Faculty Opinions recommendation of Effect of catheter ablation vs antiarrhythmic drug therapy on mortality, stroke, bleeding, and cardiac arrest among patients with atrial fibrillation: the CABANA randomized clinical trial.

2019 ◽  
Author(s):  
Wilbert Aronow
Keyword(s):  
Atrial Fibrillation ◽  
Clinical Trial ◽  
Cardiac Arrest ◽  
Drug Therapy ◽  
Catheter Ablation ◽  
Randomized Clinical Trial ◽  
Antiarrhythmic Drug ◽  
Antiarrhythmic Drug Therapy

scholarly journals Effect of Catheter Ablation vs Antiarrhythmic Drug Therapy on Mortality, Stroke, Bleeding, and Cardiac Arrest Among Patients With Atrial Fibrillation

JAMA ◽  
2019 ◽  
Vol 321 (13) ◽  
pp. 1261 ◽  
Author(s):  
Douglas L. Packer ◽  
Daniel B. Mark ◽  
Richard A. Robb ◽  
Kristi H. Monahan ◽  
Tristram D. Bahnson ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Cardiac Arrest ◽  
Drug Therapy ◽  
Catheter Ablation ◽  
Antiarrhythmic Drug ◽  
Antiarrhythmic Drug Therapy

scholarly journals Antiarrhythmic drug therapy after catheter ablation for atrial fibrillation has no impact on recurrences, cardiovascular events and mortality – insights from the German Ablation Registry

2021 ◽  
Vol 42 (Supplement_1) ◽  
Author(s):  
R Schleberger ◽  
A Metzner ◽  
K H Kuck ◽  
D Andresen ◽  
S Willems ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Drug Therapy ◽  
Catheter Ablation ◽  
Antiarrhythmic Drug ◽  
Treatment Satisfaction ◽  
Cardiovascular Events ◽  
Patient Reported Outcome ◽  
Antiarrhythmic Drug Therapy ◽  
Funding Sources ◽  
Patient Reported

Abstract Background Data on the optimal treatment strategy for antiarrhythmic drug therapy (AAD) after atrial fibrillation (AF) catheter ablation are inconsistent. While AAD potentially stabilizes sinus rhythm, it also increases the patients' treatment burden. Methods Patients from the prospective German Ablation Registry (n=3275) discharged with or without AAD after AF catheter ablation were compared regarding long-term success, cardiovascular events and patient reported outcome. Results In patients with paroxysmal AF (n=2138) recurrence and rehospitalization rates did not differ when discharged with (n=1051) or without (n=1087) AAD (recurrence: adjusted odds ratio (OR) 1.13, 95% confidence interval (CI) [0.95–1.35]; rehospitalization: OR 1.08, 95% CI [0.90–1.30]). The reablation rate was higher and reduced treatment satisfaction was reported more often in those discharged with AAD (reablation: OR 1.30, 95% CI [1.05–1.61]; reduced treatment satisfaction: OR 1.76, 95% CI [1.20–2.58]). Similar rates of recurrences, rehospitalisations, reablations and treatment satisfaction were found in patients with persistent AF (n=1137) discharged with (n=641) or without (n=496) AAD (recurrence: OR 1.22, 95% CI [0.95–1.56]; rehospitalization: OR 1.16, 95% CI [0.90–1.50]; reablation: OR 1.21, 95% CI [0.91–1.61]; treatment satisfaction: OR 1.24, 95% CI [0.74–2.08]). The incidence of cardiovascular events and mortality did not differ at follow-up in paroxysmal and persistent AF patients discharged with or without AAD. Conclusion The rates of recurrences, cardiovascular events and mortality did not differ between patients discharged with or without AAD after AF catheter ablation. However, AAD should be considered carefully in patients with paroxysmal AF, in whom it was associated with a higher reablation rate and reduced treatment satisfaction. FUNDunding Acknowledgement Type of funding sources: None.

scholarly journals Catheter Ablation versus Antiarrhythmic Drug Therapy for Atrial Fibrillation (CABANA) Trial: Study Rationale and Design

2018 ◽  
Vol 199 ◽  
pp. 192-199 ◽  
Author(s):  
Douglas L. Packer ◽  
Daniel B. Mark ◽  
Richard A Robb ◽  
Kristi H. Monahan ◽  
Tristram D. Bahnson ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Drug Therapy ◽  
Catheter Ablation ◽  
Antiarrhythmic Drug ◽  
Antiarrhythmic Drug Therapy

scholarly journals Impact of postprocedural antiarrhythmic drug therapy with bepridil on maintaining sinus rhythm after catheter ablation for persistent atrial fibrillation

2016 ◽  
Vol 68 (3) ◽  
pp. 229-235 ◽  
Author(s):  
Takehito Kondo ◽  
Junichiro Miake ◽  
Masaru Kato ◽  
Kazuyoshi Ogura ◽  
Kazuhiko Iitsuka ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Drug Therapy ◽  
Catheter Ablation ◽  
Sinus Rhythm ◽  
Antiarrhythmic Drug ◽  
Persistent Atrial Fibrillation ◽  
Antiarrhythmic Drug Therapy

scholarly journals Recurrence of Atrial Fibrillation After Catheter Ablation or Antiarrhythmic Drug Therapy in the CABANA Trial

2020 ◽  
Vol 75 (25) ◽  
pp. 3105-3118 ◽  
Author(s):  
Jeanne E. Poole ◽  
Tristram D. Bahnson ◽  
Kristi H. Monahan ◽  
George Johnson ◽  
Hoss Rostami ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Drug Therapy ◽  
Catheter Ablation ◽  
Antiarrhythmic Drug ◽  
Antiarrhythmic Drug Therapy
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