Clinical side effects of antituberculosis drugs

A 60-year-old male patient on maintenance hemodialysis was started on antituberculosis therapy with isoniazid, rifampin, ethambutol, and pyrazinamide for pulmonary tuberculosis. After 4 weeks of therapy, he developed pruritic lesions in the extremities followed by exfoliation. The lesions progressively spread over the entire body. Lesions resolved after withdrawal of antituberculosis medications and administration of oral corticosteroids and antihistamines. After 2 weeks antituberculosis drugs were rechallenged one at a time. Administration of oral pyrazinamide resulted in reappearance of symptoms (pruritis and erythema) within 48 hours. Pyrazinamide was substituted with ofloxacin while other three drugs were restarted without any side effects. The case illustrates a rare but potentially dangerous complication of pyrazinamide therapy.

Download Full-text

The Side Effects and Interactions of Antituberculosis Drugs

CHEST Journal ◽

10.1378/chest.76.6.782 ◽

1979 ◽

Vol 76 (6) ◽

pp. 782-784 ◽

Cited By ~ 10

Author(s):

Whitney W. Addington

Keyword(s):

Side Effects ◽

Antituberculosis Drugs

Download Full-text

Clinical side effects of antituberculosis drugs

Research on Pharmacology ◽

10.35534/per.20200821ceshi ◽

2019 ◽

Vol 1 (2) ◽

pp. 39-44

Author(s):

Zhao Ying

Keyword(s):

Side Effects ◽

Antituberculosis Drugs

Download Full-text

Isoniazid- and rifampicin-induced thrombocytopenia

Multidisciplinary Respiratory Medicine ◽

10.4081/mrm.2013.482 ◽

2013 ◽

Vol 8 ◽

Author(s):

Fatih Yakar ◽

Namşan Yildiz ◽

Aysun Yakar ◽

Zeki Kılıçaslan

Keyword(s):

Side Effects ◽

Pulmonary Tuberculosis ◽

Drug Treatment ◽

Side Effect ◽

Drug Regimen ◽

Current Case ◽

Antituberculosis Drugs ◽

Thrombocyte Count ◽

Smear Positive Pulmonary Tuberculosis ◽

Further Development

Treatment of tuberculosis has many side effects. Thrombocytopenia is a serious side effect of such treatment and occurs mostly due to rifampicin (RIF). There are very few reported cases of thrombocytopenia due to isoniazid (INH). An 18-year-old female patient was diagnosed with smear-positive pulmonary tuberculosis. A four-drug regimen [INH, RIF, ethambutol (EMB), and pyrazinamide (PZA)] was given. After the development of thrombocytopenia, the drug treatment was stopped, and a thrombocyte suspension was given until a normal thrombocyte count was obtained. After several start-stop trials, first INH and then RIF were identified as the possible causes of thrombocytopenia and were removed from the regimen. The patient was treated with EMB, streptomycin, PZA, and moxifloxacin with no further development of thrombocytopenia. The current case shows that antituberculosis drugs other than RIF and PZA may be responsible for the development of thrombocytopenia.

Download Full-text