Evaluation of the Antioxidant Effectiveness in Reduction of the Dry Eye Syndrome among Patients with Relevant Toxicoallergic Component and a Severe Case of Corneal-Conjunctival Xerosis

Currently the ophthalmologists meet with corneal-conjunctival xerosis more often in their daily practice. The objective of this research is identifying a new alternative method of treatment of the dry eye syndrome of different severity. In this work there will be a demonstration and the results of usage of BAA Delphanto® in treatment of different cases of the dry eye syndrome. The data collected from a dynamic research of groups of patients reveals the effectiveness of the comprehensive therapy with the use of BAA Delphanto®. Consequently, the research results demonstrate an improvement of the initial data from the biomicroscopy, OSDI index, Schirmer-1 test and the tear break up time. The statistically significant results were received reveal the effectiveness of the use of BAA Delphanto® with a significant improvement of the quality of life. It can be used widely by ophthalmologists for the treatment of corneal-conjunctival xerosis of different severity.

Peculiarities of the Anterior Surface of the Eye in Patients with Newly Diagnosed Primary Open-Angle Glaucoma

The aim. To conduct an analysis of the anterior surface of the eye in patients with the newly diagnosed primary open-angle glaucoma in order to choose treatment with or without preservative. Materials and methods. We evaluated the front surface of the eye in 46 patients (92 eyes) diagnosed with primary open-angle glaucoma: 20 men and 26 women aged from 58 to 80 years. The anterior surface of the eye was examined using an analyzer of the anterior eye. Results. The signs of previously diagnosed dry eye syndrome (DES) with various manifestations of dysfunction of meibomian glands and complaints about dry eyes, foreign body sensation, lacrimation and blurred vision were reported in 39 patients (85%). Based on the examination results, preservative-free topical hypotensive medications were recommended for these 39 patients. Conclusion. In order to preserve visual functions and quality of life in patients with newly diagnosed POAG, it is advisable to conduct a preliminary assessment of the condition of the anterior surface of the eye when prescribing drug therapy in order to rationalize the choice of first-line drugs with or without preservative in accordance with the European recommendations of Diagnosis and Treatment for glaucoma. Keywords: preservative-free medications, dry eye syndrome, primary open-angle glaucoma.

Clinical Analysis of Dry Eye Syndrome According to Anterior Displacement of the Marx Line

Purpose: To evaluate the clinical characteristics of patients with dry eye syndrome according to anterior displacement of the Marx line.Methods: This retrospective study involved 127 eyes in 127 patients with dry eye, who were divided into three groups: group 1, aqueous-deficient, including Sjögren syndrome; group 2, meibomian gland dysfunction (MGD) dry eye; and group 3, other tear layer instability. A detailed assessment was conducted, involving the Ocular Surface Disease Index, corneal fluorescein staining (score: 0-15), conjunctival Lissamine green staining (score: 0-12), measurement of tear breakup time, and Schirmer’s test.Results: The proportion of patients with MGD was highest in the group with anterior displacement of the Marx line (p < 0.05). The correlation between anterior dislocation of the Marx line and Schirmer’s test, an objective indicator of dry eye syndrome, was significantly weaker when there was anterior displacement of the Marx line.Conclusions: Anterior dislocation of the Marx line was more common in patients with MGD. The Marx line is a useful marker for diagnosing MGD.

Understanding of Dry Eye Syndrome in Traditional Chinese Medicine

Explore the current status of Chinese medicine understanding and prevention and treatment of dry eye, so as to improve the efficacy of Chinese medicine in the diagnosis and treatment of dry eye.

Ayurvedic Management of Severe Dry Eye Syndrome & Complications: A Case Study

Dry eye syndrome (DES) is a common condition that causes pain and can lead to vision problems. Modern living has given rise to a massive increase in the incidence of vision threatening dry eye disease, around 10-30% of population living in industrialized countries suffer from dry eye syndrome (DES). According to Second International Dry Eye Workshop (DEWS II) in 2017 offered dry eye as it is a multifactorial ocular surface disorder defined by a loss of tear film homeostasis and ocular symptoms, in which tear film instability and hyperosmolarity, as well as ocular surface inflammation and injury, play a part in the etiology. If it is not controlled with in time it can lead to corneal blindness. Ayurveda proposes a comprehensive systemic & topical strategy in the treatment of dry eye syndrome, in contrast to the available modern medical treatment. In this publication, a case study of a Shushkakshipaka with many complications who was treated with dynamic Ayurvedic treatments & after continuous efforts patient got very significant results is being discussed here.

Efficacy of Haridradwayadi Rasakriyanjana in Shushkakshipaka w.s.r to Dry Eye Syndrome- A Case Report

Tear secretion is an integral component of the ocular surface physiology; when compromised (quantitatively or qualitatively) lead to Dry eye syndrome with several ocular symptoms and ultimately the patient may end up in corneal blindness. The symptoms of Dry eye syndrome are similar to the disease Shushkakshipaka (ocular surface inflammatory syndrome) in Ayurveda. Vata & Pitta vitiation as per Ayurveda viewpoint are the major contributing pathological factors in its manifestation. Although a number of researches have been carried out and are still continuing, no curative treatment has been achieved yet. This paper aims to establish the efficacy of Haridradwayadi Rasakriyanjana during the clinical observation of a 55 years old female subject who was diagnosed with Shushkakshipaka. She was administered with the drug Haridradwayadi Ghrita in the form of Rasakriyanjana (semi-solid collyrium) drops topically for 30 days, by using subjective and objective assessment criteria which showed a significant result. After the treatment, majority of the symptoms reduced considerably and during the follow up concluded that there was no aggravation of the same.

Dry eye syndrome in patients with gout

Purpose. To determine and study the features of the development of dry eye syndrome (DES) in gout, depending on urate-lowering therapy, the duration of the gout disease and the concentration of uric acid in the tear. Material and methods. The study involved 149 male patients (261 eyes) aged 35 to 75 years (mean age 60.63 ± 11.00 years). Among them, 110 people (202 eyes) with an established diagnosis: "Cataract with concomitant gout disease" and 39 people (59 eyes) with cataracts without clinical and laboratory signs of gout. All patients underwent both standard ophthalmological examinations and special ones. The concentration of uric acid in tears was determined by high performance liquid chromatography (HPLC). The diagnosis of gout was confirmed according to the criteria recommended by ACR / EULAR (2016). Results. In patients with gout who do not take a urate-lowering drug, DES occurs more often (82.1%) than in patients without gout (23.1%). With an increase in the concentration of uric acid in the tear, there is a high tendency to a shortening of the tear film rupture time (strong correlation coefficient r=-0.51, p<0.001) and to a decrease in tear production (Schirmer I test) (strong correlation coefficient r=-0.59, p<0.001). Conclusion. The data obtained indicate clear changes in the functional parameters of total tear production (Schirmer I's test) and the stability of the pre-corneal tear film (Norn's test) in patients with gout. This can be considered as a fact of the predisposition of this category of patients to the development of DES. A strong dependence of changes in tear production and HRVP on the concentration of uric acid in the tear was established. There is an obvious need for additional examination of this category of patients and an adequate choice of therapy, as well as the timely appointment of "artificial tear" drugs. Key words: dry eye syndrome, uric acid, gout.

Frequency of Dry Eye in Glaucoma Patients Using Topical Anti-Glaucoma Therapy

Aim: To determine the prevalence of dry eye in glaucoma patients using topical anti-glaucoma therapy. Study Design: Descriptive observational study Place and duration of study: Department of Ophthalmology, Shalimar Medical & Dental College Lahore from 1st November 2020 to 30th April 2021. Methodology: Ninety patients of both genders were enrolled. Detailed demographics of enrolled cases age, sex and body mass index were recorded after taking informed written consent. Patients using topical anti-glaucoma therapy for more than 8 months and having symptoms of stinging and burning sensations itching, watering, irritation, due to regular use of topical antiglaucoma drugs were presented. Basal Schrimer’s test and tear film break-up time test was used to measure the frequency of dry eye syndrome as mild, moderate and severe. Results: There were 60 (66.7%) females and 30 (33.3%) patients were males. Mean age of the patients were 45.61±7.66 years with mean BMI 26.24±8.71 kg/m2. We found that 40 (44.4%) patients had burning and stinging sensations, itching found in 21 (23.3%), dry eye sensations were found in 16 (17.8%) patients and watering and irritation found in 13 (14.4%) .According to tear film break-up time test 20 (22.2%) cases did not show dry eye syndrome and 19 (21.1%) patients were normal in Basal Schrimer’s test. Conclusion: Use of topical anti-glaucoma medication resulted in dry eye syndrome as well as a decrease in the tear film's stability. Keywords: Anti-glaucoma therapy, Basal Schrimer`s test, Tear film break-up time, Anti-glaucoma therapy, Dry eye syndrome