Faculty Opinions recommendation of Effect of Statin Therapy and Long-Term Mortality Following Transcatheter Aortic Valve Implantation.

2019 ◽  
Author(s):  
Wilbert Aronow
Keyword(s):  
Aortic Valve ◽  
Statin Therapy ◽  
Transcatheter Aortic Valve Implantation ◽  
Transcatheter Aortic Valve ◽  
Aortic Valve Implantation ◽  
Valve Implantation ◽  
Long Term Mortality

Effect of Statin Therapy and Long-Term Mortality Following Transcatheter Aortic Valve Implantation

2019 ◽  
Vol 123 (12) ◽  
pp. 1978-1982 ◽  
Author(s):  
Ilan Merdler ◽  
Zach Rozenbaum ◽  
Ariel Finkelstein ◽  
Yaron Arbel ◽  
Shmuel Banai ◽  
...  
Keyword(s):  
Aortic Valve ◽  
Statin Therapy ◽  
Transcatheter Aortic Valve Implantation ◽  
Transcatheter Aortic Valve ◽  
Aortic Valve Implantation ◽  
Valve Implantation ◽  
Long Term Mortality

Impact of significant paravalvular leaks after transcatheter aortic valve implantation on anaemia and mortality

Heart ◽  
2020 ◽  
pp. heartjnl-2020-316941
Author(s):  
Javier Lopez-Pais ◽  
Diego Lopez-Otero ◽  
Arturo Garcia-Touchard ◽  
Barbara Izquierdo Coronel ◽  
Pablo José Antúnez Muiños ◽  
...  
Keyword(s):  
Aortic Valve ◽  
Transcatheter Aortic Valve Implantation ◽  
Cox Regression ◽  
Independent Predictor ◽  
Paravalvular Leak ◽  
Transcatheter Aortic Valve ◽  
Aortic Valve Implantation ◽  
Valve Implantation ◽  
Long Term Mortality

ObjectiveThe aim of this work is to assess the relationship between significant paravalvular leak (SPL) after transcatheter aortic valve implantation (TAVI) on anaemia and their impact on prognosis.MethodsObservational analytic study developed at two university hospitals, including all consecutive patients who underwent TAVI during a 10-year period (2009 to 2018). A logistic regression model was created to determine independent predictors of anaemia at 3 months. Time to event outcomes were analysed with Cox regression. Median follow-up was 21.3±21.9 months.Results788 patients were included. 5.3% had SPL. SPL was an independent predictor of anaemia 3 months after TAVI (OR: 8.31, 95% CI: 2.06 to 33.50). SPL and anaemia at 3 months were independently associated with long-term mortality (HR: 1.82, 95% CI: 1.16 to 2.85; HR: 2.07, 95% CI: 1.39 to 3.08).ConclusionSPL is an independent predictor of anaemia at 3 months after TAVI, a condition that doubles long-term mortality. Our findings could explain in part the worse prognosis of SPL after TAVI. Further pathophysiological studies are necessary to explain this association.

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