Faculty Opinions recommendation of Intravenous fluid therapy in critically ill adults.

2018 ◽  
Author(s):  
Paul H Mayo ◽  
Karan Singh
Keyword(s):  
Critically Ill ◽  
Fluid Therapy ◽  
Intravenous Fluid ◽  
Intravenous Fluid Therapy ◽  
Critically Ill Adults ◽  
Ill Adults

scholarly journals Author Correction: Intravenous fluid therapy in critically ill adults

2018 ◽  
Vol 14 (11) ◽  
pp. 717-717
Author(s):  
Simon Finfer ◽  
John Myburgh ◽  
Rinaldo Bellomo
Keyword(s):  
Critically Ill ◽  
Fluid Therapy ◽  
Intravenous Fluid ◽  
Intravenous Fluid Therapy ◽  
Critically Ill Adults ◽  
Ill Adults

scholarly journals Intravenous fluid therapy in critically ill adults

2018 ◽  
Vol 14 (9) ◽  
pp. 541-557 ◽  
Author(s):  
Simon Finfer ◽  
John Myburgh ◽  
Rinaldo Bellomo
Keyword(s):  
Critically Ill ◽  
Fluid Therapy ◽  
Intravenous Fluid ◽  
Intravenous Fluid Therapy ◽  
Critically Ill Adults ◽  
Ill Adults

scholarly journals Intravenous Fluid Management in Critically Ill Adults: A Review

2020 ◽  
Vol 40 (6) ◽  
pp. e17-e27
Author(s):  
Ashley Barlow ◽  
Brooke Barlow ◽  
Nancy Tang ◽  
Bhavik M. Shah ◽  
Amber E. King
Keyword(s):  
Critical Care ◽  
Critically Ill ◽  
Fluid Therapy ◽  
Intravenous Fluid ◽  
Patient Specific ◽  
Intravenous Fluids ◽  
Salt Solutions ◽  
Intravenous Fluid Therapy ◽  
Critically Ill Adults ◽  
Ill Adults

Topic This article reviews the management of intravenous fluids and the evaluation of volume status in critically ill adults. Clinical Relevance Intravenous fluid administration is one of the most common interventions in the intensive care unit. Critically ill patients have dynamic fluid requirements, making the management of fluid therapy challenging. New literature suggests that balanced salt solutions may be preferred in some patient populations. Purpose of Paper The bedside critical care nurse must understand the properties of various intravenous fluids and their corresponding impact on human physiology. The nurse’s clinical and laboratory assessments of each patient help define the goals of fluid therapy, which will in turn be used to determine the optimal patient-specific selection and dose of fluid for administration. Nurses serve a vital role in monitoring the safety and efficacy of intravenous fluid therapy. Although this intervention can be lifesaving, inappropriate use of fluids has the potential to yield detrimental effects. Content Covered This article discusses fluid physiology and the goals of intravenous fluid therapy, compares the types of intravenous fluids (isotonic crystalloids, including 0.9% sodium chloride and balanced salt solutions; hypotonic and hypertonic crystalloids; and colloids) and their adverse effects and impact on hemodynamics, and describes the critical care nurse’s essential role in selecting and monitoring intravenous fluid therapy.

scholarly journals 0.9% Sodium chloride solution versus Plasma-Lyte 148 versus compound sodium lacTate solution in children admitted to PICU—a randomized controlled trial (SPLYT-P): study protocol for an intravenous fluid therapy trial

Trials ◽  
2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Sainath Raman ◽  
Andreas Schibler ◽  
Renate Le Marsney ◽  
Peter Trnka ◽  
Melanie Kennedy ◽  
...  
Keyword(s):  
Sodium Chloride ◽  
Critically Ill ◽  
Fluid Therapy ◽  
Controlled Trial ◽  
Sodium Lactate ◽  
Intravenous Fluid ◽  
Critically Ill Children ◽  
Open Label ◽  
Intravenous Fluid Therapy ◽  
Balanced Solutions

Abstract Background Intravenous fluid therapy represents the most common intervention critically ill patients are exposed to. Hyperchloremia and metabolic acidosis associated with 0.9% sodium chloride have been observed to lead to worse outcomes, including mortality. Balanced solutions, such as Plasma-Lyte 148 and Compound Sodium Lactate, represent potential alternatives but the evidence on optimal fluid choices in critically ill children remains scarce. This study aims to demonstrate whether balanced solutions, when used as intravenous fluid therapy, are able to reduce the incidence of a rise in serum chloride level compared to 0.9% sodium chloride in critically ill children. Methods This is a single-centre, open-label randomized controlled trial with parallel 1:1:1 assignment into three groups: 0.9% sodium chloride, Plasma-Lyte 148, and Compound Sodium Lactate solutions for intravenous fluid therapy. The intervention includes both maintenance and bolus fluid therapy. Children aged < 16 years admitted to intensive care and receiving intravenous fluid therapy during the first 4 h of admission are eligible. The primary outcome measure is a ≥ 5mmol/L increase in serum chloride level within 48 h post-randomization. The enrolment target is 480 patients. The main analyses will be intention-to-treat. Discussion This study tests three types of intravenous fluid therapy in order to compare the risk of hyperchloremia associated with normal saline versus balanced solutions. This pragmatic study is thereby assessing the most common intervention in paediatric critical care. This is a single-centre open-label study with no blinding at the level of delivery of the intervention. Certain paediatric intensive care unit (PICU) patient groups such as those admitted with a cardiac condition or following a traumatic brain injury are excluded from this study. Trial registration The study has received ethical approval (HREC/19/QCHQ/53177: 06/06/2019). It is registered in the Australian New Zealand Clinical Trials Registry (ACTRN12619001244190) from 9th September 2019. Recruitment commenced on 12th November 2019. The primary results manuscript will be published in a peer-reviewed journal.

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