scholarly journals MARCADORES DA FUNÇÃO RENAL ATRAVÉS DA FILTRAÇÃO GLOMERULAR: UMA REVISÃO BIBLIOGRÁFICA

2021 ◽  
Vol 9 (209) ◽  
pp. 1-24
Author(s):  
Nucyla Beatriz Gomes dos Reis
Keyword(s):  
Glomerular Filtration Rate ◽  
Renal Disease ◽  
Glomerular Filtration ◽  
Renal Injury ◽  
Filtration Rate ◽  
Public Health Problem ◽  
Major Public Health Problem ◽  
Main Indicator ◽  
Early Markers ◽  
Dynamic Components

Currently, renal disease is a major public health problem that affects thousands of people in Brazil and worldwide, the kidneys are physiologically dynamic components of the system performing many functions, including the formation of urine, so it is paramount to early diagnosis the disease. The glomerular filtration rate is the main indicator of renal function in healthy subjects and patients. In this article the main markers of renal injury are assessed: creatinine, urea, proteinuria, cystatin, microalbuminuria. Early markers of renal damage are important because the glomerular filtration rate is reduced before the onset of symptoms or signs of renal disease are therefore important in the diagnosis of renal injury

scholarly journals CORRELATION OF THYROID HORMONES IN PATIENTS WITH CHRONIC KIDNEY DISEASE: AN OBSERVATIONAL STUDY

2021 ◽  
Vol 5 (6) ◽  
Author(s):  
Jyothi A Natikar ◽  
Asha G ◽  
Alapaty Shailaja
Keyword(s):  
Chronic Kidney Disease ◽  
Glomerular Filtration Rate ◽  
Kidney Disease ◽  
Renal Disease ◽  
Glomerular Filtration ◽  
Filtration Rate ◽  
Estimated Glomerular Filtration Rate ◽  
Public Health Problem ◽  
Endocrine Disturbances ◽  
Mdrd Formula

Introduction: Chronic kidney disease (CKD) is an international public health problem affecting about 5–10% of the population. It is the ninth leading cause of death. A trend towards increased incidence and prevalence is being reported worldwide with epidemic proportions in many countries. CKD is associated with variety of endocrine disturbances among which thyroid dysfunction is most common. This is probably due to reduce circulating hormone levels, altered binding of hormone to carrier protein or due to reduced peripheral metabolism of hormone. Materials and Methods: The study included 100 patients diagnosed with CKD. Both male and female patients aged between 30-70 years were selected for the study. Estimated Glomerular Filtration Rate (eGFR) was calculated using Modification of Diet in Renal Disease (MDRD) formula. Total T3, Total T4, TSH levels were measured by CLIA methodology. Results: Statistically significant alteration in TSH (p<0.01) values were seen with eGFR suggesting that alteration in the eGFR may lead to thyroid hormone resistance. Keywords: Chronic Kidney Disease(CKD), Estimated Glomerular Filtration Rate (eGFR), Modification of Diet in Renal Disease (MDRD)

DIAGNOSIS AND TREATMENT: ACUTE RENAL FAILURE

PEDIATRICS ◽  
1965 ◽  
Vol 35 (3) ◽  
pp. 478-481
Author(s):  
Malcolm A. Holliday
Keyword(s):  
Renal Failure ◽  
Acute Renal Failure ◽  
Glomerular Filtration Rate ◽  
Renal Disease ◽  
Glomerular Filtration ◽  
Filtration Rate ◽  
Obstructive Uropathy ◽  
Urine Flow ◽  
Water Restriction ◽  
Plasma Electrolyte

ACUTE RENAL FAILURE is an uncommon emergency which faces pediatricians. It is usually easy to recognize. The management in the early phase is critical to the survival potential of the patient. The purpose of this review is to cite the causes, characteristics, and principally the management of acute renal failure. Renal failure is defined as a state in which there is not sufficient kidney function to prevent the development of severe uremia or to maintain plasma electrolyte values in a range compatible with ordinary activities. Clinically the condition is associated with mental confusion, stupor, and frequently convulsions. Persistent hiccoughs, irregular respirations, and muscle cramps also may occur. Usually though not always, there is obvious oliguria. Since urine flow is ordinarily but 0.2-2,0% of glomerular filtration rate, and since glomerular filtration rate reduction to 5-10% may be associated with uremia, it is possible to have renal failure without oliguria. It is also possible to have physiological oliguria (&lt; 300 ml per square meter) in response to rigid water restriction that is not related to renal failure. Hence, the term must be defined in terms of its effect on plasma composition rather than in terms of urine flow. The presence of certain clinical conditions known to result in acute renal failure should alert the physician. These include: nephrotoxie agents; hemoglobinuria or myoglobinuria; shock with anoxic damage; acute, diffuse renal disease; acute dehydration in patients with chronic advanced renal disease; and acute obstructive uropathy. Nephrotoxic agents, hemoglobinuria, and shock all result in acute tubular necrosis, and recovery depends upon the capacity of the nephron to regenerate on an intact basement membrane.

scholarly journals Matching Human Unilateral AKI, a Reverse Translational Approach to Investigate Kidney Recovery after Ischemia

2019 ◽  
Vol 30 (6) ◽  
pp. 990-1005 ◽  
Author(s):  
Danielle E. Soranno ◽  
Hyo-Wook Gil ◽  
Lara Kirkbride-Romeo ◽  
Christopher Altmann ◽  
John R. Montford ◽  
...  
Keyword(s):  
Glomerular Filtration Rate ◽  
Glomerular Filtration ◽  
Renal Injury ◽  
Filtration Rate ◽  
Human Study ◽  
Renal Ischemia ◽  
Research Approach ◽  
Urine Biomarkers ◽  
Injured Kidney

BackgroundThe duration of renal ischemia that is associated with (or leads to) renal injury in patients is uncertain, and a reverse translational research approach has been proposed to improve animal models of AKI to facilitate clinical translatability. We developed a two murine models of unilateral renal ischemia to match a recently published human study that investigated renal injury after unilateral renal ischemia during partial nephrectomy.MethodsEight 10-week-old C57BL/6 male mice underwent left UiAKI or sham procedure, with or without intra-operative ice packs. Functional, histological, and biomarker outcomes were followed at 2, 6 and 24 hours, or 14 or 28 days later. The 14 and 28 day cohorts were duplicated such that contralateral nephrectomy could be performed 3 days prior to sacrifice with functional measurements obtained to isolate the glomerular filtration rate of the injured kidney.ResultsThe short-term outcomes correlated with the human study findings with urine and serum biomarkers of injury peaking around 24 hours and then normalizing, and reassuring immediate histological outcomes. Functional and histological outcomes at the later time-points (14 and 28 days) demonstrate an increase in fibrosis markers, and a reduction in glomerular filtration rate in the injured kidney, corresponding to the duration of ischemia, while serum and urine biomarkers remained reassuring.ConclusionsOur findings suggest that clinically available biomarkers of renal function are falsely reassuring against long-term injury following UiAKI, and that the duration of ischemia correlates with impaired function and increased fibrosis.

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