HUBUNGAN PEMAKAIAN KONTRASEPSI HORMONAL TERHADAP KUANTITAS TEAR FILM

EDISI PIT X KG 2018 - Medika Kartika Jurnal Kedokteran dan Kesehatan ◽

10.35990/mk.v4n5.p483-492 ◽

2021 ◽

pp. 483-492

Author(s):

Muhammad Syauqie ◽

Najdah Fakhirah Karami

Keyword(s):

Dry Eye ◽

Ocular Surface ◽

Tear Film ◽

Disease Index ◽

Ocular Surface Disease ◽

Ocular Surface Disease Index ◽

Tear Meniscus

Mata kering adalah penyakit multifaktorial yang ditandai dengan hilangnya homeostasis tear film yang diikuti gejala okular akibat penurunan kuantitas tear film. Pada jaringan mata, hormon seksual berperan dalam mengatur struktur dan fungsi dari kelenjar lakrimal. Penggunaan kontrasepsi hormonal merupakan salah satu terapi sistemik yang dapat dihubungkan dengan penurunan kuantitas tear film. Penelitian ini merupakan penelitian analitik dengan pendekatan observasional pada 40 orang wanita dengan rentang usia 21-44 tahun. Kelompok sampel adalah wanita yang menggunakan kontrasepsi hormonal minimal dalam 1 tahun dan kelompok kontrol adalah kelompok yang tidak menggunakan kontrasepsi hormonal. Hasil penelitian dan analisis data mendapatkan rerata uji Schirmer kelompok sampel dan kontrol adalah (21,3±12,7) dan (23,9±10). Rerata terkecil uji Schirmer adalah pada kontrasepsi jenis injeksi 3 bulan, yaitu (18,2 ± 11,6). Pada tear meniscus terjadi penurunan pada kelompok sampel (40%) dan kontrol (30%). Hasil kuesioner ocular surface disease index (OSDI) kelompok sampel didapatkan dry eye ringan (20%), sedang (20%), dan berat (5%). Sementara itu kelompok kontrol hanya mengalami dry eye ringan (45%). Dalam penelitian ini menunjukkan tidak terdapat perbedaan hasil yang bermakna (p > 0,05) antara kelompok tersebut. Kesimpulan yang didapatkan adalah tidak terdapat hubungan yang bermakna pemakaian kontrasepsi hormonal dengan kuantitas tear film.

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Correlation between ocular-surface disease index questionnaire, tear film break-up time and schirmer tests for evaluation of the tear film in patients of dry eye syndrome

International Journal of Medical Research and Review ◽

10.17511/ijmrr.2016.i03.04 ◽

2016 ◽

Vol 4 (3) ◽

pp. 309-313

Author(s):

Dr Sapna Raghuwanshi ◽

◽

Dr Rahul Agarwal ◽

Dr Shivkumar Raghuwanshi ◽

Dr Pallavi R Shidhaye ◽

...

Keyword(s):

Dry Eye ◽

Ocular Surface ◽

Tear Film ◽

Disease Index ◽

Dry Eye Syndrome ◽

Ocular Surface Disease ◽

Ocular Surface Disease Index ◽

Break Up

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Topical Cyclosporine in Treatment of Post-LASIK Symptomatic Dry Eye

Pakistan Journal of Ophthalmology ◽

10.36351/pjo.v36i4.1078 ◽

2020 ◽

Vol 36 (4) ◽

Author(s):

Muhammad Saeed Iqbal ◽

Kanwal Latif

Keyword(s):

Dry Eye ◽

Cyclosporine A ◽

Ocular Surface ◽

Case Series ◽

Tear Film ◽

Disease Index ◽

Ocular Surface Disease ◽

P Value ◽

Statistical Interpretation ◽

Ocular Surface Disease Index

Purpose: To determine the role of 0.05% topical cyclosporine A (CsA) in treatment of symptomatic dry eye after LASIK (Laser-Assisted in Situ Keratomileusis). Study Design: Interventional Case Series. Place and Duration of Study: Ophthalmology Department, Sir Syed Hospital, Karachi, from July 2018 to Dec. 2019. Methods: Seventy-five patients who underwent LASIK for myopic refractive error and presented with symptomatic dry eye and showed no response to artificial tears therapy after 1 month of LASIK were selected. The patient had ablation zone diameter of 6mm and flap diameter was 8.5mm to 9mm. Cyclisporine A 0.05% ophthalmic preparation was added to treatment regimen and response was observed at 1, 3 and 6 months. OSDI (Ocular Surface Disease Index) scores, Tear film break up time (TBUT), Schirmer's test (ST) values and Best Corrected Visual Acuity (BCVA) were recorded to analyze the treatment response at each visit. The statistical interpretation was done by using SPSS version 21. To interpret the correlation between pre-treatment and 6 month post treatment, Paired sample T test was applied with 95% Confidence Interval; CI and p-value of ≤ 0.05. Results: The mean post-LASIK OSDI score of enrolled patients was 54.25 ± 10.81. After 6 months of treatment mean OSDI score was improved to 21.05 ± 5.13 (p < 0.001). Post-LASIK mean ST value was 5.2 ± 1.2 mm and mean TBUT value was 5.6 ± 1.3 seconds, which changed to 9.8 ± 1.0 mm and 8.9 ± 1.1 seconds respectively. BCVA improved from Log MAR 0.14 ± 0.09 to 0.01 ± 0.03 (p < 0.001). Conclusion: Topical CsA 0.05% was effective in alleviating the symptoms of post-LASIK dry eye. Key Words: LASIK, Dry eye, Ocular Surface Disease Index Score, Cyclosporine A.

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Comparison of Clinical Use of Ocular-surface Disease Index Questionnaire, Tear Film Break-up time, and Schirmer Tests in Diagnosing Dry-eye

Ophthalmology Research An International Journal ◽

10.9734/or/2019/v11i230125 ◽

2019 ◽

pp. 1-7

Author(s):

Suwarna Suman ◽

Prachi Goyal

Keyword(s):

Dry Eye ◽

Ocular Surface ◽

Tear Film ◽

Dry Eye Disease ◽

Disease Index ◽

Ocular Surface Disease ◽

Eye Disease ◽

Ocular Surface Disease Index ◽

Schirmer’S Test ◽

The Mean

Aims: To evaluate and compare the diagnostic values and clinical utility of the Ocular Surface Disease Index (OSDI) questionnaire, the tear film break-up time test (TBUT), and the Schirmer’s test in diagnosing dry eye disease in patients presenting with dry eye symptoms. Study Design: A prospective observational study. Place and Duration of Study: Department of Ophthalmology, AIIMS Jodhpur, Rajasthan, India. Two-month period between July 2016 and September 2016. Methodology: We have included 100 patients aged >20 years having foreign body sensations, burning sensations, pain, dryness, blurred vision, photophobia, redness in the study. Routine ophthalmological examination was performed after OSDI questionnaire, followed by TBUT and Schirmer’s test and outcomes were evaluated. Results: The mean age of 100 participants was 43 ± 15.97years (range 20–78 years). The mean OSDI, TBUT, and Schirmer’s test scores were 58.67± 12.12 (range 30.0–88.9), 5.77 ± 3.49 seconds (range 0–17 seconds), and 09.78 ± 7.93 mm (range 0–32.5 mm), respectively. There was a statistically highly significant inverse correlation between the OSDI and TBUT (r = −0.597, P = <0.0001), statistically significant correlation between TBUT and Schirmer test (r= -0.227, p= 0.023), whereas no significant correlation noted between the OSDI and Schirmer’s test (r= -0.142, p= 0.158). Conclusion: The prevalence of dry eye disease (DED) is increasing these days. For early recognition and treatment, we need rapid, reliable and less invasive diagnostic test in daily practice. The OSDI together with the TBUT is less time consuming, easy to perform and can be useful in diagnosis of DED.

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