Faculty Opinions recommendation of Impact of microbial invasion of amniotic cavity and the type of microorganisms on short-term neonatal outcome in women with preterm labor and intact membranes.

2017 ◽  
Author(s):  
Jeff Keelan
Keyword(s):  
Preterm Labor ◽  
Neonatal Outcome ◽  
Short Term ◽  
Amniotic Cavity ◽  
Microbial Invasion

scholarly journals Impact of microbial invasion of amniotic cavity and the type of microorganisms on short-term neonatal outcome in women with preterm labor and intact membranes

2017 ◽  
Vol 96 (5) ◽  
pp. 570-579 ◽  
Author(s):  
Teresa Cobo ◽  
Irene Vives ◽  
Adriano Rodríguez-Trujillo ◽  
Clara Murillo ◽  
Martina A. Ángeles ◽  
...  
Keyword(s):  
Preterm Labor ◽  
Neonatal Outcome ◽  
Short Term ◽  
Amniotic Cavity ◽  
Microbial Invasion

scholarly journals Amniotic Fluid Infection in Preterm Pregnancies with Intact Membranes

2017 ◽  
Vol 2017 ◽  
pp. 1-9 ◽  
Author(s):  
Tarja Myntti ◽  
Leena Rahkonen ◽  
Irmeli Nupponen ◽  
Anu Pätäri-Sampo ◽  
Minna Tikkanen ◽  
...  
Keyword(s):  
Amniotic Fluid ◽  
Preterm Labor ◽  
Molar Ratio ◽  
Amniotic Cavity ◽  
Culture Techniques ◽  
Reactive Protein ◽  
Molecular Microbiology ◽  
Microbial Invasion ◽  
Proteolytic Cascade ◽  
Singleton Pregnancies

Introduction. Intra-amniotic infection (IAI) is a major cause of preterm labor and adverse neonatal outcome. We evaluated amniotic fluid (AF) proteolytic cascade forming biomarkers in relation to microbial invasion of the amniotic cavity (MIAC) and IAI in preterm pregnancies with intact membranes. Material and Methods. Amniocentesis was made to 73 women with singleton pregnancies; 27 with suspected IAI; and 46 controls. AF biomarkers were divided into three cascades: Cascade 1: matrix metalloproteinase-8 (MMP-8), MMP-9, myeloperoxidase (MPO), and interleukin-6; Cascade 2: neutrophil elastase (HNE), elafin, and MMP-9; Cascade 3: MMP-2, tissue inhibitor of matrix metalloproteinases-1 (TIMP-1), MMP-8/TIMP-1 molar ratio, and C-reactive protein (CRP). MMP-8 was measured by an immunoenzymometric assay and the others were measured by ELISA. Standard biochemical methods, molecular microbiology, and culture techniques were used. Results. MMP-8, MMP-9, MPO, elafin, and TIMP-1 concentrations were higher in IAI suspected cases compared to controls and also in IAI suspected cases with MIAC compared to those without MIAC when adjusted by gestational age at amniocentesis. All biomarkers except elafin and MMP-2 had the sensitivity of 100% with thresholds based on ROC-curve. Odd ratios of biomarkers for MIAC were 1.2-38 and 95% confidential intervals 1.0-353.6. Conclusions. Neutrophil based AF biomarkers were associated with IAI and MIAC.

82: Detection of microbial invasion of the amniotic cavity by analysis of cervicovaginal proteins in preterm labor with intact membranes

2015 ◽  
Vol 212 (1) ◽  
pp. S57-S58
Author(s):  
C Andrew Combs ◽  
Jodi Lapidus ◽  
Michael Gravett ◽  
Thomas Garite ◽  
Jerome Lapointe
Keyword(s):  
Preterm Labor ◽  
Amniotic Cavity ◽  
Microbial Invasion

scholarly journals IgGFc-binding protein in pregnancies complicated by spontaneous preterm delivery: a retrospective cohort study

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Jaroslav Stranik ◽  
Marian Kacerovsky ◽  
Ondrej Soucek ◽  
Martina Kolackova ◽  
Ivana Musilova ◽  
...  
Keyword(s):  
Amniotic Fluid ◽  
Preterm Labor ◽  
Operating Characteristic ◽  
Binding Protein ◽  
Characteristic Curve ◽  
Enzyme Linked Immunosorbent Assay ◽  
Amniotic Cavity ◽  
Spontaneous Preterm Delivery ◽  
Microbial Invasion ◽  
Prelabor Rupture Of Membranes

AbstractTo determine the IgGFc-binding protein (FcgammaBP) concentration in amniotic and cervical fluids in preterm prelabor rupture of membranes (PPROM) and preterm labor with intact membranes (PTL) and to assess the diagnostic indices of FcgammaBP to predict intra-amniotic infection (the presence of both microbial invasion of the amniotic cavity and intra-amniotic inflammation). In this study, we included 170 and 79 women with PPROM and PTL, respectively. Paired cervical and amniotic fluid samples were obtained using a Dacron polyester swab and transabdominal amniocentesis, respectively. The FcgammaBP concentrations in the samples were assessed using an enzyme-linked immunosorbent assay. The presence of intra-amniotic infection was associated with elevated FcgammaBP concentrations in pregnancies with PPROM and PTL [PPROM—presence: 86 ng/mL vs. absence: 13 ng/mL, p < 0.0001, area under receiver operating characteristic curve (AUC) = 0.94; PTL—presence: 140 ng/mL vs. absence: 22 ng/mL, p < 0.0001, AUC = 0.86]. In cervical fluid, the concentrations of FcgammaBP were elevated in the presence of intra-amniotic infection in pregnancies with PPROM only (presence: 345 ng/mL vs. absence: 60 ng/mL, p < 0.0001, AUC = 0.93). FcgammaBP in amniotic fluid might be a marker of intra-amniotic infection in women with both PPROM and PTL However, in cervical fluid, it is only observed in women with PPROM.

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