Faculty Opinions recommendation of Histological evidence supports low anesthetic bladder capacity as a marker of a bladder-centric disease subtype in interstitial cystitis/bladder pain syndrome.

Abstract IntroductionIn patients with interstitial cystitis or bladder pain syndrome (IC/BPS), 85% were found to have pelvic floor myofascial pain (PFMP) and hypertonicity (PFH). However, they are not typically trained to consider or assess PFMP as a contributing factor to patients’ IC/BPS symptoms. This study aimed to explore the relationship between PFMP and treatment outcomes in women with IC/BPS.MethodsPatients with IC/BPS who received any type of treatment were prospectively enrolled. They underwent vaginal digital examination at baseline. PFMP severity was quantified on the visual analog scale (VAS). Subject assessment items included O’Leary-Sant symptom score (OSS), Global Response Assessment (GRA), and Beck’s anxiety inventory. Object assessment items included bladder computed tomography (CT), urodynamic parameters, maximum bladder capacity, and grade of glomerulation.ResultsA total of 65 women with IC/BPS (mean age, 57.1 ± 11.3 years) were enrolled in the study. Patients with more severe PFMP had significantly higher rate of dyspareunia (p = .031); more comorbidities (p = .010); higher number of PFMP sites (p < .001); and higher OSS (p = .012). PFMP severity was not significantly correlated with bladder conditions, whether subjective or objective. Moreover, PFMP severity (VAS) was significantly negatively associated with GRA score.ConclusionPFMP might affect the subjective results of IC/BPS treatment but not the bladder condition. Therefore, in the future treatment of patients with IC/BPS, digital vaginal examinations of pelvic floor muscles should be performed and focused more on the PFM-related conditions, and necessary PFM treatments, such as the vaginal pelvic floor muscle message, should be scheduled.

Download Full-text

Large anesthetic bladder capacity is predictive of better response to hydrodistention in interstitial cystitis/bladder pain syndrome

European Urology Open Science ◽

10.1016/s2666-1683(20)33682-x ◽

2020 ◽

Vol 19 ◽

pp. e1621

Author(s):

C. Tsai ◽

Y. Fan ◽

A.T.L. Lin ◽

W.J. Huang

Keyword(s):

Interstitial Cystitis ◽

Pain Syndrome ◽

Bladder Capacity ◽

Bladder Pain Syndrome ◽

Bladder Pain

Download Full-text

Faculty Opinions recommendation of Bladder hydrodistention does not result in a significant change in bladder capacity for interstitial cystitis/bladder pain syndrome patients.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.736187602.793562809 ◽

2019 ◽

Author(s):

Pradeep Tyagi

Keyword(s):

Interstitial Cystitis ◽

Pain Syndrome ◽

Bladder Capacity ◽

Bladder Pain Syndrome ◽

Bladder Pain ◽

Significant Change

Download Full-text

The effects of cystoscopy and hydrodistention on symptoms and bladder capacity in interstitial cystitis/bladder pain syndrome

Neurourology and Urodynamics ◽

10.1002/nau.23555 ◽

2018 ◽

Vol 37 (6) ◽

pp. 2002-2007 ◽

Cited By ~ 3

Author(s):

Peter S. Kirk ◽

Yahir Santiago-Lastra ◽

Yongmei Qin ◽

John T. Stoffel ◽

James Q. Clemens ◽

...

Keyword(s):

Interstitial Cystitis ◽

Pain Syndrome ◽

Bladder Capacity ◽

Bladder Pain Syndrome ◽

Bladder Pain

Download Full-text

Bladder neck stenosis surgery in interstitial cystitis / bladder pain syndrome treatment

Urologicheskie vedomosti ◽

10.17816/uroved1015-10 ◽

2020 ◽

Vol 10 (1) ◽

pp. 5-10

Author(s):

Vladimir L. Medvedev ◽

Igor V. Mihailov ◽

Sergey N. Lepetunov ◽

Yuriy N. Medoev ◽

Mikhail I. Kogan

Keyword(s):

Interstitial Cystitis ◽

Flow Rate ◽

Bladder Neck ◽

Pain Syndrome ◽

Bladder Capacity ◽

Bladder Pain Syndrome ◽

Urinary Flow ◽

Residual Volume ◽

Urinary Frequency ◽

Bladder Pain

Introduction. Current methods of interstitial cystitis / bladder pain syndrome (IC/BPS) treatment dont allow to achieve long-term clinical remission. Aim of the study was to investigate the clinical efficacy of bladder neck transurethral incision (TUI) in women with IC/BPS, who had bladder outlet obstruction signs. Materials and methods. TUI was performed to patients with IC/BPS and proven bladder neck stenosis (n = 29). Assessment of the results of this operation was provided after 1, 3 and 6 months after surgical treatment. Treatment efficacy was evaluated by using Global Response Assessment (GRA) Scale, Pelvic Pain and Urgency / Frequency (PUF) Patient Symptom Scale, urination diaries, analysis of which allowed to determine functional bladder capacity, urinary frequency and nocturia. Pain assessment was made with 10-point Visual Analogue Pain Scale (VAS). Functional efficacy was evaluated with urodynamic examination, which included cystometric bladder capacity, maximal urinary flow rate and residual volume rate. Treatment results were compared with such in 39 patients with IC/BPS without signs of bladder neck stenosis. Results. GRA score 2 had 96.5% and 72.4% in 1 and 3 months after bladder neck TUI, respectively. VAS, PUF Scale parameters, cystometric bladder capacity, maximal urinary flow rate, residual volume rate, urinary frequency and nocturia values also significantly improved after surgery. Conclusions. This prospective clinical study is the first, in which IC/BPS course in women with bladder neck stenosis was investigated. It was noticed, that in 1 month after bladder TUI in 96.5% of patients decreased severity of IC/BPS symptoms, there were no urinary tract infection and local complications. In addition, this effect lasted for 3 months after surgery in 72.4% of patients and for 6 months in 68.9% of patients.

Download Full-text

Urine cytokines as biomarkers for diagnosing interstitial cystitis/bladder pain syndrome and mapping its clinical characteristics

AJP Renal Physiology ◽

10.1152/ajprenal.00051.2020 ◽

2020 ◽

Vol 318 (6) ◽

pp. F1391-F1399 ◽

Cited By ~ 1

Author(s):

Yuan-Hong Jiang ◽

Jia-Fong Jhang ◽

Yung-Hsiang Hsu ◽

Han-Chen Ho ◽

Ya-Hui Wu ◽

...

Keyword(s):

Interstitial Cystitis ◽

Clinical Characteristics ◽

Area Under The Curve ◽

Pain Syndrome ◽

Bladder Capacity ◽

Bladder Pain Syndrome ◽

Bladder Pain ◽

Logistic Regression Models ◽

Cytokine Profiles ◽

Diagnostic Values

The objective of the present study was to investigate the diagnostic values of urine cytokines in patients with interstitial cystitis/bladder pain syndrome (IC/BPS) and to identify their correlations with clinical characteristics. Urine samples were collected from 127 patients with IC/BPS [European Society for the Study of Interstitial Cystitis (ESSIC) types 1 and 2] and 28 controls. Commercially available multiplex immunoassays (MILLIPLEX map kits) were used to analyze 31 targeted cytokines. Cytokine levels between patients with IC/BPS and controls were analyzed using ANOVA. Receiver-operating characteristic curves of each cytokine to distinguish IC/BPS from controls were generated for calculation of the area under the curve. Patients with IC/BPS had urine cytokine profiles that differed from those of controls. Between patients with ESSIC type 1 and 2 IC/BPS, urine cytokine profiles were also different. Among cytokines with high diagnostic values (i.e., area under the curve > 0.7) with respect to distinguish patients with ESSIC type 2 IC/BPS from controls, regulated upon activation, normal T cell expressed and presumably secreted (RANTES), macrophage inflammatory protein (MIP)-1β, and IL-8 were of higher sensitivity, whereas macrophage chemoattractant protein (MCP)-1, chemokine (C-X-C motif) ligand 10 (CXCL10), and eotaxin-1 were of higher specificity. In multivariate logistic regression models controlling for age, sex, body mass index, and diabetes mellitus, the urine cytokines with high diagnostic values (MCP-1, RANTES, CXCL10, IL-7, and eotaxin-1) remained statistically significant in differentiating IC/BPS and controls. MCP-1, CXCL10, eotaxin-1, and RANTES were positively correlated with glomerulation grade and negatively correlated with maximal bladder capacity. In conclusion, patients with IC/BPS had urine cytokine profiles that clearly differed from those of controls. Urine cytokines might be useful as biomarkers for diagnosing IC/BPS and mapping its clinical characteristics.

Download Full-text