 ± 103 µm at baseline (p = 0.006), and decreased to 136 ± 87 µm after treatment (p = 0.017). Conversely, no significant choroidal thickness changes were disclosed in myopic choroidal neovascularization eyes, under any location. Conclusion: Optical coherence tomography–based choroidal thickness evaluation may represent an additional useful tool to monitor inflammatory choroidal neovascularization activity. Moreover, choroidal thickness under choroidal neovascularizations could be used to discriminate the origin of choroidal neovascular membrane, either inflammatory or myopic, in doubtful cases and guide the therapeutic management.

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Optical coherence tomography angiography in unilateral multifocal choroiditis and panuveitis

Medicine ◽

10.1097/md.0000000000014259 ◽

2019 ◽

Vol 98 (4) ◽

pp. e14259 ◽

Cited By ~ 2

Author(s):

Lung-Chi Lee ◽

Ke-Hao Huang ◽

Yi-Hao Chen ◽

Hsin-Ting Lin ◽

Chia-Chen Hsu ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Optical Coherence Tomography Angiography ◽

Optical Coherence ◽

Multifocal Choroiditis

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OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY AND WIDEFIELD FUNDUS AUTOFLUORESCENCE IN PUNCTATE INNER CHOROIDOPATHY

Retinal Cases & Brief Reports ◽

10.1097/icb.0000000000000203 ◽

2015 ◽

Vol 9 (4) ◽

pp. 323-326 ◽

Cited By ~ 7

Author(s):

Michael A. Klufas ◽

Thomas OʼHearn ◽

David Sarraf

Keyword(s):

Optical Coherence Tomography ◽

Optical Coherence Tomography Angiography ◽

Fundus Autofluorescence ◽

Optical Coherence ◽

Punctate Inner Choroidopathy

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Optical coherence tomography angiography findings in fellow eyes of choroidal neovascularisation associated with central serous chorioretinopathy

British Journal of Ophthalmology ◽

10.1136/bjophthalmol-2018-313576 ◽

2019 ◽

pp. bjophthalmol-2018-313576 ◽

Cited By ~ 3

Author(s):

Spoorti Krishna Reddy Mandadi ◽

Sumit Randhir Singh ◽

Niroj Kumar Sahoo ◽

Sai Bhakti Mishra ◽

Riccardo Sacconi ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Central Serous Chorioretinopathy ◽

Optical Coherence Tomography Angiography ◽

Choroidal Neovascularisation ◽

Vascular Network ◽

Conventional Imaging ◽

Optical Coherence ◽

Vascular Networks ◽

Chronic Central Serous Chorioretinopathy ◽

Fellow Eyes

AimTo evaluate the optical coherence tomography angiography (OCTA) features of fellow eyes of patients with unilateral choroidal neovascularisation (CNV) associated with chronic central serous chorioretinopathy (CSCR).MethodsMedical records of patients with chronic CSCR who had undergone OCT angiography of both the eyes were reviewed. Patients with evidence of unilateral CNV detected by conventional imaging (OCT, fluorescein angiography and/or indocyanine green angiography) were included in the study. The OCT and OCTA characteristics of fellow eyes were analysed.ResultsForty patients (80 eyes—40 fellow eyes) with chronic CSCR with evidence of CNV in one eye were included. Mean age of the patients was 54.9±9.9 years and 82.5 % were males. Twenty-five (62.5%) fellow eyes had flat irregular pigment epithelial detachment on OCT, out of which 21 had internal hyper-reflectivity. A definite vascular network was picked up by OCTA in 9 of these 40 fellow eyes (22.5%) which was not detected on conventional imaging. In addition, two eyes had an ill-defined hyper-reflectivity, which could not be classified as a definite network at that point of time. The networks detected on OCTA in fellow eyes were mostly inactive, suggesting a subclinical neovascularisation.ConclusionOne-fourth of fellow eyes showed vascular network which could not be diagnosed on conventional imaging which highlights the importance of imaging both the eyes of chronic CSCR for early detection of CNV using OCTA. Further longitudinal studies are needed to assess the clinical course of such subclinical vascular networks in CSCR.

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