scholarly journals A Quantitative Model of Human Jejunal Smooth Muscle Cell Electrophysiology

Physiome ◽  
2021 ◽  
Author(s):  
Weiwei Ai ◽  
David Nickerson
Keyword(s):  
Smooth Muscle ◽  
Action Potential ◽  
Computational Model ◽  
Smooth Muscle Cell ◽  
Muscle Cell ◽  
Ionic Currents ◽  
Quantitative Model ◽  
Whole Cell

The Poh et al. (2012) paper describes the first biophysically based computational model of human jejunal smooth muscle cell (hJSMC) electrophysiology. The ionic currents are described by either a traditional Hodgkin-Huxley (HH) formalism or a deterministic multi-state Markov (MM) formalism. We create a modularized CellML implementation of the model, which is able to reproduce clamping behaviours of individual currents and whole cell action potential traces. In addition, some inconsistencies have been uncovered and discussed in this paper.

scholarly journals A Quantitative Model of Human Jejunal Smooth Muscle Cell Electrophysiology

Physiome ◽  
2021 ◽  
Author(s):  
Weiwei Ai ◽  
David Nickerson
Keyword(s):  
Smooth Muscle ◽  
Action Potential ◽  
Computational Model ◽  
Smooth Muscle Cell ◽  
Muscle Cell ◽  
Ionic Currents ◽  
Quantitative Model ◽  
Whole Cell

The Poh et al. (2012) paper describes the first biophysically based computational model of human jejunal smooth muscle cell (hJSMC) electrophysiology. The ionic currents are described by either a traditional Hodgkin-Huxley (HH) formalism or a deterministic multi-state Markov (MM) formalism. We create a modularized CellML implementation of the model, which is able to reproduce clamping behaviours of individual currents and whole cell action potential traces. In addition, some inconsistencies have been uncovered and discussed in this paper.

scholarly journals A Quantitative Model of Human Jejunal Smooth Muscle Cell Electrophysiology

Physiome ◽  
2021 ◽  
Author(s):  
Weiwei Ai ◽  
David Nickerson
Keyword(s):  
Smooth Muscle ◽  
Action Potential ◽  
Computational Model ◽  
Smooth Muscle Cell ◽  
Muscle Cell ◽  
Ionic Currents ◽  
Quantitative Model ◽  
Whole Cell

The Poh et al. (2012) paper describes the first biophysically based computational model of human jejunal smooth muscle cell (hJSMC) electrophysiology. The ionic currents are described by either a traditional Hodgkin-Huxley (HH) formalism or a deterministic multi-state Markov (MM) formalism. We create a modularized CellML implementation of the model, which is able to reproduce clamping behaviours of individual currents and whole cell action potential traces. In addition, some inconsistencies have been uncovered and discussed in this paper.

scholarly journals A Quantitative Model of Human Jejunal Smooth Muscle Cell Electrophysiology

Physiome ◽  
2021 ◽  
Author(s):  
Weiwei Ai ◽  
David Nickerson
Keyword(s):  
Smooth Muscle ◽  
Action Potential ◽  
Computational Model ◽  
Smooth Muscle Cell ◽  
Muscle Cell ◽  
Ionic Currents ◽  
Quantitative Model ◽  
Whole Cell

The Poh et al. (2012) paper describes the first biophysically based computational model of human jejunal smooth muscle cell (hJSMC) electrophysiology. The ionic currents are described by either a traditional Hodgkin-Huxley (HH) formalism or a deterministic multi-state Markov (MM) formalism. We create a modularized CellML implementation of the model, which is able to reproduce clamping behaviours of individual currents and whole cell action potential traces. In addition, some inconsistencies have been uncovered and discussed in this paper. EDITOR'S NOTE (v2): A typographical correction in the reproducibility report was made. (v3): This Abstract was appended with a note on changes made to versions.

scholarly journals A Chemomechanobiological Model of the Long-Term Healing Response of Arterial Tissue to a Clamping Injury

2021 ◽  
Vol 8 ◽  
Author(s):  
Lauranne Maes ◽  
Julie Vastmans ◽  
Stéphane Avril ◽  
Nele Famaey
Keyword(s):  
Extracellular Matrix ◽  
Smooth Muscle ◽  
Computational Model ◽  
Smooth Muscle Cell ◽  
Muscle Cell ◽  
Phenotypic Switching ◽  
Cell Phenotype ◽  
Arterial Tissue

Vascular clamping often causes injury to arterial tissue, leading to a cascade of cellular and extracellular events. A reliable in silico prediction of these processes following vascular injury could help us to increase our understanding thereof, and eventually optimize surgical techniques or drug delivery to minimize the amount of long-term damage. However, the complexity and interdependency of these events make translation into constitutive laws and their numerical implementation particularly challenging. We introduce a finite element simulation of arterial clamping taking into account acute endothelial denudation, damage to extracellular matrix, and smooth muscle cell loss. The model captures how this causes tissue inflammation and deviation from mechanical homeostasis, both triggering vascular remodeling. A number of cellular processes are modeled, aiming at restoring this homeostasis, i.e., smooth muscle cell phenotype switching, proliferation, migration, and the production of extracellular matrix. We calibrated these damage and remodeling laws by comparing our numerical results to in vivo experimental data of clamping and healing experiments. In these same experiments, the functional integrity of the tissue was assessed through myograph tests, which were also reproduced in the present study through a novel model for vasodilator and -constrictor dependent smooth muscle contraction. The simulation results show a good agreement with the in vivo experiments. The computational model was then also used to simulate healing beyond the duration of the experiments in order to exploit the benefits of computational model predictions. These results showed a significant sensitivity to model parameters related to smooth muscle cell phenotypes, highlighting the pressing need to further elucidate the biological processes of smooth muscle cell phenotypic switching in the future.

scholarly journals A Quantitative Model of Human Jejunal Smooth Muscle Cell Electrophysiology

PLoS ONE ◽  
2012 ◽  
Vol 7 (8) ◽  
pp. e42385 ◽  
Author(s):  
Yong Cheng Poh ◽  
Alberto Corrias ◽  
Nicholas Cheng ◽  
Martin Lindsay Buist
Keyword(s):  
Smooth Muscle ◽  
Smooth Muscle Cell ◽  
Muscle Cell ◽  
Quantitative Model

scholarly journals Ionic currents in single ureter smooth muscle cell

1988 ◽  
Vol 46 ◽  
pp. 163
Author(s):  
Katsuhiko Muraki ◽  
Yuji Imaizumi ◽  
Minoru Watanabe
Keyword(s):  
Smooth Muscle ◽  
Smooth Muscle Cell ◽  
Muscle Cell ◽  
Ionic Currents

scholarly journals A four-component model of the action potential in mouse detrusor smooth muscle cell

PLoS ONE ◽  
2018 ◽  
Vol 13 (1) ◽  
pp. e0190016 ◽  
Author(s):  
Mithun Padmakumar ◽  
Keith L. Brain ◽  
John S. Young ◽  
Rohit Manchanda
Keyword(s):  
Smooth Muscle ◽  
Action Potential ◽  
Smooth Muscle Cell ◽  
Muscle Cell ◽  
Component Model ◽  
Detrusor Smooth Muscle ◽  
Four Component Model
Sign in / Sign up

Export Citation Format

Share Document