scholarly journals NEW PROGNOSTIC METHOD FOR ESTIMATION OF LIPID DISTRESS SYNDROME DEVELOPMENT IN PATIENTS WITH CHRONIC HEPATITIS C

2019 ◽  
Vol 4 (1) ◽  
pp. 16-19
Author(s):  
Dmitrii Yu. Konstantinov ◽  
German V. Nedugov ◽  
Larisa L. Popova ◽  
Elena A. Konstantinova
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Viral Hepatitis ◽  
Antiviral Therapy ◽  
Chronic Hepatitis C ◽  
Distress Syndrome ◽  
Function Analysis ◽  
Chronic Viral Hepatitis ◽  
Viral Hepatitis C ◽  
Chronic Viral Hepatitis C

Objectives - to work out a prognostic method, based on clinical and laboratory data, which can predict the development of lipid distress syndrome in patients with chronic viral hepatitis C. Material and methods. We studied the outcomes of chronic viral hepatitis C with respect to development of lipid distress syndrome in 267 patients who did not receive antiviral therapy during the observation period lasting for 1 to 7 years. Results. Discriminant function analysis of the data acquired after examination of 167 patients helped us to work out a discriminative model of predicting the development of lipid distress syndrome in patients with chronic viral hepatitis C in the absence of antiviral therapy. Crosschecking of prediction accuracy was carried out on the data of examination of other 100 patients. Conclusion. The designed technique for predicting the development of lipid distress syndrome in patients with chronic hepatitis C is characterized by point estimates of sensitivity and prognostic value of the negative result equal to 100%.

scholarly journals Features of ophthalmic disorders in patients with chronic viral hepatitis C before and after antiviral treatment

2012 ◽  
Vol 93 (6) ◽  
pp. 989-991
Author(s):  
G E Akberova ◽  
F R Saifullina ◽  
I M Khaertynova
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Viral Hepatitis ◽  
Color Vision ◽  
Chronic Hepatitis C ◽  
Antiviral Treatment ◽  
Chronic Viral Hepatitis ◽  
Viral Hepatitis C ◽  
Before And After ◽  
Chronic Viral Hepatitis C

Aim. To study the features of ophthalmic disorders in patients with chronic viral hepatitis C before and after antiviral treatment. Methods. 40 patients (80 eyes) with chronic hepatitis C were observed (the main group). The control group consisted of 20 healthy subjects (40 eyes). To diagnose chronic hepatitis C infection and to assess liver damage a set of clinical, epidemiological and laboratory tests was performed. All patients underwent liver ultrasonography. The diagnosis of chronic hepatitis C was set up according to presence of immunoglobulin M and G to hepatitis C virus and presence of viral RNA on polymerase chain reaction in peripheral blood. Along with standard opthalmic examination, visual field testing using the white and chromatic light and visual lability testing were performed. Results. Color vision impairments were diagnosed in 50% of patients with chronic hepatitis C, with decreased visual lability for the red and green colors in 100% of cases. After 6 months of antiviral treatment restoration of visual function was observed. The durability of visual impairments in patients with chronic hepatitis C depended on the severity of the disease. Conclusion. In patients with chronic hepatitis C with the short term of the disease ophthalmic disorders such as decreased peripheral vision, color vision impairments, decreased visual lability are reversible.

scholarly journals Prediction of the development of lipid distress syndrome in patients with a sustained response to antiviral therapy of chronic hepatitis C

2020 ◽  
Vol 19 (5-6) ◽  
pp. 81-85
Author(s):  
Dmitry Yu. Konstantinov ◽  
Tatiana V. Konnova
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Antiviral Therapy ◽  
Chronic Hepatitis C ◽  
Distress Syndrome ◽  
Laboratory Data ◽  
Chronic Viral Hepatitis ◽  
Sustained Response ◽  
Viral Hepatitis C ◽  
Discriminative Model

Aim. The purpose of the article is to devise the method for predicting the development of lipid distress syndrome in patients with a sustained response to antiviral therapy of chronic viral hepatitis C on the basis of clinical and laboratory data. Materials and methods. The outcomes of lipid distress syndrome were studied in 235 patients with a sustained virological response to antiviral therapy of chronic hepatitis C during the follow-up period lasting from 1 to 10 years. Results. From the perspective of the discriminative analysis of the data of the complex examination of 135 patients, we developed a discriminative model of predicting the development of lipid distress syndrome in patients with a sustained response to antiviral therapy of chronic hepatitis C. The cross-checking of the accuracy of prediction was carried out by the examination of other 100 patients. Conclusion. Sensitivity, specificity, prognostic value of positive and negative prognostic results and the accuracy index of the developed discriminative model for predicting the development of lipid distress syndrome are equal to 100%.

scholarly journals Significance of iron reduction for the therapy of chronic hepatitis C

2005 ◽  
Vol 62 (2) ◽  
pp. 161-164 ◽  
Author(s):  
Darko Nozic ◽  
Bela Balint ◽  
Nebojsa Stankovic ◽  
Jovan Dimitrijevic ◽  
Gorana Neskovic
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Iron Overload ◽  
Antiviral Therapy ◽  
Chronic Hepatitis C ◽  
Iron Reduction ◽  
Elevated Serum ◽  
Chronic Viral Hepatitis ◽  
Viral Hepatitis C ◽  
Iron Deposits

Background. It has been established that many patients with chronic hepatitis C have elevated serum iron, feritin levels and iron deposits in the liver. Therefore, the liver damage due to hepatitis C virus may be aggravated with iron overload. In many studies higher levels of iron in the blood and the liver were connected with the decreased response to interferon-alfa therapy for chronic viral hepatitis C. Recent introduction of pegylated interferons plus ribavirin has improved the therapeutic response, so it is now possible to cure more than 50% of the patients. Case report. Three patients with chronic hepatitis C and iron overload were presented. Iron reduction therapy using phlebotomy or eritrocytapheresis with plasmapheresis was done at different times in regard to specific antiviral therapy or as a sole therapy. Conclusion. It has been shown that iron reduction, sole or combined with antiviral therapy, led to the deacreased aminotransferase serum activity and might have slow down the evolution of chronic hepatitis C viral infection.

Antiviral therapy of liver cirrhosis in the outcome of chronic viral hepatitis C

2021 ◽  
pp. 89-97
Author(s):  
ANARKAN SHABOLOTOVNA TASHPOLOTOVA ◽  
GULMIRA SAIBILDAEVNA SURANBAEVA ◽  
MYSKAL MAMAZIAEVNA ABDIKERIMOVA ◽  
ALTYNAI BORUBAEVNA MYRZAKULOVA ◽  
ANARA SHAMSHIDINOVNA DJUMAGULOVA ◽  
...  
Keyword(s):  
Liver Cirrhosis ◽  
Hepatitis C ◽  
Viral Hepatitis ◽  
Antiviral Therapy ◽  
Chronic Viral Hepatitis ◽  
Viral Hepatitis C ◽  
Chronic Viral Hepatitis C

Prognosis of the development of lipid distress syndrome in chronic viral hepatitis C

2018 ◽  
Vol 16 (4) ◽  
pp. 34-37 ◽  
Author(s):  
D.Yu. Konstantinov ◽  
◽  
G.V. Nedugov ◽  
A.A. Suzdaltsev ◽  
E.A. Konstantinova ◽  
...  
Keyword(s):  
Hepatitis C ◽  
Viral Hepatitis ◽  
Distress Syndrome ◽  
Chronic Viral Hepatitis ◽  
Viral Hepatitis C ◽  
Chronic Viral Hepatitis C

scholarly journals NEW PERSPECTIVES OF PERSONALIZED THERAPY OF CHRONIC HEPATITIS C

2013 ◽  
Vol 18 (3) ◽  
pp. 27-36
Author(s):  
G. V. Sapronov ◽  
L. I. Nikolaeva
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Viral Hepatitis ◽  
Protease Inhibitors ◽  
Mechanism Of Action ◽  
Chronic Viral Hepatitis ◽  
Pharmacological Agents ◽  
Viral Hepatitis C ◽  
Molecular Mechanism Of Action ◽  
Chronic Viral Hepatitis C

The aim of this review - to analyze the possibilities of traditional therapy and opening new perspectives and approaches to personalized theraру of patients with chronic viral hepatitis C. There are considered the viral and patien tfactors that have an mpact on the efficacy of theтру with interferon-a2 and ribavirin. There are presented data on the molecular mechanism of action of these drugs preparations. There are considered new antiviral drugs (protease inhibitors) and pharmacological agents being under development and targeted to viral polymerase andprotein NS5A.

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