Faculty Opinions recommendation of Aminopyrazole Carboxamide Bruton’s Tyrosine Kinase Inhibitors. Irreversible to Reversible Covalent Reactive Group Tuning

2019 ◽  
Author(s):  
John Lowe
Keyword(s):  
Tyrosine Kinase ◽  
Tyrosine Kinase Inhibitors ◽  
Kinase Inhibitors ◽  
Bruton’S Tyrosine Kinase ◽  
Reactive Group ◽  
Bruton's Tyrosine Kinase ◽  
Reversible Covalent

scholarly journals Aminopyrazole Carboxamide Bruton’s Tyrosine Kinase Inhibitors. Irreversible to Reversible Covalent Reactive Group Tuning

2018 ◽  
Vol 10 (1) ◽  
pp. 80-85 ◽  
Author(s):  
Mark E. Schnute ◽  
Stephen E. Benoit ◽  
Ingrid P. Buchler ◽  
Nicole Caspers ◽  
Margaret L. Grapperhaus ◽  
...  
Keyword(s):  
Tyrosine Kinase ◽  
Tyrosine Kinase Inhibitors ◽  
Kinase Inhibitors ◽  
Bruton’S Tyrosine Kinase ◽  
Reactive Group ◽  
Bruton's Tyrosine Kinase ◽  
Reversible Covalent

scholarly journals Discovery and biological evaluation of N5-substituted 6,7-dioxo-6,7-dihydropteridine derivatives as potent Bruton's tyrosine kinase inhibitors

MedChemComm ◽  
2018 ◽  
Vol 9 (4) ◽  
pp. 697-704 ◽  
Author(s):  
Haiyang Chen ◽  
Peiran Song ◽  
Yanyan Diao ◽  
Yongjia Hao ◽  
Dou Dou ◽  
...  
Keyword(s):  
Tyrosine Kinase ◽  
Enzymatic Activity ◽  
Tyrosine Kinase Inhibitors ◽  
Kinase Inhibitors ◽  
Biological Evaluation ◽  
Bruton’S Tyrosine Kinase ◽  
Bruton's Tyrosine Kinase

Compound6potently inhibited the enzymatic activity of BTK with an IC50value of 1.9 nM.

Sign in / Sign up

Export Citation Format

Share Document