Significance of iron reduction for the therapy of chronic hepatitis C

Background. It has been established that many patients with chronic hepatitis C have elevated serum iron, feritin levels and iron deposits in the liver. Therefore, the liver damage due to hepatitis C virus may be aggravated with iron overload. In many studies higher levels of iron in the blood and the liver were connected with the decreased response to interferon-alfa therapy for chronic viral hepatitis C. Recent introduction of pegylated interferons plus ribavirin has improved the therapeutic response, so it is now possible to cure more than 50% of the patients. Case report. Three patients with chronic hepatitis C and iron overload were presented. Iron reduction therapy using phlebotomy or eritrocytapheresis with plasmapheresis was done at different times in regard to specific antiviral therapy or as a sole therapy. Conclusion. It has been shown that iron reduction, sole or combined with antiviral therapy, led to the deacreased aminotransferase serum activity and might have slow down the evolution of chronic hepatitis C viral infection.

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Prediction of the development of lipid distress syndrome in patients with a sustained response to antiviral therapy of chronic hepatitis C

Aspirantskiy Vestnik Povolzhiya ◽

10.17816/2072-2354.2019.19.3.81-85 ◽

2020 ◽

Vol 19 (5-6) ◽

pp. 81-85

Author(s):

Dmitry Yu. Konstantinov ◽

Tatiana V. Konnova

Keyword(s):

Chronic Hepatitis ◽

Hepatitis C ◽

Antiviral Therapy ◽

Chronic Hepatitis C ◽

Distress Syndrome ◽

Laboratory Data ◽

Chronic Viral Hepatitis ◽

Sustained Response ◽

Viral Hepatitis C ◽

Discriminative Model

Aim. The purpose of the article is to devise the method for predicting the development of lipid distress syndrome in patients with a sustained response to antiviral therapy of chronic viral hepatitis C on the basis of clinical and laboratory data. Materials and methods. The outcomes of lipid distress syndrome were studied in 235 patients with a sustained virological response to antiviral therapy of chronic hepatitis C during the follow-up period lasting from 1 to 10 years. Results. From the perspective of the discriminative analysis of the data of the complex examination of 135 patients, we developed a discriminative model of predicting the development of lipid distress syndrome in patients with a sustained response to antiviral therapy of chronic hepatitis C. The cross-checking of the accuracy of prediction was carried out by the examination of other 100 patients. Conclusion. Sensitivity, specificity, prognostic value of positive and negative prognostic results and the accuracy index of the developed discriminative model for predicting the development of lipid distress syndrome are equal to 100%.

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NEW PROGNOSTIC METHOD FOR ESTIMATION OF LIPID DISTRESS SYNDROME DEVELOPMENT IN PATIENTS WITH CHRONIC HEPATITIS C

Science and Innovations in Medicine ◽

10.35693/2500-1388-2019-4-1-16-19 ◽

2019 ◽

Vol 4 (1) ◽

pp. 16-19

Author(s):

Dmitrii Yu. Konstantinov ◽

German V. Nedugov ◽

Larisa L. Popova ◽

Elena A. Konstantinova

Keyword(s):

Chronic Hepatitis ◽

Hepatitis C ◽

Viral Hepatitis ◽

Antiviral Therapy ◽

Chronic Hepatitis C ◽

Distress Syndrome ◽

Function Analysis ◽

Chronic Viral Hepatitis ◽

Viral Hepatitis C ◽

Chronic Viral Hepatitis C

Objectives - to work out a prognostic method, based on clinical and laboratory data, which can predict the development of lipid distress syndrome in patients with chronic viral hepatitis C. Material and methods. We studied the outcomes of chronic viral hepatitis C with respect to development of lipid distress syndrome in 267 patients who did not receive antiviral therapy during the observation period lasting for 1 to 7 years. Results. Discriminant function analysis of the data acquired after examination of 167 patients helped us to work out a discriminative model of predicting the development of lipid distress syndrome in patients with chronic viral hepatitis C in the absence of antiviral therapy. Crosschecking of prediction accuracy was carried out on the data of examination of other 100 patients. Conclusion. The designed technique for predicting the development of lipid distress syndrome in patients with chronic hepatitis C is characterized by point estimates of sensitivity and prognostic value of the negative result equal to 100%.

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THE PATHOGENETIC SIGNIFICANCE OF GENE IL28B POLYMORPHISMS AT SITES RS12979860 AND RS8099917 IN THE DEVELOPMENT OF CHRONIC VIRAL HEPATITIS C IN PATIENTS OF THE SOUTH-EASTERN REGION OF BELARUS

Health and Ecology Issues ◽

10.51523/2708-6011.2016-13-4-7 ◽

2016 ◽

pp. 32-36

Author(s):

Z. V. Shuliak ◽

E. I. Mikhailova

Keyword(s):

Chronic Hepatitis ◽

Hepatitis C ◽

Chronic Hepatitis C ◽

Chronic Viral Hepatitis ◽

Eastern Region ◽

Acute Viral Infection ◽

Viral Hepatitis C ◽

Allele Specific ◽

Polymerase Chain

To study the role of IL28B gene polymorphisms in the development of chronic hepatitis C, we have determined polymorphic types of the gene at sites rs12979860 and rs8099917 using allele-specific polymerase chain reaction with real-time product detection in 21 patients with this disease. We have found the association of chronic hepatitis C with the presence of unfavorable TT genotype of gene IL28B polymorphism rs12979860, which can be regarded as a predictor of the development of this pathology. Favorable genotypes of CC rs12979860 and TT polymorphism of rs8099917 of gene IL28B are more common in healthy individuals and they are associated with higher activity of the inflammatory process in patients with chronic hepatitis C. Therefore, gene IL28B polymorphisms can affect not only the outcome of an acute viral infection but also the further course of chronic hepatitis C.

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Insulin Resistance in Patients with Chronic Hepatitis C

Macedonian Medical Review ◽

10.1515/mmr-2016-0018 ◽

2016 ◽

Vol 70 (2) ◽

pp. 93-98

Author(s):

Beti Todorovska ◽

Viktorija Caloska-Ivanova ◽

Magdalena Dimitrova-Genadieva ◽

Elena Curakova ◽

Nenad Joksimovic

Keyword(s):

Insulin Resistance ◽

Chronic Hepatitis ◽

Viral Load ◽

Hepatitis C ◽

Chronic Hepatitis C ◽

Liver Steatosis ◽

Chronic Viral Hepatitis ◽

Cross Sectional ◽

Viral Hepatitis C ◽

Treatment Naïve

Abstract Introduction. Insulin resistance is the most common extrahepatic manifestation associated with hepatitis C virus, which leads to developing more pronounced fibrosis and liver steatosis. The aim of the study was to assess the prevalence of insulin resistance in non-diabetic, treatment naive patients with chronic hepatitis C and to analyze the relation of insulin resistance with genotype, viral load, gender, age, laboratory parameters, inflammatory and fibrotic changes in the liver, body mass index (BMI) and the presence of steatosis. Methods. In this cross sectional study, 224 patients with hepatitis C viral infection were included. The patients were divided into two groups. The first group was with no insulin resistance and the second one with present insulin resistance. They were compared in terms of genotype, viral load, gender, age, inflammatory and fibrotic changes in the liver, BMI and liver steatosis. Results. Insulin resistance was present in 45.5% of patients. The following factors were associated with insulin resistance: age (p=0.0022), inflammatory and fibrotic changes in the liver (p=0.001, p=0.006, respectively), steatosis (p=0.015) and transaminase activities (for AST, p=0,002, for ALT, p=0.001). Conclusion. In the Republic of Macedonia, a high percent of 45.5% among non-diabetic and treatment naïve patients with chronic viral hepatitis C, had insulin resistance. Insulin resistance was more prevalent in older patients, in those with more pronounced inflammatory and fibrotic changes in the liver, in patients with steatosis and in those with higher transaminase activity.

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Features of ophthalmic disorders in patients with chronic viral hepatitis C before and after antiviral treatment

Kazan medical journal ◽

10.17816/kmj2127 ◽

2012 ◽

Vol 93 (6) ◽

pp. 989-991

Author(s):

G E Akberova ◽

F R Saifullina ◽

I M Khaertynova

Keyword(s):

Chronic Hepatitis ◽

Hepatitis C ◽

Viral Hepatitis ◽

Color Vision ◽

Chronic Hepatitis C ◽

Antiviral Treatment ◽

Chronic Viral Hepatitis ◽

Viral Hepatitis C ◽

Before And After ◽

Chronic Viral Hepatitis C

Aim. To study the features of ophthalmic disorders in patients with chronic viral hepatitis C before and after antiviral treatment. Methods. 40 patients (80 eyes) with chronic hepatitis C were observed (the main group). The control group consisted of 20 healthy subjects (40 eyes). To diagnose chronic hepatitis C infection and to assess liver damage a set of clinical, epidemiological and laboratory tests was performed. All patients underwent liver ultrasonography. The diagnosis of chronic hepatitis C was set up according to presence of immunoglobulin M and G to hepatitis C virus and presence of viral RNA on polymerase chain reaction in peripheral blood. Along with standard opthalmic examination, visual field testing using the white and chromatic light and visual lability testing were performed. Results. Color vision impairments were diagnosed in 50% of patients with chronic hepatitis C, with decreased visual lability for the red and green colors in 100% of cases. After 6 months of antiviral treatment restoration of visual function was observed. The durability of visual impairments in patients with chronic hepatitis C depended on the severity of the disease. Conclusion. In patients with chronic hepatitis C with the short term of the disease ophthalmic disorders such as decreased peripheral vision, color vision impairments, decreased visual lability are reversible.

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Interleukin 28B Gene Polymorphism and Association with Chronic Hepatitis C Therapy Results in Latvia

Hepatitis Research and Treatment ◽

10.1155/2012/324090 ◽

2012 ◽

Vol 2012 ◽

pp. 1-4 ◽

Cited By ~ 4

Author(s):

Ieva Tolmane ◽

Baiba Rozentale ◽

Jazeps Keiss ◽

Ludmila Ivancenko ◽

Nadezda Subnikova ◽

...

Keyword(s):

Chronic Hepatitis ◽

Hepatitis C ◽

Gene Polymorphism ◽

Chronic Hepatitis C ◽

Strong Predictor ◽

Standard Of Care ◽

Chronic Viral Hepatitis ◽

Treatment Result ◽

Interleukin 28B ◽

Viral Hepatitis C

Introduction. With the standard treatment of chronic hepatitis C, sustained virological response (SVR) can be achieved only in half of all patients. Interleukin-28B appears to be involved in the control of HCV infection, and the genetic polymorphism of the encoding IL-28B gene may determine the efficacy of clearance of HCV. The aim of this paper was to detect IL-28B gene polymorphism in Latvia and to analyze therapy results. This is the first study on IL-28B gene polymorphism in Latvia. Material and Methods. There were 159 chronic viral hepatitis C patients included in the study. In order to detect IL-28B gene polymorphism, we used molecular biology techniques and methods: classical DNA separation, amplification by PCR, and standard sequencing. Genotype was defined as CC, CT, TC, or TT type. 142 patients were treated with the standard of care treatment. Results were analyzed according to IL-28B polymorphism. Results. There were 53 patients (33%) with CC genotype, 84 patients (53%) with CT/TC genotype, and 22 patients (14%) with TT genotype. 34 patients (74%) in CC genotype subgroup achieved SVR versus 50 patients (52%) in non-CC subgroups. In patients with genotype 1, SVR was achieved in 16 patients (84%) in CC subgroup versus 30 patients (47.6%) in non-CC subgroups, P=0.007. Conclusions. The most common genotype of IL28B in Latvia is CT/TC, with an incidence of 53%. Patients with CC genotype achieved SVR more often than CT or TT subgroups. IL28B gene polymorphism therefore is a strong predictor of treatment result.

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CHRONIC VIRAL HEPATITIS C INFECTION;

The Professional Medical Journal ◽

10.29309/tpmj/2013.20.03.827 ◽

2013 ◽

Vol 20 (03) ◽

pp. 374-380

Author(s):

MUHAMMAD SOHAIL ANJUM ◽

SHAHID MAQBOOL ◽

MUHAMMAD HAMID SAEED ◽

Tanveer Hussain ◽

Naila Kalsoom

Keyword(s):

Chronic Hepatitis ◽

Blood Glucose ◽

Hepatitis C ◽

Chronic Hepatitis C ◽

Close Association ◽

Fasting Blood Glucose ◽

Chronic Viral Hepatitis ◽

Outpatient Department ◽

Hepatitis C Infection ◽

Viral Hepatitis C

Objective: The objective of the study was to measure the frequency of impaired glucose tolerance (IGT) in patients havingchronic hepatitis C at medical outpatient department (OPD) of Allied hospital Faisalabad. Sample technique: Non probability consecutivesampling. Duration of study: Duration of study was 6 months with first patient enrolled on 3.02.2010 and last patient enrolled on 07-08-2010. Setting: Medical (OPD) Outpatient Department of Allied Hospital, Faisalabad. Subjects: 375 patients with chronic hepatitis C,coming in Medical OPD of Allied hospital Faisalabad were enrolled. Methods: 375 patients diagnosed as having chronic hepatitis Ccoming in Medical OPD of Allied hospital Faisalabad, were included in the study. Fasting and two hours after glucose load blood samplewere collected in sterilized syringes and was tested for fasting blood glucose (FBS) and random blood glucose level (RBS). Results: Inthis study 375 patients having HCV positive on Elisa were enrolled. Out of 375 patients with chronic hepatitis C, 143 (38.1%) were foundto have IGT while 232 (61.9%) were having no IGT. There was significant association between chronic hepatitis C and development of IGT.Conclusions: It is concluded that there is close association in the development of IGT in patients with chronic hepatitis C.

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Serum Alpha-fetoprotein Levels and Response to Direct Antiviral Therapy in Patients with Chronic Hepatitis C: Real-world Results from 1716 Patients in Egypt

Endocrine Metabolic & Immune Disorders - Drug Targets ◽

10.2174/1871530319666190204154830 ◽

2019 ◽

Vol 19 (7) ◽

pp. 1005-1011

Author(s):

Rehab Badawi ◽

Mohamed Alboraie ◽

Sherief Abd-Elsalam ◽

Mohamed Z. Abourahma ◽

Haidi K. Ramadan ◽

...

Keyword(s):

Chronic Hepatitis ◽

Hepatitis C ◽

Antiviral Therapy ◽

Chronic Hepatitis C ◽

Univariate Analysis ◽

Elevated Serum ◽

Multivariate Logistic Regression Analysis ◽

P Value ◽

Significant Variable ◽

Chronic Hcv

Background &Aims: Direct Antiretroviral Agents (DAAs), sofosbuvir-based therapies, have opened a new era in the treatment of chronic HCV infection. The aim of the study was to investigate the potential use of baseline and in serial serum, AFP levels as a predictor for response to DAAs in patients with Chronic Hepatitis C. Methods: This multicenter observational study was carried out on 1716 chronic hepatitis C virusinfected patients who received direct anti-viral drugs for 12 weeks. The primary end point was sustained virological response at 12 weeks after the end of treatment determined by quantitative PCR for HCV RNA. Serum AFP was quantitatively assessed at baseline then after 12week after stoppage of treatment (SVR12). Results: SVR12 rate was 97.8%. Elevated serum AFP was significantly higher in non -SVR group p value (<0.001). There was a significantly marked decrease in AFP after treatment in comparison to pretreatment values. The multivariate logistic regression analysis on the resulting significant variable from the univariate analysis revealed that only AFP was significantly related to the response to direct antiviral therapy in patients with chronic hepatitis C with p <0.001, OR 1.10 (95% CI 1.07:1.12). Other sociodemographic (e.g. Age, gender, BMI, ..) or laboratory factors (Hb, ANC, WBCs, …) did not show any significant association with the patients’ response to treatment. Conclusion: Serum AFP levels were a predictor for response in patients with chronic HCV with the administration of direct antiviral drugs.

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