Faculty Opinions recommendation of The importance of target binding kinetics for measuring target binding affinity in drug discovery: a case study from a CRF1 receptor antagonist program.

2019 ◽  
Author(s):  
Robert Copeland
Keyword(s):  
Drug Discovery ◽  
Receptor Antagonist ◽  
Binding Affinity ◽  
Binding Kinetics ◽  
Crf1 Receptor ◽  
Crf1 Receptor Antagonist ◽  
Target Binding

Discovery of 4-chloro-2-(2,4-dichloro-6-methylphenoxy)-1-methyl-7-(pentan-3-yl)-1H-benzimidazole, a novel CRF1 receptor antagonist

2017 ◽  
Vol 25 (5) ◽  
pp. 1556-1570 ◽  
Author(s):  
Michiyo Mochizuki ◽  
Takuto Kojima ◽  
Katsumi Kobayashi ◽  
Etsuo Kotani ◽  
Yuji Ishichi ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
Crf1 Receptor ◽  
Crf1 Receptor Antagonist

P.4.c.003 Preliminary evidence of efficacy of a CRF1 receptor antagonist in the 7.5% CO2 model of anxiety

2008 ◽  
Vol 18 ◽  
pp. S494 ◽  
Author(s):  
J.E. Bailey ◽  
A. Papadopoulos ◽  
A. Diaper ◽  
S. Phillips ◽  
M. Schmidt ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
Preliminary Evidence ◽  
Crf1 Receptor ◽  
Crf1 Receptor Antagonist

scholarly journals Effect of the CRF1-receptor antagonist pexacerfont on stress-induced eating and food craving

2016 ◽  
Vol 233 (23-24) ◽  
pp. 3921-3932 ◽  
Author(s):  
David H. Epstein ◽  
Ashley P. Kennedy ◽  
Melody Furnari ◽  
Markus Heilig ◽  
Yavin Shaham ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
Food Craving ◽  
Crf1 Receptor ◽  
Crf1 Receptor Antagonist

A novel water-soluble selective CRF1 receptor antagonist, NBI 35965, blunts stress-induced visceral hyperalgesia and colonic motor function in rats

2003 ◽  
Vol 985 (1) ◽  
pp. 32-42 ◽  
Author(s):  
Mulugeta Million ◽  
Dimitri E. Grigoriadis ◽  
Sue Sullivan ◽  
Paul D. Crowe ◽  
James A. McRoberts ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
Motor Function ◽  
Water Soluble ◽  
Visceral Hyperalgesia ◽  
Crf1 Receptor ◽  
Colonic Motor ◽  
Crf1 Receptor Antagonist
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