Faculty Opinions recommendation of Oliceridine, a G protein-selective ligand at the μ-opioid receptor, for the management of moderate to severe acute pain.

2021 ◽  
Author(s):  
Emmanuel Darcq
Keyword(s):  
G Protein ◽  
Opioid Receptor ◽  
Acute Pain ◽  
Selective Ligand ◽  
Μ Opioid Receptor

A First‐in‐Human Clinical Study With TRV734, an Orally Bioavailable G‐Protein–Biased Ligand at the μ‐Opioid Receptor

2019 ◽  
Vol 9 (2) ◽  
pp. 256-266 ◽  
Author(s):  
Ian E. James ◽  
Franck Skobieranda ◽  
David G. Soergel ◽  
Kimberly A. Ramos ◽  
Dennis Ruff ◽  
...  
Keyword(s):  
Clinical Study ◽  
G Protein ◽  
Opioid Receptor ◽  
Μ Opioid Receptor ◽  
Orally Bioavailable ◽  
Human Clinical Study

scholarly journals A G protein signaling-biased agonist at the μ-opioid receptor reverses morphine tolerance while preventing morphine withdrawal

2019 ◽  
Vol 45 (2) ◽  
pp. 416-425 ◽  
Author(s):  
Travis W. Grim ◽  
Cullen L. Schmid ◽  
Edward L. Stahl ◽  
Fani Pantouli ◽  
Jo-Hao Ho ◽  
...  
Keyword(s):  
G Protein ◽  
Opioid Receptor ◽  
Morphine Tolerance ◽  
Morphine Withdrawal ◽  
G Protein Signaling ◽  
Protein Signaling ◽  
Μ Opioid Receptor ◽  
Biased Agonist

scholarly journals Critical Assessment of G Protein-Biased Agonism at the μ-Opioid Receptor

2020 ◽  
Vol 41 (12) ◽  
pp. 947-959 ◽  
Author(s):  
Alexander Gillis ◽  
Andrea Kliewer ◽  
Eamonn Kelly ◽  
Graeme Henderson ◽  
Macdonald J. Christie ◽  
...  
Keyword(s):  
G Protein ◽  
Opioid Receptor ◽  
Critical Assessment ◽  
Biased Agonism ◽  
Μ Opioid Receptor

scholarly journals Pharmacological Characters of Oliceridine, a μ-Opioid Receptor G-Protein–Biased Ligand in Mice

2019 ◽  
Vol 129 (5) ◽  
pp. 1414-1421 ◽  
Author(s):  
De-Yong Liang ◽  
Wen-Wu Li ◽  
Chinwe Nwaneshiudu ◽  
Karen-Amanda Irvine ◽  
J. David Clark
Keyword(s):  
G Protein ◽  
Opioid Receptor ◽  
Μ Opioid Receptor
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