Faculty Opinions recommendation of Slow wave sleep disruption increases cerebrospinal fluid amyloid-β levels.

Slow-wave sleep (SWS) and rapid-eye-movement sleep (REM) were recorded in cats for 32 h a) under control conditions, b) following intraventricular infusions of artificial cerebrospinal fluid (CSF), and c) following infusions of sleep-promoting factor S prepared from human urine (SPU). During the first 12 h after receiving artificial CSF, the cats slept 4.9 +/- 0.2 h in slow-wave sleep (SWS) and 1.4 +/- 0.1 h in REM. Similar values were obtained from the same cats under control conditions. After infusions of SPU, the duration of SWS in the same cats increased to an average of 6.9 +/- 0.5 h with no significant change in REM averaged over 12 h; a transient decrease of REM in the first 4 h was fully compensated in subsequent hours. The increased SWS induced by the sleep-promoting factor from human urine subsided after 12 h, and there was no compensatory increase in wakefulness during the subsequent 20 h. The normal sleep cycle was not affected. In cats, therefore, the primary effect of SPU is to increase normal SWS, with little effect on REM.

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Effect of Slow Wave Sleep Disruption on Metabolic Parameters in Adolescents

SLEEP ◽

10.5665/sleep.6028 ◽

2016 ◽

Vol 39 (8) ◽

pp. 1591-1599 ◽

Cited By ~ 15

Author(s):

Natalie D. Shaw ◽

Andrew W. McHill ◽

Michele Schiavon ◽

Tairmae Kangarloo ◽

Piotr W. Mankowski ◽

...

Keyword(s):

Slow Wave ◽

Slow Wave Sleep ◽

Metabolic Parameters ◽

Sleep Disruption

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Targeted memory reactivation of face-name learning depends on ample and undisturbed slow-wave sleep

npj Science of Learning ◽

10.1038/s41539-021-00119-2 ◽

2022 ◽

Vol 7 (1) ◽

Author(s):

Nathan W. Whitmore ◽

Adrianna M. Bassard ◽

Ken A. Paller

Keyword(s):

Slow Wave ◽

Slow Wave Sleep ◽

Social Contexts ◽

Background Music ◽

Sleep Disruption ◽

Memory Functions ◽

Face Memory ◽

Memory Reactivation ◽

Two Factors ◽

Daytime Nap

AbstractFace memory, including the ability to recall a person’s name, is of major importance in social contexts. Like many other memory functions, it may rely on sleep. We investigated whether targeted memory reactivation during sleep could improve associative and perceptual aspects of face memory. Participants studied 80 face-name pairs, and then a subset of spoken names with associated background music was presented unobtrusively during a daytime nap. This manipulation preferentially improved name recall and face recognition for those reactivated face-name pairs, as modulated by two factors related to sleep quality; memory benefits were positively correlated with the duration of stage N3 sleep (slow-wave sleep) and negatively correlated with measures of sleep disruption. We conclude that (a) reactivation of specific face-name memories during sleep can strengthen these associations and the constituent memories, and that (b) the effectiveness of this reactivation depends on uninterrupted N3 sleep.

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5-Hydroxyindoleacetic acid in cerebrospinal fluid: an indicator of slow-wave sleep

Brain Research ◽

10.1016/0006-8993(75)90052-9 ◽

1975 ◽

Vol 99 (2) ◽

pp. 440-443 ◽

Cited By ~ 16

Author(s):

R.L. Buckingham ◽

M. Radulovacˇki

Keyword(s):

Cerebrospinal Fluid ◽

Slow Wave ◽

Slow Wave Sleep ◽

Hydroxyindoleacetic Acid

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Automated slow wave sleep disruption in middle-aged adults

Sleep Medicine ◽

10.1016/j.sleep.2015.02.037 ◽

2015 ◽

Vol 16 ◽

pp. S16

Author(s):

S. Ooms ◽

J. Zempel ◽

D. Holtzman ◽

Y. Ju

Keyword(s):

Slow Wave ◽

Slow Wave Sleep ◽

Sleep Disruption ◽

Middle Aged ◽

Middle Aged Adults

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Performance and sleepiness following moderate sleep disruption and slow wave sleep deprivation

Physiology & Behavior ◽

10.1016/s0031-9384(86)80012-9 ◽

1986 ◽

Vol 37 (6) ◽

pp. 915-918 ◽

Cited By ~ 57

Author(s):

M.H. Bonnet

Keyword(s):

Sleep Deprivation ◽

Slow Wave ◽

Slow Wave Sleep ◽

Sleep Disruption

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Targeted Memory Reactivation of Face-Name Learning Depends on Ample and Undisturbed Slow-Wave Sleep

10.1101/2021.02.16.431530 ◽

2021 ◽

Author(s):

Nathan Whitmore ◽

Adrianna M. Bassard ◽

Ken A. Paller

Keyword(s):

Slow Wave ◽

Slow Wave Sleep ◽

Sleep Disruption ◽

Face Memory ◽

Memory Reactivation ◽

Two Factors ◽

Daytime Nap ◽

Electroencephalographic Activity ◽

Familiar Person

AbstractFace memory, including the ability to recall the name of a familiar person, is often crucial in social interactions, and like many other memory functions, it may rely on sleep. We investigated whether targeted memory reactivation during sleep could improve associative and perceptual aspects of face memory. Participants studied 80 face-name pairs, and then a subset of spoken names was presented unobtrusively during a daytime nap. This reactivation preferentially improved recall for those face-name pairs, as modulated by two factors related to sleep quality. That is, the memory benefit was positively correlated with the duration of stage N3 sleep (slow-wave sleep) and with the extent to which cues presented during SWS did not produce a sleep disruption indexed by increased alpha-band electroencephalographic activity in the 5 seconds after a cue. Follow-up analyses showed that a memory benefit from presenting spoken names during sleep was evident in participants with high amounts of SWS or with low amounts of sleep disruption. We conclude that sleep reactivation can strengthen memory for specific face-name associations and that the effectiveness of reactivation depends on uninterrupted N3 sleep.

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