FORMULATION AND EVALUATION OF GREWIATENAX FRUITS AS EFFERVESCENT TABLETS FOR TREATMENT OF IRON DEFICIENCY ANEMIA

Grewiatenax fruits as nutritional supplement are being widely used in traditional medicine in most parts of Sudan to treat anemic patients. This study was conducted to specify the most productive method for extractingG. tenax fruits and to standardize and formulate the extract into effervescent tablets. The fruits were extracted by hot and cold extraction with maceration using 80%, 65%, and 50% ethanol strength and the extracts were standardized. Two formulae (F1 and F2) were prepared from the extract and compressed into tablets. The formulated tablets were subjected for quality control tests. The 80% ethanol extract showed the highest extract yield and iron contents comparing to other extracts. The formulated tablets of both formulae showed good quality and pass all quality control tests.G. tenax fruitsextract could be pharmaceutically formulated into tablets which exhibited good quality control.To maximize yield value ofG. tenax fruitsextract, maceration method using 80% ethanol strength is of paramount importance.