scholarly journals NEW PERSPECTIVES OF PERSONALIZED THERAPY OF CHRONIC HEPATITIS C

2013 ◽  
Vol 18 (3) ◽  
pp. 27-36
Author(s):  
G. V. Sapronov ◽  
L. I. Nikolaeva
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Viral Hepatitis ◽  
Protease Inhibitors ◽  
Mechanism Of Action ◽  
Chronic Viral Hepatitis ◽  
Pharmacological Agents ◽  
Viral Hepatitis C ◽  
Molecular Mechanism Of Action ◽  
Chronic Viral Hepatitis C

The aim of this review - to analyze the possibilities of traditional therapy and opening new perspectives and approaches to personalized theraру of patients with chronic viral hepatitis C. There are considered the viral and patien tfactors that have an mpact on the efficacy of theтру with interferon-a2 and ribavirin. There are presented data on the molecular mechanism of action of these drugs preparations. There are considered new antiviral drugs (protease inhibitors) and pharmacological agents being under development and targeted to viral polymerase andprotein NS5A.

scholarly journals Features of ophthalmic disorders in patients with chronic viral hepatitis C before and after antiviral treatment

2012 ◽  
Vol 93 (6) ◽  
pp. 989-991
Author(s):  
G E Akberova ◽  
F R Saifullina ◽  
I M Khaertynova
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Viral Hepatitis ◽  
Color Vision ◽  
Chronic Hepatitis C ◽  
Antiviral Treatment ◽  
Chronic Viral Hepatitis ◽  
Viral Hepatitis C ◽  
Before And After ◽  
Chronic Viral Hepatitis C

Aim. To study the features of ophthalmic disorders in patients with chronic viral hepatitis C before and after antiviral treatment. Methods. 40 patients (80 eyes) with chronic hepatitis C were observed (the main group). The control group consisted of 20 healthy subjects (40 eyes). To diagnose chronic hepatitis C infection and to assess liver damage a set of clinical, epidemiological and laboratory tests was performed. All patients underwent liver ultrasonography. The diagnosis of chronic hepatitis C was set up according to presence of immunoglobulin M and G to hepatitis C virus and presence of viral RNA on polymerase chain reaction in peripheral blood. Along with standard opthalmic examination, visual field testing using the white and chromatic light and visual lability testing were performed. Results. Color vision impairments were diagnosed in 50% of patients with chronic hepatitis C, with decreased visual lability for the red and green colors in 100% of cases. After 6 months of antiviral treatment restoration of visual function was observed. The durability of visual impairments in patients with chronic hepatitis C depended on the severity of the disease. Conclusion. In patients with chronic hepatitis C with the short term of the disease ophthalmic disorders such as decreased peripheral vision, color vision impairments, decreased visual lability are reversible.

scholarly journals NEW PROGNOSTIC METHOD FOR ESTIMATION OF LIPID DISTRESS SYNDROME DEVELOPMENT IN PATIENTS WITH CHRONIC HEPATITIS C

2019 ◽  
Vol 4 (1) ◽  
pp. 16-19
Author(s):  
Dmitrii Yu. Konstantinov ◽  
German V. Nedugov ◽  
Larisa L. Popova ◽  
Elena A. Konstantinova
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Viral Hepatitis ◽  
Antiviral Therapy ◽  
Chronic Hepatitis C ◽  
Distress Syndrome ◽  
Function Analysis ◽  
Chronic Viral Hepatitis ◽  
Viral Hepatitis C ◽  
Chronic Viral Hepatitis C

Objectives - to work out a prognostic method, based on clinical and laboratory data, which can predict the development of lipid distress syndrome in patients with chronic viral hepatitis C. Material and methods. We studied the outcomes of chronic viral hepatitis C with respect to development of lipid distress syndrome in 267 patients who did not receive antiviral therapy during the observation period lasting for 1 to 7 years. Results. Discriminant function analysis of the data acquired after examination of 167 patients helped us to work out a discriminative model of predicting the development of lipid distress syndrome in patients with chronic viral hepatitis C in the absence of antiviral therapy. Crosschecking of prediction accuracy was carried out on the data of examination of other 100 patients. Conclusion. The designed technique for predicting the development of lipid distress syndrome in patients with chronic hepatitis C is characterized by point estimates of sensitivity and prognostic value of the negative result equal to 100%.

scholarly journals Assessment of adherence to chronic viral hepatitis C treatment in Romania: an open, single center, prospective study

2016 ◽  
Vol 2 (2) ◽  
pp. 59-68
Author(s):  
Anca Streinu-Cercel ◽  
Maria-Magdalena Moțoi ◽  
Alina Cristina Neguț ◽  
Luminița Bradu ◽  
Daniela Manolache ◽  
...  
Keyword(s):  
Hepatitis C ◽  
Prospective Study ◽  
Viral Hepatitis ◽  
Chronic Viral Hepatitis ◽  
Single Center ◽  
Hepatitis C Treatment ◽  
Viral Hepatitis C ◽  
Chronic Viral Hepatitis C

Epidemiological, demographic and clinical data on chronic viral hepatitis C in Tuscany

2018 ◽  
Vol 35 (4) ◽  
pp. 661-666 ◽  
Author(s):  
Cristina Stasi ◽  
Caterina Silvestri ◽  
Roberto Berni ◽  
Maurizia Rossana Brunetto ◽  
Anna Linda Zignego ◽  
...  
Keyword(s):  
Hepatitis C ◽  
Viral Hepatitis ◽  
Clinical Data ◽  
Chronic Viral Hepatitis ◽  
Viral Hepatitis C ◽  
Chronic Viral Hepatitis C

Chronic viral hepatitis C. Approach to therapy

2021 ◽  
Vol 87 (1) ◽  
pp. 37-41
Author(s):  
T. Ye. Makarova ◽  
◽  
N.N. Dudareva ◽  
N.N. Poletaeva ◽  
E.A. Medvedeva ◽  
...  
Keyword(s):  
Liver Cirrhosis ◽  
Hepatitis C ◽  
Viral Hepatitis ◽  
Chronic Viral Hepatitis ◽  
Viral Hepatitis C ◽  
High Incidence ◽  
Chronic Viral Hepatitis C

The problem of chronic viral hepatitis C currently remains relevant due to the high incidence, frequent outcomes in liver cirrhosis, high disability of the population, and expensive treatment. The article discusses timely approaches to the treatment of chronic viral hepatitis C, using interferon-free therapy regimens.

Antiviral therapy of liver cirrhosis in the outcome of chronic viral hepatitis C

2021 ◽  
pp. 89-97
Author(s):  
ANARKAN SHABOLOTOVNA TASHPOLOTOVA ◽  
GULMIRA SAIBILDAEVNA SURANBAEVA ◽  
MYSKAL MAMAZIAEVNA ABDIKERIMOVA ◽  
ALTYNAI BORUBAEVNA MYRZAKULOVA ◽  
ANARA SHAMSHIDINOVNA DJUMAGULOVA ◽  
...  
Keyword(s):  
Liver Cirrhosis ◽  
Hepatitis C ◽  
Viral Hepatitis ◽  
Antiviral Therapy ◽  
Chronic Viral Hepatitis ◽  
Viral Hepatitis C ◽  
Chronic Viral Hepatitis C
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