GIANT PRIMARY AMYLOIDOSIS OF URINARY BLADDER MANAGED BY SEGMENTAL CYSTECTOMY: A RARE CASE REPORT WITH REVIEW OF LITERATURE.
Amyloidosis is a heterogeneous group of disorders with amyloid material deposit in the extracellular compartment of the body as fibrillary protein which may be generalized or localized. Primary amyloidosis of urinary bladder is rare and large lesion measuring more than 8x8cm2 in size is not known. Majority, clinically presents with painless haematuria and irritative voiding symptoms which may confused with diagnosis of bladder carcinoma. Definitive diagnosis is made on histopathogical examination of tissue removed through cystoscopy or biopsy and after special staining. It diagnosis should alert physician to arrange for referral or appropriate investigations. Medical ttreatment using colchicine or dimethyl sulphoxide (DMSO) has been reported in the literature with good results. However, the majority of cases are still managed by transurethral resections of lesion. To our knowledge, this is first case of giant amyloidosis of urinary bladder managed by segmental cystectomy.